Apolipoprotein E and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women
Summary Objective Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD). Design Cross‐sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity....
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2009-08, Vol.71 (2), p.284-290 |
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| creator | Lambrinoudaki, Irene Kaparos, George Rizos, Demetrios Galapi, Fotini Alexandrou, Andreas Sergentanis, Theodoros N. Creatsa, Maria Christodoulakos, George Kouskouni, E. Botsis, D. |
| description | Summary
Objective Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD).
Design Cross‐sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity.
Patients In total 84 healthy postmenopausal women aged 49–69 years.
Measurements FT3, FT4, anti‐TPO and anti‐TG were assessed in the sera of participants. The following polymorphisms were assessed from peripheral lymphocyte DNA: Apolipoprotein E E2/E3/E4, paraoxonase 1 A/B, Glycoprotein IIIa leu33pro, MTHFR ala222val, ApoBarg3500gln, plasminogen activator inhibitor 1 4G/5G, cholesterol 7‐α hydroxylase A204C and cholesterol ester transfer protein B1/B2.
Results A statistically significant correlation was found between Apolipoprotein E and paraoxonase1 polymorphisms and serum thyroid hormones: carriers of the E2 or E4 allele of the ApoE gene had lower levels of FT4 (P = 0·0005) than women with the E3/E3 genotype. Carriers of the B allele of paraoxonase 1 gene had lower levels of FT3 compared to women with the wild‐type genotype (P = 0·047). A statistically significant positive association (P = 0·049) was also observed between anti‐TG antibodies and the presence of the E2 allele of the Apolipoprotein E gene.
Conclusions Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone and anti‐Tg antibody levels in the study population in this pilot study. The mechanism underlying this association remains to be elucidated. |
| doi_str_mv | 10.1111/j.1365-2265.2008.03476.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67490278</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67490278</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4666-627f279c7ee4c6c7995d3c6cd6499d0e1fee03e5cee0afad393452caa24791743</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EokvhLyBf4Jbgj8SODxyqZWkrVaUgEL1ZxplovSRxsBPt5t_jsKvlCL7MWPO84xm_CGFKcprOu11OuSgzxkSZM0KqnPBCivzwBK3OhadoRTghGRGiuEAvYtwRQsqKyOfogipCKynVCs1Xg2_d4IfgR3A93mDT1_jBBOMPvjcRMMWJmDsfhq2LXcQmADYxeuvMCDXeu3GLW7-HgCOEqcPjdg7e1XjrQ-d7iDh1HXwcO-j9YKZoWrz36fISPWtMG-HVKV6ibx83X9c32d2n69v11V1mCyFEJphsmFRWAhRWWKlUWfOU1KJQqiZAGwDCobQpmMbUXPGiZNYYVkhFZcEv0dtj37TirwniqDsXLbSt6cFPUQtZKMJk9U-QEapKWi5gdQRt8DEGaPQQXGfCrCnRiz96pxcb9GKDXvzRf_zRhyR9fXpj-tFB_Vd4MiQBb06Aida0TTC9dfHMMZrGpZIn7v2R27sW5v8eQK8390uW9NlR7-IIh7PehJ_pQ7gs9ff7a_34RcnP1cOj_sB_A3fuvX4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20195158</pqid></control><display><type>article</type><title>Apolipoprotein E and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lambrinoudaki, Irene ; Kaparos, George ; Rizos, Demetrios ; Galapi, Fotini ; Alexandrou, Andreas ; Sergentanis, Theodoros N. ; Creatsa, Maria ; Christodoulakos, George ; Kouskouni, E. ; Botsis, D.</creator><creatorcontrib>Lambrinoudaki, Irene ; Kaparos, George ; Rizos, Demetrios ; Galapi, Fotini ; Alexandrou, Andreas ; Sergentanis, Theodoros N. ; Creatsa, Maria ; Christodoulakos, George ; Kouskouni, E. ; Botsis, D.</creatorcontrib><description>Summary
Objective Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD).
Design Cross‐sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity.
Patients In total 84 healthy postmenopausal women aged 49–69 years.
Measurements FT3, FT4, anti‐TPO and anti‐TG were assessed in the sera of participants. The following polymorphisms were assessed from peripheral lymphocyte DNA: Apolipoprotein E E2/E3/E4, paraoxonase 1 A/B, Glycoprotein IIIa leu33pro, MTHFR ala222val, ApoBarg3500gln, plasminogen activator inhibitor 1 4G/5G, cholesterol 7‐α hydroxylase A204C and cholesterol ester transfer protein B1/B2.
Results A statistically significant correlation was found between Apolipoprotein E and paraoxonase1 polymorphisms and serum thyroid hormones: carriers of the E2 or E4 allele of the ApoE gene had lower levels of FT4 (P = 0·0005) than women with the E3/E3 genotype. Carriers of the B allele of paraoxonase 1 gene had lower levels of FT3 compared to women with the wild‐type genotype (P = 0·047). A statistically significant positive association (P = 0·049) was also observed between anti‐TG antibodies and the presence of the E2 allele of the Apolipoprotein E gene.
Conclusions Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone and anti‐Tg antibody levels in the study population in this pilot study. The mechanism underlying this association remains to be elucidated.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2008.03476.x</identifier><identifier>PMID: 19018779</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Apolipoproteins E - genetics ; Aryldialkylphosphatase - genetics ; Biological and medical sciences ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - genetics ; Cross-Sectional Studies ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Humans ; Medical sciences ; Middle Aged ; Polymorphism, Genetic ; Postmenopause - blood ; Postmenopause - genetics ; Thyroid Hormones - blood ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2009-08, Vol.71 (2), p.284-290</ispartof><rights>2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4666-627f279c7ee4c6c7995d3c6cd6499d0e1fee03e5cee0afad393452caa24791743</citedby><cites>FETCH-LOGICAL-c4666-627f279c7ee4c6c7995d3c6cd6499d0e1fee03e5cee0afad393452caa24791743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2008.03476.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2008.03476.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21674173$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19018779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lambrinoudaki, Irene</creatorcontrib><creatorcontrib>Kaparos, George</creatorcontrib><creatorcontrib>Rizos, Demetrios</creatorcontrib><creatorcontrib>Galapi, Fotini</creatorcontrib><creatorcontrib>Alexandrou, Andreas</creatorcontrib><creatorcontrib>Sergentanis, Theodoros N.</creatorcontrib><creatorcontrib>Creatsa, Maria</creatorcontrib><creatorcontrib>Christodoulakos, George</creatorcontrib><creatorcontrib>Kouskouni, E.</creatorcontrib><creatorcontrib>Botsis, D.</creatorcontrib><title>Apolipoprotein E and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD).
Design Cross‐sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity.
Patients In total 84 healthy postmenopausal women aged 49–69 years.
Measurements FT3, FT4, anti‐TPO and anti‐TG were assessed in the sera of participants. The following polymorphisms were assessed from peripheral lymphocyte DNA: Apolipoprotein E E2/E3/E4, paraoxonase 1 A/B, Glycoprotein IIIa leu33pro, MTHFR ala222val, ApoBarg3500gln, plasminogen activator inhibitor 1 4G/5G, cholesterol 7‐α hydroxylase A204C and cholesterol ester transfer protein B1/B2.
Results A statistically significant correlation was found between Apolipoprotein E and paraoxonase1 polymorphisms and serum thyroid hormones: carriers of the E2 or E4 allele of the ApoE gene had lower levels of FT4 (P = 0·0005) than women with the E3/E3 genotype. Carriers of the B allele of paraoxonase 1 gene had lower levels of FT3 compared to women with the wild‐type genotype (P = 0·047). A statistically significant positive association (P = 0·049) was also observed between anti‐TG antibodies and the presence of the E2 allele of the Apolipoprotein E gene.
Conclusions Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone and anti‐Tg antibody levels in the study population in this pilot study. The mechanism underlying this association remains to be elucidated.</description><subject>Aged</subject><subject>Apolipoproteins E - genetics</subject><subject>Aryldialkylphosphatase - genetics</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Postmenopause - blood</subject><subject>Postmenopause - genetics</subject><subject>Thyroid Hormones - blood</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhLyBf4Jbgj8SODxyqZWkrVaUgEL1ZxplovSRxsBPt5t_jsKvlCL7MWPO84xm_CGFKcprOu11OuSgzxkSZM0KqnPBCivzwBK3OhadoRTghGRGiuEAvYtwRQsqKyOfogipCKynVCs1Xg2_d4IfgR3A93mDT1_jBBOMPvjcRMMWJmDsfhq2LXcQmADYxeuvMCDXeu3GLW7-HgCOEqcPjdg7e1XjrQ-d7iDh1HXwcO-j9YKZoWrz36fISPWtMG-HVKV6ibx83X9c32d2n69v11V1mCyFEJphsmFRWAhRWWKlUWfOU1KJQqiZAGwDCobQpmMbUXPGiZNYYVkhFZcEv0dtj37TirwniqDsXLbSt6cFPUQtZKMJk9U-QEapKWi5gdQRt8DEGaPQQXGfCrCnRiz96pxcb9GKDXvzRf_zRhyR9fXpj-tFB_Vd4MiQBb06Aida0TTC9dfHMMZrGpZIn7v2R27sW5v8eQK8390uW9NlR7-IIh7PehJ_pQ7gs9ff7a_34RcnP1cOj_sB_A3fuvX4</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Lambrinoudaki, Irene</creator><creator>Kaparos, George</creator><creator>Rizos, Demetrios</creator><creator>Galapi, Fotini</creator><creator>Alexandrou, Andreas</creator><creator>Sergentanis, Theodoros N.</creator><creator>Creatsa, Maria</creator><creator>Christodoulakos, George</creator><creator>Kouskouni, E.</creator><creator>Botsis, D.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200908</creationdate><title>Apolipoprotein E and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women</title><author>Lambrinoudaki, Irene ; Kaparos, George ; Rizos, Demetrios ; Galapi, Fotini ; Alexandrou, Andreas ; Sergentanis, Theodoros N. ; Creatsa, Maria ; Christodoulakos, George ; Kouskouni, E. ; Botsis, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4666-627f279c7ee4c6c7995d3c6cd6499d0e1fee03e5cee0afad393452caa24791743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Apolipoproteins E - genetics</topic><topic>Aryldialkylphosphatase - genetics</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Postmenopause - blood</topic><topic>Postmenopause - genetics</topic><topic>Thyroid Hormones - blood</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lambrinoudaki, Irene</creatorcontrib><creatorcontrib>Kaparos, George</creatorcontrib><creatorcontrib>Rizos, Demetrios</creatorcontrib><creatorcontrib>Galapi, Fotini</creatorcontrib><creatorcontrib>Alexandrou, Andreas</creatorcontrib><creatorcontrib>Sergentanis, Theodoros N.</creatorcontrib><creatorcontrib>Creatsa, Maria</creatorcontrib><creatorcontrib>Christodoulakos, George</creatorcontrib><creatorcontrib>Kouskouni, E.</creatorcontrib><creatorcontrib>Botsis, D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lambrinoudaki, Irene</au><au>Kaparos, George</au><au>Rizos, Demetrios</au><au>Galapi, Fotini</au><au>Alexandrou, Andreas</au><au>Sergentanis, Theodoros N.</au><au>Creatsa, Maria</au><au>Christodoulakos, George</au><au>Kouskouni, E.</au><au>Botsis, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein E and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2009-08</date><risdate>2009</risdate><volume>71</volume><issue>2</issue><spage>284</spage><epage>290</epage><pages>284-290</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD).
Design Cross‐sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity.
Patients In total 84 healthy postmenopausal women aged 49–69 years.
Measurements FT3, FT4, anti‐TPO and anti‐TG were assessed in the sera of participants. The following polymorphisms were assessed from peripheral lymphocyte DNA: Apolipoprotein E E2/E3/E4, paraoxonase 1 A/B, Glycoprotein IIIa leu33pro, MTHFR ala222val, ApoBarg3500gln, plasminogen activator inhibitor 1 4G/5G, cholesterol 7‐α hydroxylase A204C and cholesterol ester transfer protein B1/B2.
Results A statistically significant correlation was found between Apolipoprotein E and paraoxonase1 polymorphisms and serum thyroid hormones: carriers of the E2 or E4 allele of the ApoE gene had lower levels of FT4 (P = 0·0005) than women with the E3/E3 genotype. Carriers of the B allele of paraoxonase 1 gene had lower levels of FT3 compared to women with the wild‐type genotype (P = 0·047). A statistically significant positive association (P = 0·049) was also observed between anti‐TG antibodies and the presence of the E2 allele of the Apolipoprotein E gene.
Conclusions Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone and anti‐Tg antibody levels in the study population in this pilot study. The mechanism underlying this association remains to be elucidated.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19018779</pmid><doi>10.1111/j.1365-2265.2008.03476.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Apolipoproteins E - genetics Aryldialkylphosphatase - genetics Biological and medical sciences Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Cross-Sectional Studies Endocrinopathies Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Humans Medical sciences Middle Aged Polymorphism, Genetic Postmenopause - blood Postmenopause - genetics Thyroid Hormones - blood Vertebrates: endocrinology |
| title | Apolipoprotein E and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women |
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