Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

Budding yeast Slx4 interacts with the structure-specific endonuclease Slx1 to ensure completion of ribosomal DNA replication. Slx4 also interacts with the Rad1-Rad10 endonuclease to control cleavage of 3′ flaps during repair of double-strand breaks (DSBs). Here we describe the identification of huma...

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Veröffentlicht in:	Molecular cell 2009-07, Vol.35 (1), p.116-127
Hauptverfasser:	Muñoz, Ivan M., Hain, Karolina, Déclais, Anne-Cécile, Gardiner, Mary, Toh, Geraldine W., Sanchez-Pulido, Luis, Heuckmann, Johannes M., Toth, Rachel, Macartney, Thomas, Eppink, Berina, Kanaar, Roland, Ponting, Chris P., Lilley, David M.J., Rouse, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Line Cell Line, Tumor DNA DNA Breaks, Double-Stranded DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endonucleases - genetics Endonucleases - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Immunoprecipitation Protein Binding Recombinases - genetics Recombinases - metabolism RNA, Small Interfering - genetics Transfection Two-Hybrid System Techniques
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