Functional imaging of a large demyelinating lesion
To determine the metabolic characterization of a large solitary demyelinating lesion. Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro- d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the...
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| Veröffentlicht in: | Journal of clinical neuroscience 2005-02, Vol.12 (2), p.176-178 |
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| container_end_page | 178 |
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| container_title | Journal of clinical neuroscience |
| container_volume | 12 |
| creator | Padma, M.V. Adineh, M. Pugar, K. Mukherjee, J. Satter, M. Shi, B. Dunigan, K. Bidwell, K. Ezzeddine, B. Mantil, J. |
| description | To determine the metabolic characterization of a large solitary demyelinating lesion.
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-
d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion.
The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased
N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study.
The report summarizes the metabolic characteristics of a demyelinating plaque. |
| doi_str_mv | 10.1016/j.jocn.2004.02.024 |
| format | Article |
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Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-
d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion.
The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased
N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study.
The report summarizes the metabolic characteristics of a demyelinating plaque.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/j.jocn.2004.02.024</identifier><identifier>PMID: 15749424</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adult ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - pathology ; Brain Neoplasms - pathology ; choline ; Demyelinating Diseases - diagnostic imaging ; Demyelinating Diseases - pathology ; Diagnosis, Differential ; Female ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Spectroscopy ; Methionine ; MRI ; MRS ; multiple sclerosis ; Multiple Sclerosis - diagnostic imaging ; Multiple Sclerosis - metabolism ; Multiple Sclerosis - pathology ; PET ; Positron-Emission Tomography ; Radiography</subject><ispartof>Journal of clinical neuroscience, 2005-02, Vol.12 (2), p.176-178</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-af586e232d871b5b5a734d4130ddc6ebc9bb79f3e282b7eeaf526391656f98d93</citedby><cites>FETCH-LOGICAL-c354t-af586e232d871b5b5a734d4130ddc6ebc9bb79f3e282b7eeaf526391656f98d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0967586804002905$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15749424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Padma, M.V.</creatorcontrib><creatorcontrib>Adineh, M.</creatorcontrib><creatorcontrib>Pugar, K.</creatorcontrib><creatorcontrib>Mukherjee, J.</creatorcontrib><creatorcontrib>Satter, M.</creatorcontrib><creatorcontrib>Shi, B.</creatorcontrib><creatorcontrib>Dunigan, K.</creatorcontrib><creatorcontrib>Bidwell, K.</creatorcontrib><creatorcontrib>Ezzeddine, B.</creatorcontrib><creatorcontrib>Mantil, J.</creatorcontrib><title>Functional imaging of a large demyelinating lesion</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>To determine the metabolic characterization of a large solitary demyelinating lesion.
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-
d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion.
The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased
N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study.
The report summarizes the metabolic characteristics of a demyelinating plaque.</description><subject>Adult</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms - pathology</subject><subject>choline</subject><subject>Demyelinating Diseases - diagnostic imaging</subject><subject>Demyelinating Diseases - pathology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Methionine</subject><subject>MRI</subject><subject>MRS</subject><subject>multiple sclerosis</subject><subject>Multiple Sclerosis - diagnostic imaging</subject><subject>Multiple Sclerosis - metabolism</subject><subject>Multiple Sclerosis - pathology</subject><subject>PET</subject><subject>Positron-Emission Tomography</subject><subject>Radiography</subject><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRbK3-AReSlbvEeScBN1KsCgU3uh4mMzdlQh51JhH6753Ygjvhwl3c75zLOQjdEpwRTORDkzWD6TOKMc8wjcPP0JIIRlMqBTtHS1zKPBWFLBboKoQGY1xyhi_Rgoicl5zyJaKbqTejG3rdJq7TO9fvkqFOdNJqv4PEQneA1vV6nA8thEheo4tatwFuTnuFPjfPH-vXdPv-8rZ-2qaGCT6muo6fgTJqi5xUohI6Z9xywrC1RkJlyqrKy5oBLWiVA0SeSlYSKWRdFrZkK3R_9N374WuCMKrOBQNtq3sYpqBkzouiiJpVTPELGj-E4KFWex-z-IMiWM1NqUbNTam5KYVpHB5Fdyf3qerA_klO1UTg8QhAzPjtwKtgHPQGrPNgRmUH95__D3K2eWU</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Padma, M.V.</creator><creator>Adineh, M.</creator><creator>Pugar, K.</creator><creator>Mukherjee, J.</creator><creator>Satter, M.</creator><creator>Shi, B.</creator><creator>Dunigan, K.</creator><creator>Bidwell, K.</creator><creator>Ezzeddine, B.</creator><creator>Mantil, J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Functional imaging of a large demyelinating lesion</title><author>Padma, M.V. ; Adineh, M. ; Pugar, K. ; Mukherjee, J. ; Satter, M. ; Shi, B. ; Dunigan, K. ; Bidwell, K. ; Ezzeddine, B. ; Mantil, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-af586e232d871b5b5a734d4130ddc6ebc9bb79f3e282b7eeaf526391656f98d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - pathology</topic><topic>choline</topic><topic>Demyelinating Diseases - diagnostic imaging</topic><topic>Demyelinating Diseases - pathology</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Methionine</topic><topic>MRI</topic><topic>MRS</topic><topic>multiple sclerosis</topic><topic>Multiple Sclerosis - diagnostic imaging</topic><topic>Multiple Sclerosis - metabolism</topic><topic>Multiple Sclerosis - pathology</topic><topic>PET</topic><topic>Positron-Emission Tomography</topic><topic>Radiography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Padma, M.V.</creatorcontrib><creatorcontrib>Adineh, M.</creatorcontrib><creatorcontrib>Pugar, K.</creatorcontrib><creatorcontrib>Mukherjee, J.</creatorcontrib><creatorcontrib>Satter, M.</creatorcontrib><creatorcontrib>Shi, B.</creatorcontrib><creatorcontrib>Dunigan, K.</creatorcontrib><creatorcontrib>Bidwell, K.</creatorcontrib><creatorcontrib>Ezzeddine, B.</creatorcontrib><creatorcontrib>Mantil, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Padma, M.V.</au><au>Adineh, M.</au><au>Pugar, K.</au><au>Mukherjee, J.</au><au>Satter, M.</au><au>Shi, B.</au><au>Dunigan, K.</au><au>Bidwell, K.</au><au>Ezzeddine, B.</au><au>Mantil, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional imaging of a large demyelinating lesion</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>12</volume><issue>2</issue><spage>176</spage><epage>178</epage><pages>176-178</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>To determine the metabolic characterization of a large solitary demyelinating lesion.
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-
d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion.
The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased
N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study.
The report summarizes the metabolic characteristics of a demyelinating plaque.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>15749424</pmid><doi>10.1016/j.jocn.2004.02.024</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of clinical neuroscience, 2005-02, Vol.12 (2), p.176-178 |
| issn | 0967-5868 1532-2653 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Brain - diagnostic imaging Brain - metabolism Brain - pathology Brain Neoplasms - pathology choline Demyelinating Diseases - diagnostic imaging Demyelinating Diseases - pathology Diagnosis, Differential Female Fluorodeoxyglucose F18 Humans Magnetic Resonance Spectroscopy Methionine MRI MRS multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - metabolism Multiple Sclerosis - pathology PET Positron-Emission Tomography Radiography |
| title | Functional imaging of a large demyelinating lesion |
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