Familial aggregation of parkinsonism in progressive supranuclear palsy

Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder characterized by aggregates of the microtubule-associated protein tau (MAPT). A nonsignificant trend for positive family history has been observed in two case-control studies and several pedigrees with familial clusteri...

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Veröffentlicht in:	Neurology 2009-07, Vol.73 (2), p.98-105
Hauptverfasser:	KAAT, L. Donker, BOON, A. J. W, AZMANI, A, KAMPHORST, W, BRETELER, M. M. B, ANAR, B, HEUTINK, P, VAN SWIETEN, J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Brain - metabolism Brain - pathology Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - genetics Family Female Genetic Predisposition to Disease Humans Intercellular Signaling Peptides and Proteins - genetics Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Medical sciences Neurology Odds Ratio Parkinsonian Disorders - genetics Pedigree Phenotype Protein-Serine-Threonine Kinases - genetics Sequence Analysis, DNA Supranuclear Palsy, Progressive - epidemiology Supranuclear Palsy, Progressive - genetics Supranuclear Palsy, Progressive - metabolism Supranuclear Palsy, Progressive - pathology tau Proteins - genetics Tauopathies - genetics Tauopathies - metabolism Tauopathies - pathology Tremor - genetics
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