Proteome Analysis of Maternal Serum Samples for Trisomy 21 Pregnancies Using ProteinChip Arrays and Bioinformatics
A surface-enhanced laser desorption/ionization time of flight (SELDI-TOF)-based ProteinChip System was used as a tool for rapid discovery and identification of protein patterns in serum that discriminate between trisomy 21 and unaffected pregnancies. We analyzed 24 serum samples from women carrying...
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| Veröffentlicht in: | The journal of histochemistry and cytochemistry 2005-03, Vol.53 (3), p.341-343 |
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| container_end_page | 343 |
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| container_issue | 3 |
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| container_title | The journal of histochemistry and cytochemistry |
| container_volume | 53 |
| creator | Busch, Anne Michel, Susanne Hoppe, Constance Driesch, Dominik Claussen, Uwe von Eggeling, Ferdinand |
| description | A surface-enhanced laser desorption/ionization time of flight (SELDI-TOF)-based ProteinChip System was used as a tool for rapid discovery and identification of protein patterns in serum that discriminate between trisomy 21 and unaffected pregnancies. We analyzed 24 serum samples from women carrying a trisomy 21 pregnancy and 32 with an unaffected pregnancy, ranging from 10.0 to 14.0 weeks of gestation. The resulting protein profiles were submitted to a clustering algorithm, a rule extraction, a rating, and a rule base construction step. For the generated combined rule base, the specificity and sensitivity for the prediction of a trisomy 21 pregnancy reach 97% and 91%, respectively. |
| doi_str_mv | 10.1369/jhc.4B6377.2005 |
| format | Article |
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| subjects | Computational Biology Down Syndrome - blood Down Syndrome - diagnosis Female Humans Predictive Value of Tests Pregnancy Pregnancy Trimester, First Protein Array Analysis Proteome - analysis Serum Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods |
| title | Proteome Analysis of Maternal Serum Samples for Trisomy 21 Pregnancies Using ProteinChip Arrays and Bioinformatics |
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