Regulatory T Cells Suppress CD8+ T Cell Responses Induced by Direct Priming and Cross-Priming and Moderate Immunodominance Disparities

Little is known regarding the participation of CD4+ CD25+ regulatory T cells (Treg) in TCD8+ responses. In this study, we show that Treg depletion via treatment with anti-CD25 mAb (PC61) significantly enhances TCD8+ responses to influenza A virus, vaccinia virus, and SV40-transformed cells induced b...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-03, Vol.174 (6), p.3344-3351
Hauptverfasser:	Haeryfar, S. M. Mansour, DiPaolo, Richard J, Tscharke, David C, Bennink, Jack R, Yewdell, Jonathan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, Polyomavirus Transforming - genetics Antigens, Viral - genetics CD4 Antigens - genetics CD4 Antigens - metabolism CD4-Positive T-Lymphocytes - immunology Cytotoxicity, Immunologic Female Immune Tolerance Immunodominant Epitopes - genetics Influenza A virus - genetics Influenza A virus - immunology Lymphocyte Depletion Mice Mice, Inbred C57BL Mice, Knockout Peptide Fragments - genetics Peptide Fragments - immunology T-Lymphocytes - immunology Vaccinia virus - genetics Vaccinia virus - immunology
Online-Zugang:	Volltext
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