Regulatory T Cells Suppress CD8+ T Cell Responses Induced by Direct Priming and Cross-Priming and Moderate Immunodominance Disparities
Little is known regarding the participation of CD4+ CD25+ regulatory T cells (Treg) in TCD8+ responses. In this study, we show that Treg depletion via treatment with anti-CD25 mAb (PC61) significantly enhances TCD8+ responses to influenza A virus, vaccinia virus, and SV40-transformed cells induced b...
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| Veröffentlicht in: | The Journal of immunology (1950) 2005-03, Vol.174 (6), p.3344-3351 |
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| container_title | The Journal of immunology (1950) |
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| creator | Haeryfar, S. M. Mansour DiPaolo, Richard J Tscharke, David C Bennink, Jack R Yewdell, Jonathan W |
| description | Little is known regarding the participation of CD4+ CD25+ regulatory T cells (Treg) in TCD8+ responses. In this study, we show that Treg depletion via treatment with anti-CD25 mAb (PC61) significantly enhances TCD8+ responses to influenza A virus, vaccinia virus, and SV40-transformed cells induced by either direct priming or cross-priming. PC61 did not enhance TCD8+ responses in CD4-deficient mice, providing the initial demonstration that PC61 acts on a subset of TCD4+, and not on other cells that express either CD25 or a fortuitously cross-reactive Ag. We further show that Treg selectively suppress responses to the most immunodominant TCD8+ determinants in the three systems examined. Therefore, Treg influence TCD8 immunodominance hierarchies by moderating disparities in responses to different determinants. |
| doi_str_mv | 10.4049/jimmunol.174.6.3344 |
| format | Article |
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PC61 did not enhance TCD8+ responses in CD4-deficient mice, providing the initial demonstration that PC61 acts on a subset of TCD4+, and not on other cells that express either CD25 or a fortuitously cross-reactive Ag. We further show that Treg selectively suppress responses to the most immunodominant TCD8+ determinants in the three systems examined. Therefore, Treg influence TCD8 immunodominance hierarchies by moderating disparities in responses to different determinants.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigens, Polyomavirus Transforming - genetics</subject><subject>Antigens, Viral - genetics</subject><subject>CD4 Antigens - genetics</subject><subject>CD4 Antigens - metabolism</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Cytotoxicity, Immunologic</subject><subject>Female</subject><subject>Immune Tolerance</subject><subject>Immunodominant Epitopes - genetics</subject><subject>Influenza A virus - genetics</subject><subject>Influenza A virus - immunology</subject><subject>Lymphocyte Depletion</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Peptide Fragments - genetics</subject><subject>Peptide Fragments - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Vaccinia virus - genetics</subject><subject>Vaccinia virus - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkFtP3DAQhS1EBVvgFyAhP8FDlcVOfEkeUYB2JaoiLs-WY88uQbnhSbTaP9DfXW93q_I00sw5R3M-Qs45mwsmiuv3um2nrm_mXIu5mmeZEAdkxqVkiVJMHZIZY2macK30MfmK-M4YUywVR-SYSy2KXKkZ-f0Eq6mxYx829IWW0DRIn6dhCIBIy9v8235LnwCHvkNAuuj85MDTakNv6wBupI-hbutuRW3naRl6xOTz5mfvIdgR6OLvv76PF9s5iG4cbKjHGvCUfFnaBuFsP0_I6_3dS_kjefj1fVHePCQuy9mYLL2DwlnJnKw4T8FpL8Fz5bLUaSdyXnkpwVlm8yzN-bKQEURaae2cLxSI7IRc7nKH0H9MgKNpa3Sxn-2gn9AoLXKV8TQKs53QbfsEWJohVrJhYzgzW_zmH34T8Rtltvij62IfP1Ut-P-ePe8ouNoJ3urV2zrSM9japolybtbr9aeoP1LGksk</recordid><startdate>20050315</startdate><enddate>20050315</enddate><creator>Haeryfar, S. 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M. Mansour</creatorcontrib><creatorcontrib>DiPaolo, Richard J</creatorcontrib><creatorcontrib>Tscharke, David C</creatorcontrib><creatorcontrib>Bennink, Jack R</creatorcontrib><creatorcontrib>Yewdell, Jonathan W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haeryfar, S. M. 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PC61 did not enhance TCD8+ responses in CD4-deficient mice, providing the initial demonstration that PC61 acts on a subset of TCD4+, and not on other cells that express either CD25 or a fortuitously cross-reactive Ag. We further show that Treg selectively suppress responses to the most immunodominant TCD8+ determinants in the three systems examined. Therefore, Treg influence TCD8 immunodominance hierarchies by moderating disparities in responses to different determinants.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>15749866</pmid><doi>10.4049/jimmunol.174.6.3344</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Animals Antigens, Polyomavirus Transforming - genetics Antigens, Viral - genetics CD4 Antigens - genetics CD4 Antigens - metabolism CD4-Positive T-Lymphocytes - immunology Cytotoxicity, Immunologic Female Immune Tolerance Immunodominant Epitopes - genetics Influenza A virus - genetics Influenza A virus - immunology Lymphocyte Depletion Mice Mice, Inbred C57BL Mice, Knockout Peptide Fragments - genetics Peptide Fragments - immunology T-Lymphocytes - immunology Vaccinia virus - genetics Vaccinia virus - immunology |
| title | Regulatory T Cells Suppress CD8+ T Cell Responses Induced by Direct Priming and Cross-Priming and Moderate Immunodominance Disparities |
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