Do Implanted Pacemaker Leads and ICD Leads Cause Metal-Related Artifact in Cardiac PET/CT?
Artifacts related to metallic implants are an established limitation of CT-based attenuation correction (CT-AC) in PET/CT. However, the impact of metallic components of pacemaker leads and implantable cardioverter defibrillator (ICD) leads on the accuracy of cardiac PET has not been evaluated. The g...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 2005-03, Vol.46 (3), p.436-443 |
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| description | Artifacts related to metallic implants are an established limitation of CT-based attenuation correction (CT-AC) in PET/CT. However, the impact of metallic components of pacemaker leads and implantable cardioverter defibrillator (ICD) leads on the accuracy of cardiac PET has not been evaluated. The goal of this study was to investigate the magnitude of artifacts related to pacing and defibrillation leads in both phantom and patient studies.
Images were acquired on a PET/CT scanner using CT-AC and were compared with those obtained on a dedicated PET scanner using transmission source-based attenuation correction. Phantoms consisting of pacemaker leads and ICD leads submerged in uniform background activity solution were imaged, and regions were analyzed to measure radionuclide concentrations at known lead locations relative to background. In addition, 15 cardiac 18F-FDG patients (having either pacing leads, defibrillation leads, or both) were imaged on both PET/CT and PET scanners. Images were visually and quantitatively assessed to determine whether artifact related to the implanted leads was present and, if so, its severity relative to surrounding myocardium.
In phantom studies, artifacts caused by pacing lead electrodes were barely noticeable, but artifacts arising from highly radioopaque ICD shock coil electrodes were clearly apparent. In the patient studies, no artifacts from pacing leads were identified. However, significant artifact was observed in 50% of the patient studies with ICD leads. In the affected areas, local myocardial uptake in PET/CT images using CT-AC was, on average, 30% higher than that in the corresponding PET images.
Although pacemaker leads do not appear to cause artifact in cardiac PET/CT images, ICD leads frequently do result in artifacts of sufficient magnitude to impact clinical image interpretation. Accordingly, software-based corrections in CT-AC algorithms appear necessary for accurate cardiac imaging with PET/CT. |
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Images were acquired on a PET/CT scanner using CT-AC and were compared with those obtained on a dedicated PET scanner using transmission source-based attenuation correction. Phantoms consisting of pacemaker leads and ICD leads submerged in uniform background activity solution were imaged, and regions were analyzed to measure radionuclide concentrations at known lead locations relative to background. In addition, 15 cardiac 18F-FDG patients (having either pacing leads, defibrillation leads, or both) were imaged on both PET/CT and PET scanners. Images were visually and quantitatively assessed to determine whether artifact related to the implanted leads was present and, if so, its severity relative to surrounding myocardium.
In phantom studies, artifacts caused by pacing lead electrodes were barely noticeable, but artifacts arising from highly radioopaque ICD shock coil electrodes were clearly apparent. In the patient studies, no artifacts from pacing leads were identified. However, significant artifact was observed in 50% of the patient studies with ICD leads. In the affected areas, local myocardial uptake in PET/CT images using CT-AC was, on average, 30% higher than that in the corresponding PET images.
Although pacemaker leads do not appear to cause artifact in cardiac PET/CT images, ICD leads frequently do result in artifacts of sufficient magnitude to impact clinical image interpretation. Accordingly, software-based corrections in CT-AC algorithms appear necessary for accurate cardiac imaging with PET/CT.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 15750156</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Defibrillators, Implantable ; Electrodes, Implanted ; Heart - diagnostic imaging ; Humans ; Image Enhancement - methods ; Metals ; Pacemaker, Artificial ; Phantoms, Imaging ; Positron-Emission Tomography - instrumentation ; Positron-Emission Tomography - methods ; Reproducibility of Results ; Sensitivity and Specificity ; Subtraction Technique ; Tomography, X-Ray Computed - instrumentation ; Tomography, X-Ray Computed - methods</subject><ispartof>The Journal of nuclear medicine (1978), 2005-03, Vol.46 (3), p.436-443</ispartof><rights>Copyright Society of Nuclear Medicine Mar 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15750156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DiFilippo, Frank P</creatorcontrib><creatorcontrib>Brunken, Richard C</creatorcontrib><title>Do Implanted Pacemaker Leads and ICD Leads Cause Metal-Related Artifact in Cardiac PET/CT?</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Artifacts related to metallic implants are an established limitation of CT-based attenuation correction (CT-AC) in PET/CT. However, the impact of metallic components of pacemaker leads and implantable cardioverter defibrillator (ICD) leads on the accuracy of cardiac PET has not been evaluated. The goal of this study was to investigate the magnitude of artifacts related to pacing and defibrillation leads in both phantom and patient studies.
Images were acquired on a PET/CT scanner using CT-AC and were compared with those obtained on a dedicated PET scanner using transmission source-based attenuation correction. Phantoms consisting of pacemaker leads and ICD leads submerged in uniform background activity solution were imaged, and regions were analyzed to measure radionuclide concentrations at known lead locations relative to background. In addition, 15 cardiac 18F-FDG patients (having either pacing leads, defibrillation leads, or both) were imaged on both PET/CT and PET scanners. Images were visually and quantitatively assessed to determine whether artifact related to the implanted leads was present and, if so, its severity relative to surrounding myocardium.
In phantom studies, artifacts caused by pacing lead electrodes were barely noticeable, but artifacts arising from highly radioopaque ICD shock coil electrodes were clearly apparent. In the patient studies, no artifacts from pacing leads were identified. However, significant artifact was observed in 50% of the patient studies with ICD leads. In the affected areas, local myocardial uptake in PET/CT images using CT-AC was, on average, 30% higher than that in the corresponding PET images.
Although pacemaker leads do not appear to cause artifact in cardiac PET/CT images, ICD leads frequently do result in artifacts of sufficient magnitude to impact clinical image interpretation. Accordingly, software-based corrections in CT-AC algorithms appear necessary for accurate cardiac imaging with PET/CT.</description><subject>Defibrillators, Implantable</subject><subject>Electrodes, Implanted</subject><subject>Heart - diagnostic imaging</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Metals</subject><subject>Pacemaker, Artificial</subject><subject>Phantoms, Imaging</subject><subject>Positron-Emission Tomography - instrumentation</subject><subject>Positron-Emission Tomography - methods</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Subtraction Technique</subject><subject>Tomography, X-Ray Computed - instrumentation</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkE1Lw0AQhhdRbK3-BVk8eAvubjK7yUlKWrVQsUi9eAnTzdSm5qPuJoj_3hQrgqeXmfeZzyM2lBBCAFqbYzYUUssAQMCAnXm_FULoOI5P2UCCASFBD9nrpOGzaldi3VLOF2ipwndyfE6Ye451zmfp5BCl2Hnij9RiGTxTifuKsWuLNdqWF3Xvu7xAyxfT5U26vD1nJ2ssPV0cdMRe7qbL9CGYP93P0vE82Cht2gBNLwaVlcKaFSUQRQQKpEySGBRSmAORRkERANgEVJL0WakgxkjEvT9i1z99d6756Mi3WVV4S2V_EzWdz7SJYi2N6cGrf-C26Vzd75YpmSgltdhDlweoW1WUZztXVOi-st-X_Y3bFG-bz8JRVne2JHR7eltXkc7CLAp1-A1jUXI4</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>DiFilippo, Frank P</creator><creator>Brunken, Richard C</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Do Implanted Pacemaker Leads and ICD Leads Cause Metal-Related Artifact in Cardiac PET/CT?</title><author>DiFilippo, Frank P ; Brunken, Richard C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h267t-a72677a2c10c7be9544e5251199852ae3d5ee6a0e4555c952992ae1258a408ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Defibrillators, Implantable</topic><topic>Electrodes, Implanted</topic><topic>Heart - diagnostic imaging</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Metals</topic><topic>Pacemaker, Artificial</topic><topic>Phantoms, Imaging</topic><topic>Positron-Emission Tomography - instrumentation</topic><topic>Positron-Emission Tomography - methods</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Subtraction Technique</topic><topic>Tomography, X-Ray Computed - instrumentation</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DiFilippo, Frank P</creatorcontrib><creatorcontrib>Brunken, Richard C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DiFilippo, Frank P</au><au>Brunken, Richard C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do Implanted Pacemaker Leads and ICD Leads Cause Metal-Related Artifact in Cardiac PET/CT?</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>46</volume><issue>3</issue><spage>436</spage><epage>443</epage><pages>436-443</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><coden>JNMEAQ</coden><abstract>Artifacts related to metallic implants are an established limitation of CT-based attenuation correction (CT-AC) in PET/CT. However, the impact of metallic components of pacemaker leads and implantable cardioverter defibrillator (ICD) leads on the accuracy of cardiac PET has not been evaluated. The goal of this study was to investigate the magnitude of artifacts related to pacing and defibrillation leads in both phantom and patient studies.
Images were acquired on a PET/CT scanner using CT-AC and were compared with those obtained on a dedicated PET scanner using transmission source-based attenuation correction. Phantoms consisting of pacemaker leads and ICD leads submerged in uniform background activity solution were imaged, and regions were analyzed to measure radionuclide concentrations at known lead locations relative to background. In addition, 15 cardiac 18F-FDG patients (having either pacing leads, defibrillation leads, or both) were imaged on both PET/CT and PET scanners. Images were visually and quantitatively assessed to determine whether artifact related to the implanted leads was present and, if so, its severity relative to surrounding myocardium.
In phantom studies, artifacts caused by pacing lead electrodes were barely noticeable, but artifacts arising from highly radioopaque ICD shock coil electrodes were clearly apparent. In the patient studies, no artifacts from pacing leads were identified. However, significant artifact was observed in 50% of the patient studies with ICD leads. In the affected areas, local myocardial uptake in PET/CT images using CT-AC was, on average, 30% higher than that in the corresponding PET images.
Although pacemaker leads do not appear to cause artifact in cardiac PET/CT images, ICD leads frequently do result in artifacts of sufficient magnitude to impact clinical image interpretation. Accordingly, software-based corrections in CT-AC algorithms appear necessary for accurate cardiac imaging with PET/CT.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>15750156</pmid><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 2005-03, Vol.46 (3), p.436-443 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Defibrillators, Implantable Electrodes, Implanted Heart - diagnostic imaging Humans Image Enhancement - methods Metals Pacemaker, Artificial Phantoms, Imaging Positron-Emission Tomography - instrumentation Positron-Emission Tomography - methods Reproducibility of Results Sensitivity and Specificity Subtraction Technique Tomography, X-Ray Computed - instrumentation Tomography, X-Ray Computed - methods |
| title | Do Implanted Pacemaker Leads and ICD Leads Cause Metal-Related Artifact in Cardiac PET/CT? |
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