The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes
Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all....
Gespeichert in:
| Veröffentlicht in: | Diabetologia 2005-02, Vol.48 (2), p.309-316 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 316 |
|---|---|
| container_issue | 2 |
| container_start_page | 309 |
| container_title | Diabetologia |
| container_volume | 48 |
| creator | PÖYKKÖ, S. M UKKOLA, O KAUMA, H KELLOKOSKI, E HÖRKKÖ, S KESÄNIEMI, Y. A |
| description | Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all. The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association.
We analysed fasting plasma ghrelin and IGF-I concentrations of 1,004 middle-aged subjects of the population-based OPERA study. Insulin resistance was estimated using QUICKI.
IGF-I concentrations were negatively associated with ghrelin concentrations in the analysis of all subjects before (beta=-0.32, p |
| doi_str_mv | 10.1007/s00125-004-1635-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67485997</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>805847441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-744707f4c71265299aa224e941e44ec8fc2f3765264869bcbc76adf6ae26d4b93</originalsourceid><addsrcrecordid>eNpdkV1rFTEQhoNY7Gn1B3gjQbBXRpNsNh-XUmw9UPCmgnchm51tU_bjmNm1Pf--Wc-BgleTYZ55GfIQ8l7wL4Jz8xU5F7JmnCsmdFUz94pshKok40ra12Szjpmw-vcpOUN84JxXtdJvyKmotbWSuw15ur0HOsJdmNNfoAFxiqm8p5E2MD8CjHTXBxwCvbvP0KeRhrGl2-srtqUJ6TC1qUvQ0mZPpwYwzfvPNI24rGQuPc5hjPBvad7vgEraplCSAd-Sky70CO-O9Zz8uvp-e_mD3fy83l5-u2FR6XpmRinDTaeiEVLX0rkQpFTglAClINouyq4yZaKV1a6JTTQ6tJ0OIHWrGledk4tD7i5PfxbA2Q8JI_R9GGFa0GujbO2cKeDH_8CHacljuc1LUdmaV3aFxAGKeULM0PldTkPIey-4X534gxNfnPjViV8v-HAMXpoB2peNo4QCfDoCAWPou1z-LOELp2vNRQl7BqRAk74</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213850387</pqid></control><display><type>article</type><title>The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>PÖYKKÖ, S. M ; UKKOLA, O ; KAUMA, H ; KELLOKOSKI, E ; HÖRKKÖ, S ; KESÄNIEMI, Y. A</creator><creatorcontrib>PÖYKKÖ, S. M ; UKKOLA, O ; KAUMA, H ; KELLOKOSKI, E ; HÖRKKÖ, S ; KESÄNIEMI, Y. A</creatorcontrib><description>Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all. The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association.
We analysed fasting plasma ghrelin and IGF-I concentrations of 1,004 middle-aged subjects of the population-based OPERA study. Insulin resistance was estimated using QUICKI.
IGF-I concentrations were negatively associated with ghrelin concentrations in the analysis of all subjects before (beta=-0.32, p<0.001) and after adjustments for BMI, insulin levels, sex and age (beta=-0.40, p<0.001). The association was particularly strong in males and in the higher BMI tertiles. The degree of association varied in relation to the glycaemic status: no insulin resistance: r(2)=6.5% (p<0.001), insulin resistance without type 2 diabetes: r(2)=21.0% (p<0.001), type 2 diabetes: r(2)=25.4 (p<0.001). IGF-I levels explained larger proportion (r(2)=9.8%) of the variation in ghrelin concentrations compared to fasting insulin concentration (r(2)=3.0%) and BMI (r(2)=1.5%).
There is a negative and independent association between ghrelin and IGF-I concentrations in middle-aged subjects. The interaction between IGF-I and ghrelin is modified by obesity, IR and type 2 diabetes. Further studies are warranted to elucidate the role of ghrelin in the development of these states.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-004-1635-9</identifier><identifier>PMID: 15688209</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Arteriosclerosis - epidemiology ; Biological and medical sciences ; Cohort Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Finland - epidemiology ; Ghrelin ; Humans ; Insulin Resistance - physiology ; Insulin-Like Growth Factor I - metabolism ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Obesity ; Obesity - blood ; Peptide Hormones - blood ; Regression Analysis ; Reproducibility of Results ; Risk Factors ; Sex Characteristics</subject><ispartof>Diabetologia, 2005-02, Vol.48 (2), p.309-316</ispartof><rights>2005 INIST-CNRS</rights><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-744707f4c71265299aa224e941e44ec8fc2f3765264869bcbc76adf6ae26d4b93</citedby><cites>FETCH-LOGICAL-c465t-744707f4c71265299aa224e941e44ec8fc2f3765264869bcbc76adf6ae26d4b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16560116$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15688209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PÖYKKÖ, S. M</creatorcontrib><creatorcontrib>UKKOLA, O</creatorcontrib><creatorcontrib>KAUMA, H</creatorcontrib><creatorcontrib>KELLOKOSKI, E</creatorcontrib><creatorcontrib>HÖRKKÖ, S</creatorcontrib><creatorcontrib>KESÄNIEMI, Y. A</creatorcontrib><title>The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description>Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all. The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association.
We analysed fasting plasma ghrelin and IGF-I concentrations of 1,004 middle-aged subjects of the population-based OPERA study. Insulin resistance was estimated using QUICKI.
IGF-I concentrations were negatively associated with ghrelin concentrations in the analysis of all subjects before (beta=-0.32, p<0.001) and after adjustments for BMI, insulin levels, sex and age (beta=-0.40, p<0.001). The association was particularly strong in males and in the higher BMI tertiles. The degree of association varied in relation to the glycaemic status: no insulin resistance: r(2)=6.5% (p<0.001), insulin resistance without type 2 diabetes: r(2)=21.0% (p<0.001), type 2 diabetes: r(2)=25.4 (p<0.001). IGF-I levels explained larger proportion (r(2)=9.8%) of the variation in ghrelin concentrations compared to fasting insulin concentration (r(2)=3.0%) and BMI (r(2)=1.5%).
There is a negative and independent association between ghrelin and IGF-I concentrations in middle-aged subjects. The interaction between IGF-I and ghrelin is modified by obesity, IR and type 2 diabetes. Further studies are warranted to elucidate the role of ghrelin in the development of these states.</description><subject>Adult</subject><subject>Arteriosclerosis - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Ghrelin</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Peptide Hormones - blood</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Risk Factors</subject><subject>Sex Characteristics</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkV1rFTEQhoNY7Gn1B3gjQbBXRpNsNh-XUmw9UPCmgnchm51tU_bjmNm1Pf--Wc-BgleTYZ55GfIQ8l7wL4Jz8xU5F7JmnCsmdFUz94pshKok40ra12Szjpmw-vcpOUN84JxXtdJvyKmotbWSuw15ur0HOsJdmNNfoAFxiqm8p5E2MD8CjHTXBxwCvbvP0KeRhrGl2-srtqUJ6TC1qUvQ0mZPpwYwzfvPNI24rGQuPc5hjPBvad7vgEraplCSAd-Sky70CO-O9Zz8uvp-e_mD3fy83l5-u2FR6XpmRinDTaeiEVLX0rkQpFTglAClINouyq4yZaKV1a6JTTQ6tJ0OIHWrGledk4tD7i5PfxbA2Q8JI_R9GGFa0GujbO2cKeDH_8CHacljuc1LUdmaV3aFxAGKeULM0PldTkPIey-4X534gxNfnPjViV8v-HAMXpoB2peNo4QCfDoCAWPou1z-LOELp2vNRQl7BqRAk74</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>PÖYKKÖ, S. M</creator><creator>UKKOLA, O</creator><creator>KAUMA, H</creator><creator>KELLOKOSKI, E</creator><creator>HÖRKKÖ, S</creator><creator>KESÄNIEMI, Y. A</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes</title><author>PÖYKKÖ, S. M ; UKKOLA, O ; KAUMA, H ; KELLOKOSKI, E ; HÖRKKÖ, S ; KESÄNIEMI, Y. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-744707f4c71265299aa224e941e44ec8fc2f3765264869bcbc76adf6ae26d4b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Arteriosclerosis - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Ghrelin</topic><topic>Humans</topic><topic>Insulin Resistance - physiology</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Peptide Hormones - blood</topic><topic>Regression Analysis</topic><topic>Reproducibility of Results</topic><topic>Risk Factors</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PÖYKKÖ, S. M</creatorcontrib><creatorcontrib>UKKOLA, O</creatorcontrib><creatorcontrib>KAUMA, H</creatorcontrib><creatorcontrib>KELLOKOSKI, E</creatorcontrib><creatorcontrib>HÖRKKÖ, S</creatorcontrib><creatorcontrib>KESÄNIEMI, Y. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PÖYKKÖ, S. M</au><au>UKKOLA, O</au><au>KAUMA, H</au><au>KELLOKOSKI, E</au><au>HÖRKKÖ, S</au><au>KESÄNIEMI, Y. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes</atitle><jtitle>Diabetologia</jtitle><addtitle>Diabetologia</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>48</volume><issue>2</issue><spage>309</spage><epage>316</epage><pages>309-316</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all. The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association.
We analysed fasting plasma ghrelin and IGF-I concentrations of 1,004 middle-aged subjects of the population-based OPERA study. Insulin resistance was estimated using QUICKI.
IGF-I concentrations were negatively associated with ghrelin concentrations in the analysis of all subjects before (beta=-0.32, p<0.001) and after adjustments for BMI, insulin levels, sex and age (beta=-0.40, p<0.001). The association was particularly strong in males and in the higher BMI tertiles. The degree of association varied in relation to the glycaemic status: no insulin resistance: r(2)=6.5% (p<0.001), insulin resistance without type 2 diabetes: r(2)=21.0% (p<0.001), type 2 diabetes: r(2)=25.4 (p<0.001). IGF-I levels explained larger proportion (r(2)=9.8%) of the variation in ghrelin concentrations compared to fasting insulin concentration (r(2)=3.0%) and BMI (r(2)=1.5%).
There is a negative and independent association between ghrelin and IGF-I concentrations in middle-aged subjects. The interaction between IGF-I and ghrelin is modified by obesity, IR and type 2 diabetes. Further studies are warranted to elucidate the role of ghrelin in the development of these states.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15688209</pmid><doi>10.1007/s00125-004-1635-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-186X |
| ispartof | Diabetologia, 2005-02, Vol.48 (2), p.309-316 |
| issn | 0012-186X 1432-0428 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67485997 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Arteriosclerosis - epidemiology Biological and medical sciences Cohort Studies Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Finland - epidemiology Ghrelin Humans Insulin Resistance - physiology Insulin-Like Growth Factor I - metabolism Male Medical sciences Metabolic diseases Middle Aged Obesity Obesity - blood Peptide Hormones - blood Regression Analysis Reproducibility of Results Risk Factors Sex Characteristics |
| title | The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T04%3A23%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20negative%20association%20between%20plasma%20ghrelin%20and%20IGF-I%20is%20modified%20by%20obesity,%20insulin%20resistance%20and%20type%202%20diabetes&rft.jtitle=Diabetologia&rft.au=P%C3%96YKK%C3%96,%20S.%20M&rft.date=2005-02-01&rft.volume=48&rft.issue=2&rft.spage=309&rft.epage=316&rft.pages=309-316&rft.issn=0012-186X&rft.eissn=1432-0428&rft_id=info:doi/10.1007/s00125-004-1635-9&rft_dat=%3Cproquest_cross%3E805847441%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213850387&rft_id=info:pmid/15688209&rfr_iscdi=true |