Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian danes
The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim...
Gespeichert in:
| Veröffentlicht in: | Diabetologia 2005-02, Vol.48 (2), p.251-260 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 260 |
|---|---|
| container_issue | 2 |
| container_start_page | 251 |
| container_title | Diabetologia |
| container_volume | 48 |
| creator | HAMID, Y. H ROSE, C. S PEDERSEN, O URHAMMER, S. A GLÜMER, C NOLSØE, R KRISTIANSEN, O. P MANDRUP-POULSEN, T BORCH-JOHNSEN, K JORGENSEN, T HANSEN, T |
| description | The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.
Using analysis of PCR-generated primer extension products by mass spectrometry we examined -597 G/A, -572 G/C, and -174 G/C IL6 variants in the population-based Inter99 study cohort of middle-aged people (n=6,164) and in a group of type 2 diabetic patients (n=1,389).
The -174 G/C and -597 G/A polymorphisms were in strong linkage disequilibrium (R(2)=0.95). In the Inter99 cohort the -174 G-allele was associated with insulin resistance (p |
| doi_str_mv | 10.1007/s00125-004-1623-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67485965</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67485965</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-4562859dd33443e6242723546de6ad9be4d00e9148961e79d3cbd5e68b871b0f3</originalsourceid><addsrcrecordid>eNpdkUuLFTEQhYMoznX0B7iRIOguWnl2ZykXXzDgRsVdSCfVTMbuzph0M8y_N829OOCqIPWdw6kcQl5yeMcBuvcVgAvNABTjRkgGj8iBKykYKNE_Jod9zXhvfl2QZ7XeAIDUyjwlF1wbpQXYAyk_fUl-TXmpNI90vUaalhXLhNvvtDBDb0uec3ugviD1tebQcIz0Lq3XdES_bgX_SWdc_ZCnFGi9X2JT7m706Lfga_ILjX7B-pw8Gf1U8cV5XpIfnz5-P35hV98-fz1-uGJBWrsypY3otY1RSqUkGqFEJ_b8EY2PdkAVAdBy1VvDsbNRhiFqNP3Qd3yAUV6StyffdsKfDevq5lQDTlMLkbfqTKeav9ENfP0feJO3srRsTnDZK6sNbxA_QaHkWguO7rak2Zd7x8HtbbhTG6614fY2HDTNq7PxNswYHxTn72_AmzPga_DTWPwSUn3gjDbAoZd_Ab2BkiM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213849561</pqid></control><display><type>article</type><title>Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian danes</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>HAMID, Y. H ; ROSE, C. S ; PEDERSEN, O ; URHAMMER, S. A ; GLÜMER, C ; NOLSØE, R ; KRISTIANSEN, O. P ; MANDRUP-POULSEN, T ; BORCH-JOHNSEN, K ; JORGENSEN, T ; HANSEN, T</creator><creatorcontrib>HAMID, Y. H ; ROSE, C. S ; PEDERSEN, O ; URHAMMER, S. A ; GLÜMER, C ; NOLSØE, R ; KRISTIANSEN, O. P ; MANDRUP-POULSEN, T ; BORCH-JOHNSEN, K ; JORGENSEN, T ; HANSEN, T</creatorcontrib><description><![CDATA[The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.
Using analysis of PCR-generated primer extension products by mass spectrometry we examined -597 G/A, -572 G/C, and -174 G/C IL6 variants in the population-based Inter99 study cohort of middle-aged people (n=6,164) and in a group of type 2 diabetic patients (n=1,389).
The -174 G/C and -597 G/A polymorphisms were in strong linkage disequilibrium (R(2)=0.95). In the Inter99 cohort the -174 G-allele was associated with insulin resistance (p<0.02) and dyslipidaemia (p<0.007) whereas the C-allele of the -572 polymorphism was associated with increased serum insulin release during an OGTT (p<0.0005). Composite genotype or haplotype analyses of all 3 IL6 promoter variants showed associations with type 2 diabetes (p<0.002), obesity (p<0.02), and the metabolic syndrome (p<0.01).
The present studies suggest that single-nucleotide polymorphisms and composite genotypes or haplotypes of the IL6 promoter may be associated with several features of the metabolic syndrome in Caucasians.]]></description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-004-1623-0</identifier><identifier>PMID: 15645209</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Base Sequence ; Biological and medical sciences ; Cohort Studies ; Denmark ; Diabetes. Impaired glucose tolerance ; DNA Primers ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; European Continental Ancestry Group - genetics ; Female ; Gene Frequency ; Genetic Variation ; Genotype ; Humans ; Interleukin-6 - genetics ; Male ; Medical sciences ; Metabolic diseases ; Metabolic Syndrome - genetics ; Miscellaneous ; Other metabolic disorders ; Polymerase Chain Reaction - methods ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic</subject><ispartof>Diabetologia, 2005-02, Vol.48 (2), p.251-260</ispartof><rights>2005 INIST-CNRS</rights><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-4562859dd33443e6242723546de6ad9be4d00e9148961e79d3cbd5e68b871b0f3</citedby><cites>FETCH-LOGICAL-c399t-4562859dd33443e6242723546de6ad9be4d00e9148961e79d3cbd5e68b871b0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16560108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15645209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAMID, Y. H</creatorcontrib><creatorcontrib>ROSE, C. S</creatorcontrib><creatorcontrib>PEDERSEN, O</creatorcontrib><creatorcontrib>URHAMMER, S. A</creatorcontrib><creatorcontrib>GLÜMER, C</creatorcontrib><creatorcontrib>NOLSØE, R</creatorcontrib><creatorcontrib>KRISTIANSEN, O. P</creatorcontrib><creatorcontrib>MANDRUP-POULSEN, T</creatorcontrib><creatorcontrib>BORCH-JOHNSEN, K</creatorcontrib><creatorcontrib>JORGENSEN, T</creatorcontrib><creatorcontrib>HANSEN, T</creatorcontrib><title>Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian danes</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description><![CDATA[The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.
Using analysis of PCR-generated primer extension products by mass spectrometry we examined -597 G/A, -572 G/C, and -174 G/C IL6 variants in the population-based Inter99 study cohort of middle-aged people (n=6,164) and in a group of type 2 diabetic patients (n=1,389).
The -174 G/C and -597 G/A polymorphisms were in strong linkage disequilibrium (R(2)=0.95). In the Inter99 cohort the -174 G-allele was associated with insulin resistance (p<0.02) and dyslipidaemia (p<0.007) whereas the C-allele of the -572 polymorphism was associated with increased serum insulin release during an OGTT (p<0.0005). Composite genotype or haplotype analyses of all 3 IL6 promoter variants showed associations with type 2 diabetes (p<0.002), obesity (p<0.02), and the metabolic syndrome (p<0.01).
The present studies suggest that single-nucleotide polymorphisms and composite genotypes or haplotypes of the IL6 promoter may be associated with several features of the metabolic syndrome in Caucasians.]]></description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Denmark</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>DNA Primers</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Humans</subject><subject>Interleukin-6 - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic Syndrome - genetics</subject><subject>Miscellaneous</subject><subject>Other metabolic disorders</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkUuLFTEQhYMoznX0B7iRIOguWnl2ZykXXzDgRsVdSCfVTMbuzph0M8y_N829OOCqIPWdw6kcQl5yeMcBuvcVgAvNABTjRkgGj8iBKykYKNE_Jod9zXhvfl2QZ7XeAIDUyjwlF1wbpQXYAyk_fUl-TXmpNI90vUaalhXLhNvvtDBDb0uec3ugviD1tebQcIz0Lq3XdES_bgX_SWdc_ZCnFGi9X2JT7m706Lfga_ILjX7B-pw8Gf1U8cV5XpIfnz5-P35hV98-fz1-uGJBWrsypY3otY1RSqUkGqFEJ_b8EY2PdkAVAdBy1VvDsbNRhiFqNP3Qd3yAUV6StyffdsKfDevq5lQDTlMLkbfqTKeav9ENfP0feJO3srRsTnDZK6sNbxA_QaHkWguO7rak2Zd7x8HtbbhTG6614fY2HDTNq7PxNswYHxTn72_AmzPga_DTWPwSUn3gjDbAoZd_Ab2BkiM</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>HAMID, Y. H</creator><creator>ROSE, C. S</creator><creator>PEDERSEN, O</creator><creator>URHAMMER, S. A</creator><creator>GLÜMER, C</creator><creator>NOLSØE, R</creator><creator>KRISTIANSEN, O. P</creator><creator>MANDRUP-POULSEN, T</creator><creator>BORCH-JOHNSEN, K</creator><creator>JORGENSEN, T</creator><creator>HANSEN, T</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian danes</title><author>HAMID, Y. H ; ROSE, C. S ; PEDERSEN, O ; URHAMMER, S. A ; GLÜMER, C ; NOLSØE, R ; KRISTIANSEN, O. P ; MANDRUP-POULSEN, T ; BORCH-JOHNSEN, K ; JORGENSEN, T ; HANSEN, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-4562859dd33443e6242723546de6ad9be4d00e9148961e79d3cbd5e68b871b0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Denmark</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>DNA Primers</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Humans</topic><topic>Interleukin-6 - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic Syndrome - genetics</topic><topic>Miscellaneous</topic><topic>Other metabolic disorders</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAMID, Y. H</creatorcontrib><creatorcontrib>ROSE, C. S</creatorcontrib><creatorcontrib>PEDERSEN, O</creatorcontrib><creatorcontrib>URHAMMER, S. A</creatorcontrib><creatorcontrib>GLÜMER, C</creatorcontrib><creatorcontrib>NOLSØE, R</creatorcontrib><creatorcontrib>KRISTIANSEN, O. P</creatorcontrib><creatorcontrib>MANDRUP-POULSEN, T</creatorcontrib><creatorcontrib>BORCH-JOHNSEN, K</creatorcontrib><creatorcontrib>JORGENSEN, T</creatorcontrib><creatorcontrib>HANSEN, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAMID, Y. H</au><au>ROSE, C. S</au><au>PEDERSEN, O</au><au>URHAMMER, S. A</au><au>GLÜMER, C</au><au>NOLSØE, R</au><au>KRISTIANSEN, O. P</au><au>MANDRUP-POULSEN, T</au><au>BORCH-JOHNSEN, K</au><au>JORGENSEN, T</au><au>HANSEN, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian danes</atitle><jtitle>Diabetologia</jtitle><addtitle>Diabetologia</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>48</volume><issue>2</issue><spage>251</spage><epage>260</epage><pages>251-260</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract><![CDATA[The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.
Using analysis of PCR-generated primer extension products by mass spectrometry we examined -597 G/A, -572 G/C, and -174 G/C IL6 variants in the population-based Inter99 study cohort of middle-aged people (n=6,164) and in a group of type 2 diabetic patients (n=1,389).
The -174 G/C and -597 G/A polymorphisms were in strong linkage disequilibrium (R(2)=0.95). In the Inter99 cohort the -174 G-allele was associated with insulin resistance (p<0.02) and dyslipidaemia (p<0.007) whereas the C-allele of the -572 polymorphism was associated with increased serum insulin release during an OGTT (p<0.0005). Composite genotype or haplotype analyses of all 3 IL6 promoter variants showed associations with type 2 diabetes (p<0.002), obesity (p<0.02), and the metabolic syndrome (p<0.01).
The present studies suggest that single-nucleotide polymorphisms and composite genotypes or haplotypes of the IL6 promoter may be associated with several features of the metabolic syndrome in Caucasians.]]></abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15645209</pmid><doi>10.1007/s00125-004-1623-0</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-186X |
| ispartof | Diabetologia, 2005-02, Vol.48 (2), p.251-260 |
| issn | 0012-186X 1432-0428 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67485965 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Base Sequence Biological and medical sciences Cohort Studies Denmark Diabetes. Impaired glucose tolerance DNA Primers Endocrine pancreas. Apud cells (diseases) Endocrinopathies European Continental Ancestry Group - genetics Female Gene Frequency Genetic Variation Genotype Humans Interleukin-6 - genetics Male Medical sciences Metabolic diseases Metabolic Syndrome - genetics Miscellaneous Other metabolic disorders Polymerase Chain Reaction - methods Polymorphism, Single Nucleotide Promoter Regions, Genetic |
| title | Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian danes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T00%3A44%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Variations%20of%20the%20interleukin-6%20promoter%20are%20associated%20with%20features%20of%20the%20metabolic%20syndrome%20in%20Caucasian%20danes&rft.jtitle=Diabetologia&rft.au=HAMID,%20Y.%20H&rft.date=2005-02-01&rft.volume=48&rft.issue=2&rft.spage=251&rft.epage=260&rft.pages=251-260&rft.issn=0012-186X&rft.eissn=1432-0428&rft_id=info:doi/10.1007/s00125-004-1623-0&rft_dat=%3Cproquest_cross%3E67485965%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213849561&rft_id=info:pmid/15645209&rfr_iscdi=true |