High-Density Substrate Mapping in Brugada Syndrome: Combined Role of Conduction and Repolarization Heterogeneities in Arrhythmogenesis

Two principal mechanisms are thought to be responsible for Brugada syndrome (BS): (1) right ventricular (RV) conduction delay and (2) RV subepicardial action potential shortening. This in vivo high-density mapping study evaluated the conduction and repolarization properties of the RV in BS subjects....

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2009-07, Vol.120 (2), p.106-117
Hauptverfasser:	LAMBIASE, P. D, AHMED, A. K, CIACCIO, E. J, BRUGADA, R, LIZOTTE, E, CHAUBEY, S, BEN-SIMON, Ron, CHOW, A. W, LOWE, M. D, MCKENNA, W. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Adult Aged Arrhythmias, Cardiac - physiopathology Biological and medical sciences Blood and lymphatic vessels Brugada Syndrome - genetics Brugada Syndrome - physiopathology Cardiology. Vascular system Case-Control Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Electrocardiography Electrophysiologic Techniques, Cardiac Endocardium - physiopathology Female Genetic Testing Heart Conduction System - physiopathology Humans Injuries of the limb. Injuries of the spine Male Medical sciences Middle Aged Muscle Proteins - genetics Mutation - genetics NAV1.5 Voltage-Gated Sodium Channel Sodium Channels - genetics Tachycardia, Ventricular - physiopathology Traumas. Diseases due to physical agents
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