Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate

Background Mechanisms of radioresistance in rectal cancer remain unclear. Objectives To determine mechanisms of radioresistance in rectal cancer cells and to assess the role of the nitric oxide donor DETANONOate as a radiosensitizing agent. Methods Survival was determined by clonogenic assays, apopt...

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Veröffentlicht in:	Journal of surgical oncology 2009-08, Vol.100 (2), p.149-158
Hauptverfasser:	Gao, Xiaohuan, Saha, Debabrata, Kapur, Payal, Anthony, Thomas, Livingston, Edward H., Huerta, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BAX Bcl-2 bcl-2-Associated X Protein - analysis Dose-Response Relationship, Drug HCT116 Cells HT29 Cells Humans Inhibitor of Apoptosis Proteins Mice Mice, SCID Microtubule-Associated Proteins - physiology Nitric Oxide Donors - pharmacology Nitroso Compounds - pharmacology p21 p27 PARP-1 Radiation-Sensitizing Agents - pharmacology Tumor Suppressor Protein p53 - physiology Xenograft Model Antitumor Assays
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