Inhibitory Effects of Amino-Acid Fluids on Drug Binding to Site II of Human Serum Albumin in Vitro

The effects of amino-acid fluids on ligand binding to human serum albumin (HSA) were investigated by fluorescence and ultrafiltration techniques. Warfarin and dansylsarcosine were used as the site marker fluorescence probes for site I and site II of HSA, respectively. Amino-acid fluids specifically...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2005, Vol.28(3), pp.549-552
Hauptverfasser:	Yamasaki, Keishi, Kuga, Noriyuki, Takamura, Norito, Furuya, Yumiko, Hidaka, Muneaki, Iwakiri, Tomomi, Nishii, Ryuuichi, Okumura, Manabu, Kodama, Hirofumi, Kawai, Keiichi, Arimori, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult albumin amino acid Amino Acids - metabolism Amino Acids - pharmacology binding site Binding Sites - physiology drug interaction Humans Male Parenteral Nutrition Pharmaceutical Preparations - metabolism protein binding Receptors, Drug - antagonists & inhibitors Receptors, Drug - metabolism Serum Albumin - antagonists & inhibitors Serum Albumin - metabolism
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