A Bovine Parainfluenza Virus Type 3 Vaccine Is Safe and Immunogenic in Early Infancy

BackgroundA phase 2 trial was conducted to assess in young infants the safety, tolerability, infectivity, and immunogenicity of multiple doses of an intranasal vaccine using bovine parainfluenza virus type 3 (bPIV3) MethodsOne hundred ninety-two healthy 2-month-old infants were randomized 1:1:1 to r...

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Veröffentlicht in:	The Journal of infectious diseases 2005-04, Vol.191 (7), p.1116-1122
Hauptverfasser:	Greenberg, David P., Walker, Robert E., Lee, Min-Shi, Reisinger, Keith S., Ward, Joel I., Yogev, Ram, Blatter, Mark M., Yeh, Sylvia H., Karron, Ruth A., Sangli, Chithra, Eubank, Lane, Coelingh, Kathleen L., Cordova, Julie M., August, Marilyn J., Mehta, Harshvardhan B., Chen, Wendy, Mendelman, Paul M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animal age determination Antibodies Antibodies, Viral - blood Applied microbiology Biological and medical sciences Cough Dosage Fever Fundamental and applied biological sciences. Psychology Hemagglutination Inhibition Tests Human parainfluenza virus 3 Humans Infant Infectious diseases Medical sciences Microbiology Miscellaneous Nasal Lavage Fluid - immunology Nasal Lavage Fluid - virology Parainfluenza Vaccines - administration & dosage Parainfluenza Vaccines - adverse effects Parainfluenza Vaccines - immunology Parainfluenza Virus 3, Bovine - immunology Parainfluenza Virus 3, Human - immunology Placebos Respirovirus Infections - prevention & control Ungulates United States Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology Viruses
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