New light on the serotonergic paradox in the rat circadian system

The main mammalian circadian clock, localized in the suprachiasmatic nuclei can be synchronized not only with light, but also with serotonergic activation. Serotonergic agonists and serotonin reuptake inhibitors (e.g., fluoxetine) have a non-photic influence (shifting effects during daytime and atte...

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Veröffentlicht in:	Journal of neurochemistry 2009-07, Vol.110 (1), p.231-243
Hauptverfasser:	Cuesta, Marc, Clesse, Daniel, Pévet, Paul, Challet, Etienne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and medical sciences Biological Clocks - drug effects Biological Clocks - genetics Brain - cytology Brain - metabolism circadian Circadian rhythm Circadian Rhythm - drug effects Circadian Rhythm - genetics Darkness Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fluoxetine - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Intracellular Signaling Peptides and Proteins - genetics Light Male Medical sciences Neural Pathways - drug effects Neural Pathways - metabolism Neurology Neurons - drug effects Neurons - metabolism Neurotransmitters non-photic Nuclear Receptor Subfamily 1, Group F, Member 2 Period Circadian Proteins photic photic-like Rats Rats, Long-Evans Receptors, Cytoplasmic and Nuclear - genetics Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Rodents serotonin Serotonin - metabolism Serotonin Receptor Agonists - pharmacology Serotonin Uptake Inhibitors - pharmacology suprachiasmatic Suprachiasmatic Nucleus - drug effects Suprachiasmatic Nucleus - metabolism Synaptic Transmission - physiology Vertebrates: endocrinology
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