Platelet-Derived Growth Factor C Induces Liver Fibrosis, Steatosis, and Hepatocellular Carcinoma

Members of the platelet-derived growth factor (PDGF) ligand family are known to play important roles in wound healing and fibrotic disease. We show that both transient and stable expression of PDGF-C results in the development of liver fibrosis consisting of the deposition of collagen in a pericellu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-03, Vol.102 (9), p.3389-3394
Hauptverfasser:	Campbell, Jean S., Hughes, Steven D., Gilbertson, Debra G., Palmer, Thomas E., Holdren, Matthew S., Haran, Aaron C., Odell, Melissa M., Bauer, Renay L., Ren, Hong-Ping, Haugen, Harald S., Yeh, Matthew M., Fausto, Nelson, Krebs, Edwin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Antibodies Biological Sciences Blood Cancer Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - pathology Collagens Fatty Liver - etiology Fatty Liver - pathology Fibrosis Hepatocellular carcinoma Hepatocytes Humans Immunohistochemistry Liver Liver cirrhosis Liver Cirrhosis - etiology Liver Cirrhosis - genetics Liver Cirrhosis - pathology Liver Neoplasms - etiology Liver Neoplasms - pathology Lymphokines Medical research Messenger RNA Mice Mice, Transgenic Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - physiology Proteins Receptors Rodents
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