A Synthetic Pathway to Either Enantiomer of Merrilactone A
A route to enantioenriched merrilactone A was found via intermediate 3. A degradation pathway in which meso compound 1 is transformed into key intermediate 2 in four steps occurs with full regiocontrol and promising enantiocontrol. A key feature of this reaction sequence is the desymmetrization of 1...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2005-02, Vol.44 (10), p.1511-1513 |
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| container_issue | 10 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 44 |
| creator | Meng, Zhaoyang Danishefsky, Samuel J. |
| description | A route to enantioenriched merrilactone A was found via intermediate 3. A degradation pathway in which meso compound 1 is transformed into key intermediate 2 in four steps occurs with full regiocontrol and promising enantiocontrol. A key feature of this reaction sequence is the desymmetrization of 1 through an intramolecular asymmetric ring‐opening reaction. |
| doi_str_mv | 10.1002/anie.200462509 |
| format | Article |
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| ispartof | Angewandte Chemie International Edition, 2005-02, Vol.44 (10), p.1511-1513 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | asymmetric synthesis enantioselectivity Lactones - chemical synthesis natural products regioselectivity Sesquiterpenes - chemical synthesis Stereoisomerism synthetic methods |
| title | A Synthetic Pathway to Either Enantiomer of Merrilactone A |
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