Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells

ABSTRACT Heme oxygenase‐1 (HO‐1), which degrades heme into three products (carbon monoxide, free iron, and biliverdin), plays a protective role in many models of disease via its anti‐inflammatory, anti‐apoptotic, and anti‐proliferative actions. Overexpression of HO‐1 has been shown to suppress immun...

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Veröffentlicht in:	The FASEB journal 2005-03, Vol.19 (3), p.458-460
Hauptverfasser:	McDaid, James, Yamashita, Kenichiro, Chora, Angelo, Öllinger, Robert, Strom, Terry B, Li, Xian C, Bach, Fritz H, Soares, Miguel P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - enzymology CD4-Positive T-Lymphocytes - immunology Cell Death cellular activation Enzyme Induction - drug effects fas Receptor - analysis Gene Expression - drug effects Heme Oxygenase (Decyclizing) - biosynthesis Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - physiology Heme Oxygenase-1 Histocytochemistry Immunohistochemistry Interleukin-2 - analysis Interleukin-2 - secretion Isoantigens - immunology Lymphocyte Activation - physiology Lymphocyte Culture Test, Mixed Male Membrane Proteins Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Mutant Strains Mice, Transgenic Ovalbumin - genetics RNA, Messenger - analysis T lymphocytes
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