Copper absorption from foods labelled intrinsically and extrinsically with Cu-65 stable isotope
Objective: To determine copper absorption from copper containing foods labelled either intrinsically or extrinsically with a highly enriched Cu-65 stable isotope label. Design: A longitudinal cross-over study. Setting: The study was conducted at the Institute of Food Research, Human Nutrition Unit,...
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| Veröffentlicht in: | European journal of clinical nutrition 2005-03, Vol.59 (3), p.363-368 |
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| creator | Harvey, L.J Dainty, J.R Beattie, J.H Majsak-Newman, G Wharf, S.G Reid, M.D Fairweather-Tait, S.J |
| description | Objective: To determine copper absorption from copper containing foods labelled either intrinsically or extrinsically with a highly enriched Cu-65 stable isotope label. Design: A longitudinal cross-over study. Setting: The study was conducted at the Institute of Food Research, Human Nutrition Unit, Norwich, UK. Subjects: Subjects were recruited locally via advertisements placed around the Norwich Research Park. A total of 10 volunteers (nine female, one male) took part in the study, but not all volunteers completed each of the test meals. Interventions: A highly enriched Cu-65 stable isotope label was administered to volunteers in the form of a reference dose or in breakfast test meals consisting of red wine, soya beans, mushrooms or sunflower seeds. Faecal monitoring and mass spectrometry techniques were used to estimate the relative quantities of copper absorbed from the different test meals. Results: True copper absorption from the reference dose (54%) was similar to extrinsically labelled red wine (49%) and intrinsically labelled sunflower seeds (52%), but significantly higher than extrinsically labelled mushrooms (35%), intrinsically (29%) and extrinsically (15%) labelled soya beans and extrinsically labelled sunflower seed (32%) test meals. Conclusions: The use of Cu-65 extrinsic labels in copper absorption studies requires validation according to the food being examined; intrinsic and extrinsic labelling produced significantly different results for sunflower seeds. |
| doi_str_mv | 10.1038/sj.ejcn.1602082 |
| format | Article |
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Design: A longitudinal cross-over study. Setting: The study was conducted at the Institute of Food Research, Human Nutrition Unit, Norwich, UK. Subjects: Subjects were recruited locally via advertisements placed around the Norwich Research Park. A total of 10 volunteers (nine female, one male) took part in the study, but not all volunteers completed each of the test meals. Interventions: A highly enriched Cu-65 stable isotope label was administered to volunteers in the form of a reference dose or in breakfast test meals consisting of red wine, soya beans, mushrooms or sunflower seeds. Faecal monitoring and mass spectrometry techniques were used to estimate the relative quantities of copper absorbed from the different test meals. Results: True copper absorption from the reference dose (54%) was similar to extrinsically labelled red wine (49%) and intrinsically labelled sunflower seeds (52%), but significantly higher than extrinsically labelled mushrooms (35%), intrinsically (29%) and extrinsically (15%) labelled soya beans and extrinsically labelled sunflower seed (32%) test meals. Conclusions: The use of Cu-65 extrinsic labels in copper absorption studies requires validation according to the food being examined; intrinsic and extrinsic labelling produced significantly different results for sunflower seeds.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1602082</identifier><identifier>PMID: 15523483</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Absorption ; Adult ; adults ; Beans ; Biological and medical sciences ; Biological Availability ; Biological research ; Biotechnology ; breakfast ; Clinical Nutrition ; Copper ; Copper - administration & dosage ; Copper - pharmacokinetics ; Cross-Over Studies ; dietary minerals ; Epidemiology ; feces ; Feces - chemistry ; Feeding. Feeding behavior ; Female ; Food ; Food Analysis ; Fundamental and applied biological sciences. Psychology ; Helianthus ; Human nutrition ; Humans ; Internal Medicine ; Intestinal Absorption ; Isotopes ; Labeling ; Labels ; Longitudinal Studies ; Male ; Mass spectrometry ; Mass Spectrometry - methods ; Mass spectroscopy ; Meals ; Medicine ; Medicine & Public Health ; men ; Metabolic Diseases ; mineral metabolism ; Mushrooms ; nutrient intake ; Nutrition ; original-communication ; Public Health ; red wines ; Reproducibility of Results ; Research parks ; Seeds ; Soybeans ; Stable isotopes ; sunflower seed ; Sunflowers ; test meals ; validity ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Wine ; women</subject><ispartof>European journal of clinical nutrition, 2005-03, Vol.59 (3), p.363-368</ispartof><rights>Springer Nature Limited 2005</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Nature Publishing Group 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c589t-c86649d4a597dbfdb5b339896c5958f5611650247cb58a0bd0d37d034fd355993</citedby><cites>FETCH-LOGICAL-c589t-c86649d4a597dbfdb5b339896c5958f5611650247cb58a0bd0d37d034fd355993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ejcn.1602082$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ejcn.1602082$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16585440$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15523483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harvey, L.J</creatorcontrib><creatorcontrib>Dainty, J.R</creatorcontrib><creatorcontrib>Beattie, J.H</creatorcontrib><creatorcontrib>Majsak-Newman, G</creatorcontrib><creatorcontrib>Wharf, S.G</creatorcontrib><creatorcontrib>Reid, M.D</creatorcontrib><creatorcontrib>Fairweather-Tait, S.J</creatorcontrib><title>Copper absorption from foods labelled intrinsically and extrinsically with Cu-65 stable isotope</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Objective: To determine copper absorption from copper containing foods labelled either intrinsically or extrinsically with a highly enriched Cu-65 stable isotope label. Design: A longitudinal cross-over study. Setting: The study was conducted at the Institute of Food Research, Human Nutrition Unit, Norwich, UK. Subjects: Subjects were recruited locally via advertisements placed around the Norwich Research Park. A total of 10 volunteers (nine female, one male) took part in the study, but not all volunteers completed each of the test meals. Interventions: A highly enriched Cu-65 stable isotope label was administered to volunteers in the form of a reference dose or in breakfast test meals consisting of red wine, soya beans, mushrooms or sunflower seeds. Faecal monitoring and mass spectrometry techniques were used to estimate the relative quantities of copper absorbed from the different test meals. Results: True copper absorption from the reference dose (54%) was similar to extrinsically labelled red wine (49%) and intrinsically labelled sunflower seeds (52%), but significantly higher than extrinsically labelled mushrooms (35%), intrinsically (29%) and extrinsically (15%) labelled soya beans and extrinsically labelled sunflower seed (32%) test meals. Conclusions: The use of Cu-65 extrinsic labels in copper absorption studies requires validation according to the food being examined; intrinsic and extrinsic labelling produced significantly different results for sunflower seeds.</description><subject>Absorption</subject><subject>Adult</subject><subject>adults</subject><subject>Beans</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Biological research</subject><subject>Biotechnology</subject><subject>breakfast</subject><subject>Clinical Nutrition</subject><subject>Copper</subject><subject>Copper - administration & dosage</subject><subject>Copper - pharmacokinetics</subject><subject>Cross-Over Studies</subject><subject>dietary minerals</subject><subject>Epidemiology</subject><subject>feces</subject><subject>Feces - chemistry</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food</subject><subject>Food Analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Helianthus</subject><subject>Human nutrition</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Intestinal Absorption</subject><subject>Isotopes</subject><subject>Labeling</subject><subject>Labels</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Mass spectroscopy</subject><subject>Meals</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>men</subject><subject>Metabolic Diseases</subject><subject>mineral metabolism</subject><subject>Mushrooms</subject><subject>nutrient intake</subject><subject>Nutrition</subject><subject>original-communication</subject><subject>Public Health</subject><subject>red wines</subject><subject>Reproducibility of Results</subject><subject>Research parks</subject><subject>Seeds</subject><subject>Soybeans</subject><subject>Stable isotopes</subject><subject>sunflower seed</subject><subject>Sunflowers</subject><subject>test meals</subject><subject>validity</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Wine</subject><subject>women</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kstv1DAQxiMEokvhzAmIhOgtWzt-xcdqxUuqxAF6thw_dr3y2sFOVPrf41WCdkFFPlia7_fNjD1TVa8hWEOAuuu8X5u9CmtIQQu69km1gpjRhlAMnlYrwAluEADsonqR8x6AIrL2eXUBCWkR7tCqEps4DCbVss8xDaOLobYpHmobo861l73x3ujahTG5kJ2S3j_UMuja_DqP3LtxV2-mhpI6j7L3pnY5jnEwL6tnVvpsXi33ZXX36eOPzZfm9tvnr5ub20aRjo-N6ijFXGNJONO91T3pEeIdp4pw0llCIaQEtJipnnQS9BpoxDRA2GpECOfosrqa8w4p_pxMHsXBZVWal8HEKQvKcAcRgwV8_w-4j1MKpTfRUtxSThDHhWpmaiu9ES7YOCaptiaYJH0MxroSvoGcMIZaQAq_foQvR5uDU48ars4MOyP9uMvRT8cJ5L_B6xlUKeacjBVDcgeZHgQE4rgDIu_FcQfEsgPF8XZ54dQfjD7xy9AL8GEBZC7js0kG5fKJo6QjGIPCgZnLRQpbk05f9f_ab2ZLkOOUzFnOP_q7WbcyCrlNpezd9xZABCBoKeMA_QYUH9ui</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Harvey, L.J</creator><creator>Dainty, J.R</creator><creator>Beattie, J.H</creator><creator>Majsak-Newman, G</creator><creator>Wharf, S.G</creator><creator>Reid, M.D</creator><creator>Fairweather-Tait, S.J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Copper absorption from foods labelled intrinsically and extrinsically with Cu-65 stable isotope</title><author>Harvey, L.J ; Dainty, J.R ; Beattie, J.H ; Majsak-Newman, G ; Wharf, S.G ; Reid, M.D ; Fairweather-Tait, S.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-c86649d4a597dbfdb5b339896c5958f5611650247cb58a0bd0d37d034fd355993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Absorption</topic><topic>Adult</topic><topic>adults</topic><topic>Beans</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Biological research</topic><topic>Biotechnology</topic><topic>breakfast</topic><topic>Clinical Nutrition</topic><topic>Copper</topic><topic>Copper - administration & dosage</topic><topic>Copper - pharmacokinetics</topic><topic>Cross-Over Studies</topic><topic>dietary minerals</topic><topic>Epidemiology</topic><topic>feces</topic><topic>Feces - chemistry</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food</topic><topic>Food Analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Helianthus</topic><topic>Human nutrition</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Intestinal Absorption</topic><topic>Isotopes</topic><topic>Labeling</topic><topic>Labels</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Mass spectroscopy</topic><topic>Meals</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>men</topic><topic>Metabolic Diseases</topic><topic>mineral metabolism</topic><topic>Mushrooms</topic><topic>nutrient intake</topic><topic>Nutrition</topic><topic>original-communication</topic><topic>Public Health</topic><topic>red wines</topic><topic>Reproducibility of Results</topic><topic>Research parks</topic><topic>Seeds</topic><topic>Soybeans</topic><topic>Stable isotopes</topic><topic>sunflower seed</topic><topic>Sunflowers</topic><topic>test meals</topic><topic>validity</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Wine</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harvey, L.J</creatorcontrib><creatorcontrib>Dainty, J.R</creatorcontrib><creatorcontrib>Beattie, J.H</creatorcontrib><creatorcontrib>Majsak-Newman, G</creatorcontrib><creatorcontrib>Wharf, S.G</creatorcontrib><creatorcontrib>Reid, M.D</creatorcontrib><creatorcontrib>Fairweather-Tait, S.J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harvey, L.J</au><au>Dainty, J.R</au><au>Beattie, J.H</au><au>Majsak-Newman, G</au><au>Wharf, S.G</au><au>Reid, M.D</au><au>Fairweather-Tait, S.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Copper absorption from foods labelled intrinsically and extrinsically with Cu-65 stable isotope</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>59</volume><issue>3</issue><spage>363</spage><epage>368</epage><pages>363-368</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Objective: To determine copper absorption from copper containing foods labelled either intrinsically or extrinsically with a highly enriched Cu-65 stable isotope label. Design: A longitudinal cross-over study. Setting: The study was conducted at the Institute of Food Research, Human Nutrition Unit, Norwich, UK. Subjects: Subjects were recruited locally via advertisements placed around the Norwich Research Park. A total of 10 volunteers (nine female, one male) took part in the study, but not all volunteers completed each of the test meals. Interventions: A highly enriched Cu-65 stable isotope label was administered to volunteers in the form of a reference dose or in breakfast test meals consisting of red wine, soya beans, mushrooms or sunflower seeds. Faecal monitoring and mass spectrometry techniques were used to estimate the relative quantities of copper absorbed from the different test meals. Results: True copper absorption from the reference dose (54%) was similar to extrinsically labelled red wine (49%) and intrinsically labelled sunflower seeds (52%), but significantly higher than extrinsically labelled mushrooms (35%), intrinsically (29%) and extrinsically (15%) labelled soya beans and extrinsically labelled sunflower seed (32%) test meals. Conclusions: The use of Cu-65 extrinsic labels in copper absorption studies requires validation according to the food being examined; intrinsic and extrinsic labelling produced significantly different results for sunflower seeds.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15523483</pmid><doi>10.1038/sj.ejcn.1602082</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of clinical nutrition, 2005-03, Vol.59 (3), p.363-368 |
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| source | MEDLINE; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Absorption Adult adults Beans Biological and medical sciences Biological Availability Biological research Biotechnology breakfast Clinical Nutrition Copper Copper - administration & dosage Copper - pharmacokinetics Cross-Over Studies dietary minerals Epidemiology feces Feces - chemistry Feeding. Feeding behavior Female Food Food Analysis Fundamental and applied biological sciences. Psychology Helianthus Human nutrition Humans Internal Medicine Intestinal Absorption Isotopes Labeling Labels Longitudinal Studies Male Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Meals Medicine Medicine & Public Health men Metabolic Diseases mineral metabolism Mushrooms nutrient intake Nutrition original-communication Public Health red wines Reproducibility of Results Research parks Seeds Soybeans Stable isotopes sunflower seed Sunflowers test meals validity Vertebrates: anatomy and physiology, studies on body, several organs or systems Wine women |
| title | Copper absorption from foods labelled intrinsically and extrinsically with Cu-65 stable isotope |
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