Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides

The biological activity for a set of melanocortin-4 receptor (MC4R) agonists containing a piperazine core with an ortho-substituted aryl sulfonamide is described. Compounds from this set had binding and functional activities at MC4R less than 30 nM. The most selective compound in this series was >...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-03, Vol.15 (6), p.1623-1627
Hauptverfasser:	Fotsch, Christopher, Han, Nianhe, Arasasingham, Premilla, Bo, Yunxin, Carmouche, Michelle, Chen, Ning, Davis, James, Goldberg, Martin H., Hale, Clarence, Hsieh, Feng-Yin, Kelly, Michael G., Liu, Qingyian, Norman, Mark H., Smith, Duncan M., Stec, Markian, Tamayo, Nuria, Xi, Ning, Xu, Shimin, Bannon, Anthony W., Baumgartner, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Biological and medical sciences Feeding Feeding Behavior - drug effects Humans In Vitro Techniques Male Medical sciences Melanocortin subtype 4 receptor Mice Mice, Inbred C57BL Miscellaneous Molecular Structure Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Piperazine Piperazines - chemistry Piperazines - pharmacology Protein Binding Receptor, Melanocortin, Type 4 - agonists Structure-Activity Relationship Sulfonamides - chemistry Sulfonamides - pharmacology
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