Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

Aims/hypothesis Macrophage-mediated renal injury plays an important role in the development of diabetic nephropathy. Colony-stimulating factor (CSF)-1 is a cytokine that is produced in diabetic kidneys and promotes macrophage accumulation, activation and survival. CSF-1 acts exclusively through the...

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Veröffentlicht in:	Diabetologia 2009-08, Vol.52 (8), p.1669-1679
Hauptverfasser:	Lim, A. K. H, Ma, F. Y, Nikolic-Paterson, D. J, Thomas, M. C, Hurst, L. A, Tesch, G. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Associated diseases and complications Biological and medical sciences Cell Division - immunology Chemokines Diabetes Diabetes. Impaired glucose tolerance Diabetic Nephropathies - complications Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology Diabetic nephropathy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Genotype Human Physiology Hyperglycemia Inflammation Inflammation - prevention & control Internal Medicine Kidney Tubules - immunology Kidney Tubules - pathology Kidneys Kinases Laboratories Leptin - genetics Ligands Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Mice, Obese Monoclonal antibodies Nephrology. Urinary tract diseases Obesity Obesity - complications Obesity - pathology Obesity - physiopathology Polymerase Chain Reaction Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors Receptor, Macrophage Colony-Stimulating Factor - immunology Transcription factors Urinary system involvement in other diseases. Miscellaneous
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