Lipopolysaccharide-induced inflammatory cytokine production by Schwann's cells dependent upon TLR4 expression

Abstract Signaling of Toll-like receptor-4 (TLR4) through its cognate ligand endotoxin appears critical in tissue inflammation associated with bacterial infection. We found that anti-GM1 antibody (Ab) enhances TLR4 expression in Schwann's cells (SCs) in vivo and in vitro . The anti-GM1 Ab-treat...

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