Comparison of Electrodesiccation and Potassium‐Titanyl‐Phosphate Laser for Treatment of Dermatosis Papulosa Nigra
BACKGROUND There is a lack of randomized split‐face studies investigating treatments for dermatosis papulosa nigra (DPN) in dark skin. OBJECTIVE To compare the efficacy, safety, and tolerability of potassium‐titanyl‐phosphate (KTP) laser with efficacy, safety, and tolerability of electrodesiccation...
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| Veröffentlicht in: | Dermatologic surgery 2009-07, Vol.35 (7), p.1079-1083 |
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| creator | KUNDU, ROOPAL V. JOSHI, SMITA S. SUH, KI‐YOUNG BOONE, SUSAN L. HUGGINS, RICHARD H. ALAM, MURAD WHITE, LUCILE RADEMAKER, ALFRED W. WEST, DENNIS P. YOO, SIMON |
| description | BACKGROUND
There is a lack of randomized split‐face studies investigating treatments for dermatosis papulosa nigra (DPN) in dark skin.
OBJECTIVE
To compare the efficacy, safety, and tolerability of potassium‐titanyl‐phosphate (KTP) laser with efficacy, safety, and tolerability of electrodesiccation in the treatment of DPN in subjects with Fitzpatrick skin phototypes IV to VI.
METHODS
Fourteen subjects with Fitzpatrick skin phototypes IV to VI were randomized to receive two KTP laser treatments 4 weeks apart to half of the face. The contralateral half received two electrodesiccation treatments 4 weeks apart. Response was evaluated by photography reviewed by blinded dermatologists at 4 weeks after the second treatment. A treatment quality questionnaire about side effects and cosmetic outcome was also administered.
RESULTS
Difference in improvement of DPN between the KTP side and the electrodesiccation side per each rater (p=.99, p=.54) and per raters combined (p=.50) did not reach statistical significance. There was no treatment difference for subjective effectiveness (p=.06) or subjective confidence improvement (p=.99), although there was a significant treatment difference for subjective discomfort (p=.002) in favor of KTP. Both treatments were well tolerated without significant adverse effects.
CONCLUSIONS
Although treatment of DPN with KTP laser and electrodesiccation are comparable in efficacy, KTP laser is preferable for patient comfort. |
| doi_str_mv | 10.1111/j.1524-4725.2009.01186.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67480349</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67480349</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5089-5ff9a042bda237e5ae6934a141f2e085da1d99165b9c591e9d5f9a877dad42423</originalsourceid><addsrcrecordid>eNqNkM2O0zAUhSMEYoaBV0DZwC7Bduw4XrBAneFHqqASnbV1m9xQFycutqOZ7ngEnpEnwaHRsMWS5WP7O_denSzLKSlpWm8OJRWMF1wyUTJCVEkobery_lF2-fDxOGki64IIyi6yZyEcCKFMVeRpdkEVr5VUzWU2rdxwBG-CG3PX5zcW2-hdh8G0LUSTXmHs8o2LEIKZht8_f21NhPFkk9rsXTjuIWK-hoA-753Ptx4hDjjGudo1-gGiCybkGzhO1gXIP5tvHp5nT3qwAV8s51V2-_5mu_pYrL98-LR6ty5aQRpViL5XQDjbdcAqiQKwVhUHymnPkDSiA9opRWuxU61QFFUnkqGRsoOOM86qq-z1ue7Rux8ThqgHE1q0FkZ0U9C15A2puEpgcwZb70Lw2OujNwP4k6ZEz5Hrg56T1XOyeo5c_41c3yfry6XHtBuw-2dcMk7AqwWA0ILtPYytCQ8co5JVjPDE8TN352xEH77b6Q693iPYuNeEpCAka4q5OZHpWqRN5tHfLjZj8fTfc-vrr7ezqv4A0sewBw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67480349</pqid></control><display><type>article</type><title>Comparison of Electrodesiccation and Potassium‐Titanyl‐Phosphate Laser for Treatment of Dermatosis Papulosa Nigra</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Complete</source><creator>KUNDU, ROOPAL V. ; JOSHI, SMITA S. ; SUH, KI‐YOUNG ; BOONE, SUSAN L. ; HUGGINS, RICHARD H. ; ALAM, MURAD ; WHITE, LUCILE ; RADEMAKER, ALFRED W. ; WEST, DENNIS P. ; YOO, SIMON</creator><creatorcontrib>KUNDU, ROOPAL V. ; JOSHI, SMITA S. ; SUH, KI‐YOUNG ; BOONE, SUSAN L. ; HUGGINS, RICHARD H. ; ALAM, MURAD ; WHITE, LUCILE ; RADEMAKER, ALFRED W. ; WEST, DENNIS P. ; YOO, SIMON</creatorcontrib><description>BACKGROUND
There is a lack of randomized split‐face studies investigating treatments for dermatosis papulosa nigra (DPN) in dark skin.
OBJECTIVE
To compare the efficacy, safety, and tolerability of potassium‐titanyl‐phosphate (KTP) laser with efficacy, safety, and tolerability of electrodesiccation in the treatment of DPN in subjects with Fitzpatrick skin phototypes IV to VI.
METHODS
Fourteen subjects with Fitzpatrick skin phototypes IV to VI were randomized to receive two KTP laser treatments 4 weeks apart to half of the face. The contralateral half received two electrodesiccation treatments 4 weeks apart. Response was evaluated by photography reviewed by blinded dermatologists at 4 weeks after the second treatment. A treatment quality questionnaire about side effects and cosmetic outcome was also administered.
RESULTS
Difference in improvement of DPN between the KTP side and the electrodesiccation side per each rater (p=.99, p=.54) and per raters combined (p=.50) did not reach statistical significance. There was no treatment difference for subjective effectiveness (p=.06) or subjective confidence improvement (p=.99), although there was a significant treatment difference for subjective discomfort (p=.002) in favor of KTP. Both treatments were well tolerated without significant adverse effects.
CONCLUSIONS
Although treatment of DPN with KTP laser and electrodesiccation are comparable in efficacy, KTP laser is preferable for patient comfort.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1111/j.1524-4725.2009.01186.x</identifier><identifier>PMID: 19469798</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adult ; Biological and medical sciences ; Dermatology ; Electrocoagulation ; Facial Dermatoses - radiotherapy ; Facial Dermatoses - surgery ; Female ; Humans ; Lasers, Solid-State - therapeutic use ; Low-Level Light Therapy ; Male ; Medical sciences ; Middle Aged ; Photography ; Prospective Studies ; Single-Blind Method ; Skin Pigmentation ; Skin plastic surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surveys and Questionnaires ; Treatment Outcome</subject><ispartof>Dermatologic surgery, 2009-07, Vol.35 (7), p.1079-1083</ispartof><rights>2009 by the American Society for Dermatologic Surgery, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5089-5ff9a042bda237e5ae6934a141f2e085da1d99165b9c591e9d5f9a877dad42423</citedby><cites>FETCH-LOGICAL-c5089-5ff9a042bda237e5ae6934a141f2e085da1d99165b9c591e9d5f9a877dad42423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1524-4725.2009.01186.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1524-4725.2009.01186.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21723204$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19469798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUNDU, ROOPAL V.</creatorcontrib><creatorcontrib>JOSHI, SMITA S.</creatorcontrib><creatorcontrib>SUH, KI‐YOUNG</creatorcontrib><creatorcontrib>BOONE, SUSAN L.</creatorcontrib><creatorcontrib>HUGGINS, RICHARD H.</creatorcontrib><creatorcontrib>ALAM, MURAD</creatorcontrib><creatorcontrib>WHITE, LUCILE</creatorcontrib><creatorcontrib>RADEMAKER, ALFRED W.</creatorcontrib><creatorcontrib>WEST, DENNIS P.</creatorcontrib><creatorcontrib>YOO, SIMON</creatorcontrib><title>Comparison of Electrodesiccation and Potassium‐Titanyl‐Phosphate Laser for Treatment of Dermatosis Papulosa Nigra</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>BACKGROUND
There is a lack of randomized split‐face studies investigating treatments for dermatosis papulosa nigra (DPN) in dark skin.
OBJECTIVE
To compare the efficacy, safety, and tolerability of potassium‐titanyl‐phosphate (KTP) laser with efficacy, safety, and tolerability of electrodesiccation in the treatment of DPN in subjects with Fitzpatrick skin phototypes IV to VI.
METHODS
Fourteen subjects with Fitzpatrick skin phototypes IV to VI were randomized to receive two KTP laser treatments 4 weeks apart to half of the face. The contralateral half received two electrodesiccation treatments 4 weeks apart. Response was evaluated by photography reviewed by blinded dermatologists at 4 weeks after the second treatment. A treatment quality questionnaire about side effects and cosmetic outcome was also administered.
RESULTS
Difference in improvement of DPN between the KTP side and the electrodesiccation side per each rater (p=.99, p=.54) and per raters combined (p=.50) did not reach statistical significance. There was no treatment difference for subjective effectiveness (p=.06) or subjective confidence improvement (p=.99), although there was a significant treatment difference for subjective discomfort (p=.002) in favor of KTP. Both treatments were well tolerated without significant adverse effects.
CONCLUSIONS
Although treatment of DPN with KTP laser and electrodesiccation are comparable in efficacy, KTP laser is preferable for patient comfort.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Electrocoagulation</subject><subject>Facial Dermatoses - radiotherapy</subject><subject>Facial Dermatoses - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Lasers, Solid-State - therapeutic use</subject><subject>Low-Level Light Therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Photography</subject><subject>Prospective Studies</subject><subject>Single-Blind Method</subject><subject>Skin Pigmentation</subject><subject>Skin plastic surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM2O0zAUhSMEYoaBV0DZwC7Bduw4XrBAneFHqqASnbV1m9xQFycutqOZ7ngEnpEnwaHRsMWS5WP7O_denSzLKSlpWm8OJRWMF1wyUTJCVEkobery_lF2-fDxOGki64IIyi6yZyEcCKFMVeRpdkEVr5VUzWU2rdxwBG-CG3PX5zcW2-hdh8G0LUSTXmHs8o2LEIKZht8_f21NhPFkk9rsXTjuIWK-hoA-753Ptx4hDjjGudo1-gGiCybkGzhO1gXIP5tvHp5nT3qwAV8s51V2-_5mu_pYrL98-LR6ty5aQRpViL5XQDjbdcAqiQKwVhUHymnPkDSiA9opRWuxU61QFFUnkqGRsoOOM86qq-z1ue7Rux8ThqgHE1q0FkZ0U9C15A2puEpgcwZb70Lw2OujNwP4k6ZEz5Hrg56T1XOyeo5c_41c3yfry6XHtBuw-2dcMk7AqwWA0ILtPYytCQ8co5JVjPDE8TN352xEH77b6Q693iPYuNeEpCAka4q5OZHpWqRN5tHfLjZj8fTfc-vrr7ezqv4A0sewBw</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>KUNDU, ROOPAL V.</creator><creator>JOSHI, SMITA S.</creator><creator>SUH, KI‐YOUNG</creator><creator>BOONE, SUSAN L.</creator><creator>HUGGINS, RICHARD H.</creator><creator>ALAM, MURAD</creator><creator>WHITE, LUCILE</creator><creator>RADEMAKER, ALFRED W.</creator><creator>WEST, DENNIS P.</creator><creator>YOO, SIMON</creator><general>Blackwell Publishing Inc</general><general>by the American Society for Dermatologic Surgery, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200907</creationdate><title>Comparison of Electrodesiccation and Potassium‐Titanyl‐Phosphate Laser for Treatment of Dermatosis Papulosa Nigra</title><author>KUNDU, ROOPAL V. ; JOSHI, SMITA S. ; SUH, KI‐YOUNG ; BOONE, SUSAN L. ; HUGGINS, RICHARD H. ; ALAM, MURAD ; WHITE, LUCILE ; RADEMAKER, ALFRED W. ; WEST, DENNIS P. ; YOO, SIMON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5089-5ff9a042bda237e5ae6934a141f2e085da1d99165b9c591e9d5f9a877dad42423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Electrocoagulation</topic><topic>Facial Dermatoses - radiotherapy</topic><topic>Facial Dermatoses - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Lasers, Solid-State - therapeutic use</topic><topic>Low-Level Light Therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Photography</topic><topic>Prospective Studies</topic><topic>Single-Blind Method</topic><topic>Skin Pigmentation</topic><topic>Skin plastic surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surveys and Questionnaires</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUNDU, ROOPAL V.</creatorcontrib><creatorcontrib>JOSHI, SMITA S.</creatorcontrib><creatorcontrib>SUH, KI‐YOUNG</creatorcontrib><creatorcontrib>BOONE, SUSAN L.</creatorcontrib><creatorcontrib>HUGGINS, RICHARD H.</creatorcontrib><creatorcontrib>ALAM, MURAD</creatorcontrib><creatorcontrib>WHITE, LUCILE</creatorcontrib><creatorcontrib>RADEMAKER, ALFRED W.</creatorcontrib><creatorcontrib>WEST, DENNIS P.</creatorcontrib><creatorcontrib>YOO, SIMON</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUNDU, ROOPAL V.</au><au>JOSHI, SMITA S.</au><au>SUH, KI‐YOUNG</au><au>BOONE, SUSAN L.</au><au>HUGGINS, RICHARD H.</au><au>ALAM, MURAD</au><au>WHITE, LUCILE</au><au>RADEMAKER, ALFRED W.</au><au>WEST, DENNIS P.</au><au>YOO, SIMON</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Electrodesiccation and Potassium‐Titanyl‐Phosphate Laser for Treatment of Dermatosis Papulosa Nigra</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2009-07</date><risdate>2009</risdate><volume>35</volume><issue>7</issue><spage>1079</spage><epage>1083</epage><pages>1079-1083</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>BACKGROUND
There is a lack of randomized split‐face studies investigating treatments for dermatosis papulosa nigra (DPN) in dark skin.
OBJECTIVE
To compare the efficacy, safety, and tolerability of potassium‐titanyl‐phosphate (KTP) laser with efficacy, safety, and tolerability of electrodesiccation in the treatment of DPN in subjects with Fitzpatrick skin phototypes IV to VI.
METHODS
Fourteen subjects with Fitzpatrick skin phototypes IV to VI were randomized to receive two KTP laser treatments 4 weeks apart to half of the face. The contralateral half received two electrodesiccation treatments 4 weeks apart. Response was evaluated by photography reviewed by blinded dermatologists at 4 weeks after the second treatment. A treatment quality questionnaire about side effects and cosmetic outcome was also administered.
RESULTS
Difference in improvement of DPN between the KTP side and the electrodesiccation side per each rater (p=.99, p=.54) and per raters combined (p=.50) did not reach statistical significance. There was no treatment difference for subjective effectiveness (p=.06) or subjective confidence improvement (p=.99), although there was a significant treatment difference for subjective discomfort (p=.002) in favor of KTP. Both treatments were well tolerated without significant adverse effects.
CONCLUSIONS
Although treatment of DPN with KTP laser and electrodesiccation are comparable in efficacy, KTP laser is preferable for patient comfort.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>19469798</pmid><doi>10.1111/j.1524-4725.2009.01186.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Dermatologic surgery, 2009-07, Vol.35 (7), p.1079-1083 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Dermatology Electrocoagulation Facial Dermatoses - radiotherapy Facial Dermatoses - surgery Female Humans Lasers, Solid-State - therapeutic use Low-Level Light Therapy Male Medical sciences Middle Aged Photography Prospective Studies Single-Blind Method Skin Pigmentation Skin plastic surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surveys and Questionnaires Treatment Outcome |
| title | Comparison of Electrodesiccation and Potassium‐Titanyl‐Phosphate Laser for Treatment of Dermatosis Papulosa Nigra |
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