CTL quality and the control of human retroviral infections

The CTL response plays a central part in deciding the outcome of viral infections. Evidence from host and viral genetics, gene expression microarrays and assays of T-cell phenotype and function indicate that individual differences in the efficiency of the virus-specific CTL response strongly determi...

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Veröffentlicht in:	European journal of immunology 2009-07, Vol.39 (7), p.1700-1712
1. Verfasser:	Bangham, Charles R.M
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology CTL efficiency Cytotoxicity, Immunologic - immunology Functional avidity Genes, MHC Class I - genetics Genotype HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV‐1 HTLV-I Infections - genetics HTLV-I Infections - immunology HTLV-I Infections - virology HTLV‐1 Human immunodeficiency virus 1 Human T-lymphotropic virus 1 Humans Polyfunctionality Retroviridae Infections - genetics Retroviridae Infections - immunology Retroviridae Infections - virology Retrovirus T-Lymphocytes, Cytotoxic - immunology
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