Role of GABA A receptors in the retrorubral field and ventral pallidum in rat jaw movements elicited by dopaminergic stimulation of the nucleus accumbens shell
The role of γ-aminobutyric acid (GABA) A receptors in the retrorubral field in the production of rat repetitive jaw movements was examined, as this nucleus receives a GABAergic, inhibitory input from the nucleus accumbens and is connected with the parvicellular reticular formation, a region that is...
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| Veröffentlicht in: | European journal of pharmacology 2005-03, Vol.510 (1), p.39-47 |
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| creator | Uchida, Takuya Adachi, Kazunori Fujita, Satoshi Lee, Jun Gionhaku, Nobuhito Cools, Alexander R. Koshikawa, Noriaki |
| description | The role of γ-aminobutyric acid (GABA)
A receptors in the retrorubral field in the production of rat repetitive jaw movements was examined, as this nucleus receives a GABAergic, inhibitory input from the nucleus accumbens and is connected with the parvicellular reticular formation, a region that is directly connected with the orofacial motor nuclei. The GABA
A receptor antagonist bicuculline (150 ng/0.2 μl per side) significantly produced repetitive jaw movements when injected bilaterally into the retrorubral field, but not the ventral pallidum. The effects of bicuculline were GABA
A receptor specific, because the effects were abolished by muscimol, a GABA
A receptor agonist, given into the same site. The bicuculline-induced jaw movements differed qualitatively from those elicited by injection of a mixture of (±)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1
H-3-benzazepine-7,8-diol (SKF 82958; 5 μg) and quinpirole (10 μg), agonist at dopamine D1 and D2 receptors respectively, into the nucleus accumbens shell. Nevertheless, bilateral injections of muscimol (10 ng, 25 ng and 50 ng/0.2 μl per side) into the retrorubral field significantly inhibited jaw movements evoked by the dopamine D1/D2 receptor stimulation in the nucleus accumbens shell. Bilateral injections of bicuculline (50 ng and 150 ng/0.2 μl per side) also reduced the dopamine D1/D2 receptor-mediated jaw movements. Essentially similar effects were obtained when muscimol and bicuculline were given into the ventral pallidum, a region that is also known to receive GABAergic inhibitory inputs from the nucleus accumbens. In conclusion, GABA
A receptor blockade in the retrorubral field elicits characteristic repetitive jaw movements, and the GABA
A receptors in that region as well as in the ventral pallidum modulate the accumbens-specific, dopamine D1/D2 receptor-mediated jaw movements. |
| doi_str_mv | 10.1016/j.ejphar.2005.01.012 |
| format | Article |
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A receptors in the retrorubral field in the production of rat repetitive jaw movements was examined, as this nucleus receives a GABAergic, inhibitory input from the nucleus accumbens and is connected with the parvicellular reticular formation, a region that is directly connected with the orofacial motor nuclei. The GABA
A receptor antagonist bicuculline (150 ng/0.2 μl per side) significantly produced repetitive jaw movements when injected bilaterally into the retrorubral field, but not the ventral pallidum. The effects of bicuculline were GABA
A receptor specific, because the effects were abolished by muscimol, a GABA
A receptor agonist, given into the same site. The bicuculline-induced jaw movements differed qualitatively from those elicited by injection of a mixture of (±)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1
H-3-benzazepine-7,8-diol (SKF 82958; 5 μg) and quinpirole (10 μg), agonist at dopamine D1 and D2 receptors respectively, into the nucleus accumbens shell. Nevertheless, bilateral injections of muscimol (10 ng, 25 ng and 50 ng/0.2 μl per side) into the retrorubral field significantly inhibited jaw movements evoked by the dopamine D1/D2 receptor stimulation in the nucleus accumbens shell. Bilateral injections of bicuculline (50 ng and 150 ng/0.2 μl per side) also reduced the dopamine D1/D2 receptor-mediated jaw movements. Essentially similar effects were obtained when muscimol and bicuculline were given into the ventral pallidum, a region that is also known to receive GABAergic inhibitory inputs from the nucleus accumbens. In conclusion, GABA
A receptor blockade in the retrorubral field elicits characteristic repetitive jaw movements, and the GABA
A receptors in that region as well as in the ventral pallidum modulate the accumbens-specific, dopamine D1/D2 receptor-mediated jaw movements.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2005.01.012</identifier><identifier>PMID: 15740723</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Benzazepines - pharmacology ; Bicuculline - pharmacology ; Dopamine Agents - pharmacology ; Dopamine Agonists - pharmacology ; Dopamine D1/D2 receptor stimulation ; GABA A receptor ; GABA Agonists - pharmacology ; GABA Antagonists - pharmacology ; GABA-A Receptor Agonists ; GABA-A Receptor Antagonists ; Globus Pallidus - physiology ; Jaw - drug effects ; Jaw - physiology ; Jaw movement ; Male ; Muscimol - pharmacology ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - physiology ; Nucleus accumbens shell ; Quinpirole - pharmacology ; Rat ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A - physiology ; Red Nucleus - physiology ; Retrorubral field ; Time Factors ; Ventral pallidum</subject><ispartof>European journal of pharmacology, 2005-03, Vol.510 (1), p.39-47</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2005.01.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15740723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uchida, Takuya</creatorcontrib><creatorcontrib>Adachi, Kazunori</creatorcontrib><creatorcontrib>Fujita, Satoshi</creatorcontrib><creatorcontrib>Lee, Jun</creatorcontrib><creatorcontrib>Gionhaku, Nobuhito</creatorcontrib><creatorcontrib>Cools, Alexander R.</creatorcontrib><creatorcontrib>Koshikawa, Noriaki</creatorcontrib><title>Role of GABA A receptors in the retrorubral field and ventral pallidum in rat jaw movements elicited by dopaminergic stimulation of the nucleus accumbens shell</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The role of γ-aminobutyric acid (GABA)
A receptors in the retrorubral field in the production of rat repetitive jaw movements was examined, as this nucleus receives a GABAergic, inhibitory input from the nucleus accumbens and is connected with the parvicellular reticular formation, a region that is directly connected with the orofacial motor nuclei. The GABA
A receptor antagonist bicuculline (150 ng/0.2 μl per side) significantly produced repetitive jaw movements when injected bilaterally into the retrorubral field, but not the ventral pallidum. The effects of bicuculline were GABA
A receptor specific, because the effects were abolished by muscimol, a GABA
A receptor agonist, given into the same site. The bicuculline-induced jaw movements differed qualitatively from those elicited by injection of a mixture of (±)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1
H-3-benzazepine-7,8-diol (SKF 82958; 5 μg) and quinpirole (10 μg), agonist at dopamine D1 and D2 receptors respectively, into the nucleus accumbens shell. Nevertheless, bilateral injections of muscimol (10 ng, 25 ng and 50 ng/0.2 μl per side) into the retrorubral field significantly inhibited jaw movements evoked by the dopamine D1/D2 receptor stimulation in the nucleus accumbens shell. Bilateral injections of bicuculline (50 ng and 150 ng/0.2 μl per side) also reduced the dopamine D1/D2 receptor-mediated jaw movements. Essentially similar effects were obtained when muscimol and bicuculline were given into the ventral pallidum, a region that is also known to receive GABAergic inhibitory inputs from the nucleus accumbens. In conclusion, GABA
A receptor blockade in the retrorubral field elicits characteristic repetitive jaw movements, and the GABA
A receptors in that region as well as in the ventral pallidum modulate the accumbens-specific, dopamine D1/D2 receptor-mediated jaw movements.</description><subject>Animals</subject><subject>Benzazepines - pharmacology</subject><subject>Bicuculline - pharmacology</subject><subject>Dopamine Agents - pharmacology</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Dopamine D1/D2 receptor stimulation</subject><subject>GABA A receptor</subject><subject>GABA Agonists - pharmacology</subject><subject>GABA Antagonists - pharmacology</subject><subject>GABA-A Receptor Agonists</subject><subject>GABA-A Receptor Antagonists</subject><subject>Globus Pallidus - physiology</subject><subject>Jaw - drug effects</subject><subject>Jaw - physiology</subject><subject>Jaw movement</subject><subject>Male</subject><subject>Muscimol - pharmacology</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - physiology</subject><subject>Nucleus accumbens shell</subject><subject>Quinpirole - pharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, GABA-A - physiology</subject><subject>Red Nucleus - physiology</subject><subject>Retrorubral field</subject><subject>Time Factors</subject><subject>Ventral pallidum</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kd1q3DAQhUVpSDZp3qAUXfXOW0n-kXVT2IY2KQQCpb0WsjTuysiSK8kb8jR91cpsCgMDZz7mDHMQek_JnhLafZr2MC1HFfeMkHZPaCn2Bu1oz0VFOGVv0Y4Q2lRMCHGFrlOaSAEFay_RFW15Qzird-jvj-AAhxHfH74c8AFH0LDkEBO2HucjFCHHENchKodHC85g5Q0-gc-bsijnrFnnjY4q40k94zmcYC7zhMFZbTMYPLxgExY1Ww_xt9U4ZTuvTmUb_Oa9-fhVO1gTVlqv8wA-4XQE596hi1G5BLev_Qb9-vb1591D9fh0__3u8FgBFU2u2GBG0_ddC11nSK2oqPt67FkLqqNj07ZCE6JF14xDQzrDa8Z522pmegKmFrS-QR_Pe5cY_qyQspxt0uUA5SGsSXa84YI3rIAfXsF1mMHIJdpZxRf5_6UF-HwGoJx7shBl0ha8BmPLc7M0wUpK5JahnOQ5Q7llKAktxep_inaR5w</recordid><startdate>20050307</startdate><enddate>20050307</enddate><creator>Uchida, Takuya</creator><creator>Adachi, Kazunori</creator><creator>Fujita, Satoshi</creator><creator>Lee, Jun</creator><creator>Gionhaku, Nobuhito</creator><creator>Cools, Alexander R.</creator><creator>Koshikawa, Noriaki</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050307</creationdate><title>Role of GABA A receptors in the retrorubral field and ventral pallidum in rat jaw movements elicited by dopaminergic stimulation of the nucleus accumbens shell</title><author>Uchida, Takuya ; Adachi, Kazunori ; Fujita, Satoshi ; Lee, Jun ; Gionhaku, Nobuhito ; Cools, Alexander R. ; Koshikawa, Noriaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e194t-2bdfd8865e66d03a19383f825ea61f4559c00c964fb406d7327755c2d80ed3913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Benzazepines - pharmacology</topic><topic>Bicuculline - pharmacology</topic><topic>Dopamine Agents - pharmacology</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Dopamine D1/D2 receptor stimulation</topic><topic>GABA A receptor</topic><topic>GABA Agonists - pharmacology</topic><topic>GABA Antagonists - pharmacology</topic><topic>GABA-A Receptor Agonists</topic><topic>GABA-A Receptor Antagonists</topic><topic>Globus Pallidus - physiology</topic><topic>Jaw - drug effects</topic><topic>Jaw - physiology</topic><topic>Jaw movement</topic><topic>Male</topic><topic>Muscimol - pharmacology</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - physiology</topic><topic>Nucleus accumbens shell</topic><topic>Quinpirole - pharmacology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, GABA-A - physiology</topic><topic>Red Nucleus - physiology</topic><topic>Retrorubral field</topic><topic>Time Factors</topic><topic>Ventral pallidum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uchida, Takuya</creatorcontrib><creatorcontrib>Adachi, Kazunori</creatorcontrib><creatorcontrib>Fujita, Satoshi</creatorcontrib><creatorcontrib>Lee, Jun</creatorcontrib><creatorcontrib>Gionhaku, Nobuhito</creatorcontrib><creatorcontrib>Cools, Alexander R.</creatorcontrib><creatorcontrib>Koshikawa, Noriaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uchida, Takuya</au><au>Adachi, Kazunori</au><au>Fujita, Satoshi</au><au>Lee, Jun</au><au>Gionhaku, Nobuhito</au><au>Cools, Alexander R.</au><au>Koshikawa, Noriaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of GABA A receptors in the retrorubral field and ventral pallidum in rat jaw movements elicited by dopaminergic stimulation of the nucleus accumbens shell</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2005-03-07</date><risdate>2005</risdate><volume>510</volume><issue>1</issue><spage>39</spage><epage>47</epage><pages>39-47</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>The role of γ-aminobutyric acid (GABA)
A receptors in the retrorubral field in the production of rat repetitive jaw movements was examined, as this nucleus receives a GABAergic, inhibitory input from the nucleus accumbens and is connected with the parvicellular reticular formation, a region that is directly connected with the orofacial motor nuclei. The GABA
A receptor antagonist bicuculline (150 ng/0.2 μl per side) significantly produced repetitive jaw movements when injected bilaterally into the retrorubral field, but not the ventral pallidum. The effects of bicuculline were GABA
A receptor specific, because the effects were abolished by muscimol, a GABA
A receptor agonist, given into the same site. The bicuculline-induced jaw movements differed qualitatively from those elicited by injection of a mixture of (±)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1
H-3-benzazepine-7,8-diol (SKF 82958; 5 μg) and quinpirole (10 μg), agonist at dopamine D1 and D2 receptors respectively, into the nucleus accumbens shell. Nevertheless, bilateral injections of muscimol (10 ng, 25 ng and 50 ng/0.2 μl per side) into the retrorubral field significantly inhibited jaw movements evoked by the dopamine D1/D2 receptor stimulation in the nucleus accumbens shell. Bilateral injections of bicuculline (50 ng and 150 ng/0.2 μl per side) also reduced the dopamine D1/D2 receptor-mediated jaw movements. Essentially similar effects were obtained when muscimol and bicuculline were given into the ventral pallidum, a region that is also known to receive GABAergic inhibitory inputs from the nucleus accumbens. In conclusion, GABA
A receptor blockade in the retrorubral field elicits characteristic repetitive jaw movements, and the GABA
A receptors in that region as well as in the ventral pallidum modulate the accumbens-specific, dopamine D1/D2 receptor-mediated jaw movements.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15740723</pmid><doi>10.1016/j.ejphar.2005.01.012</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Benzazepines - pharmacology Bicuculline - pharmacology Dopamine Agents - pharmacology Dopamine Agonists - pharmacology Dopamine D1/D2 receptor stimulation GABA A receptor GABA Agonists - pharmacology GABA Antagonists - pharmacology GABA-A Receptor Agonists GABA-A Receptor Antagonists Globus Pallidus - physiology Jaw - drug effects Jaw - physiology Jaw movement Male Muscimol - pharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Nucleus accumbens shell Quinpirole - pharmacology Rat Rats Rats, Sprague-Dawley Receptors, GABA-A - physiology Red Nucleus - physiology Retrorubral field Time Factors Ventral pallidum |
| title | Role of GABA A receptors in the retrorubral field and ventral pallidum in rat jaw movements elicited by dopaminergic stimulation of the nucleus accumbens shell |
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