Genome profiling of chondrosarcoma using oligonucleotide array-based comparative genomic hybridization
Abstract Chondrosarcomas of the bone are malignant hyaline cartilage-forming tumors with an annual incidence rate of 3.6% of all primary bone malignancies in the United States. Specimens of 25 chondrosarcomas (10 grade I, 9 grade II, 1 grade III, and 5 dedifferentiated) from 23 patients were collect...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 2009-07, Vol.192 (2), p.56-59 |
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| creator | Hameed, Meera Ulger, Celal Yasar, Duygu Limaye, Neha Kurvathi, Rohini Streck, Deanna Benevenia, Joseph Patterson, Francis Dermody, James J Toruner, Gokce A |
| description | Abstract Chondrosarcomas of the bone are malignant hyaline cartilage-forming tumors with an annual incidence rate of 3.6% of all primary bone malignancies in the United States. Specimens of 25 chondrosarcomas (10 grade I, 9 grade II, 1 grade III, and 5 dedifferentiated) from 23 patients were collected from the Department of Pathology at the University Hospital at UMDNJ-New Jersey Medical School from 1996 to 2007. Array-based comparative genomic hybridization (array-CGH) studies were performed on frozen tumor specimens. Recurrent deletions observed in at least in six tumors were 5q13.2, 5q14.2∼q21.3, 6q12∼q13, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There was a statistically significant association between high-grade tumor (grade III and dedifferentiated) and the recurrent genetic deletions at 5q14.2∼q21.3, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There is consistency between increased levels of aneuploidy and the progression of chondrosarcoma from lower to higher grades. |
| doi_str_mv | 10.1016/j.cancergencyto.2009.03.009 |
| format | Article |
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Specimens of 25 chondrosarcomas (10 grade I, 9 grade II, 1 grade III, and 5 dedifferentiated) from 23 patients were collected from the Department of Pathology at the University Hospital at UMDNJ-New Jersey Medical School from 1996 to 2007. Array-based comparative genomic hybridization (array-CGH) studies were performed on frozen tumor specimens. Recurrent deletions observed in at least in six tumors were 5q13.2, 5q14.2∼q21.3, 6q12∼q13, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There was a statistically significant association between high-grade tumor (grade III and dedifferentiated) and the recurrent genetic deletions at 5q14.2∼q21.3, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There is consistency between increased levels of aneuploidy and the progression of chondrosarcoma from lower to higher grades.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/j.cancergencyto.2009.03.009</identifier><identifier>PMID: 19596254</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aneuploidy ; Chondrosarcoma - genetics ; Chromosome Deletion ; Comparative Genomic Hybridization ; Female ; Genome, Human - genetics ; Hematology, Oncology and Palliative Medicine ; Humans ; Male ; Medical Education ; Middle Aged ; Oligonucleotide Array Sequence Analysis</subject><ispartof>Cancer genetics and cytogenetics, 2009-07, Vol.192 (2), p.56-59</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-90fbdbcb421a234b0847eb83678e96b9a8bfb631bf593a9ad9387dc8bcc2e463</citedby><cites>FETCH-LOGICAL-c533t-90fbdbcb421a234b0847eb83678e96b9a8bfb631bf593a9ad9387dc8bcc2e463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cancergencyto.2009.03.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19596254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hameed, Meera</creatorcontrib><creatorcontrib>Ulger, Celal</creatorcontrib><creatorcontrib>Yasar, Duygu</creatorcontrib><creatorcontrib>Limaye, Neha</creatorcontrib><creatorcontrib>Kurvathi, Rohini</creatorcontrib><creatorcontrib>Streck, Deanna</creatorcontrib><creatorcontrib>Benevenia, Joseph</creatorcontrib><creatorcontrib>Patterson, Francis</creatorcontrib><creatorcontrib>Dermody, James J</creatorcontrib><creatorcontrib>Toruner, Gokce A</creatorcontrib><title>Genome profiling of chondrosarcoma using oligonucleotide array-based comparative genomic hybridization</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Abstract Chondrosarcomas of the bone are malignant hyaline cartilage-forming tumors with an annual incidence rate of 3.6% of all primary bone malignancies in the United States. Specimens of 25 chondrosarcomas (10 grade I, 9 grade II, 1 grade III, and 5 dedifferentiated) from 23 patients were collected from the Department of Pathology at the University Hospital at UMDNJ-New Jersey Medical School from 1996 to 2007. Array-based comparative genomic hybridization (array-CGH) studies were performed on frozen tumor specimens. Recurrent deletions observed in at least in six tumors were 5q13.2, 5q14.2∼q21.3, 6q12∼q13, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There was a statistically significant association between high-grade tumor (grade III and dedifferentiated) and the recurrent genetic deletions at 5q14.2∼q21.3, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There is consistency between increased levels of aneuploidy and the progression of chondrosarcoma from lower to higher grades.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneuploidy</subject><subject>Chondrosarcoma - genetics</subject><subject>Chromosome Deletion</subject><subject>Comparative Genomic Hybridization</subject><subject>Female</subject><subject>Genome, Human - genetics</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Male</subject><subject>Medical Education</subject><subject>Middle Aged</subject><subject>Oligonucleotide Array Sequence Analysis</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl2L1TAQhoMo7nH1L0hB8K41X00TBEGWdRUWvHDvQz6mZ3Nsm2PSLnR_vanngOiNXg0Mz7zDvO8g9IbghmAi3h0aZyYHaQ-TW-fYUIxVg1lTyhO0I7JjNeeteIp2hW5rLrC8QC9yPmCMO6rEc3RBVKsEbfkO9TcwxRGqY4p9GMK0r2Jfufs4-RSzSS6Oplryr_4Q9nFa3ABxDh4qk5JZa2sy-KpgR5PMHB6g2m-CwVX3q03Bh8fSjdNL9Kw3Q4ZX53qJ7j5d3119rm-_3ny5-nhbu5axuVa4t946yykxlHGLJe_ASiY6CUpYZaTtrWDE9q1iRhmvmOy8k9Y5ClywS_T2JFvO-bFAnvUYsoNhMBPEJWvR8U61tPsnSDGRLW5pAd-fQFf8yAl6fUxhNGnVBOstDn3Qf8Shtzg0ZrqUMv36vGaxI_jfs2f_C3B9AqCY8hAg6exCEQIfErhZ-xj-c9GHv3RcCTM4M3yHFfIhLmkqvmuiM9VYf9s-Y3sMrDAmnBD2E4zuu84</recordid><startdate>20090715</startdate><enddate>20090715</enddate><creator>Hameed, Meera</creator><creator>Ulger, Celal</creator><creator>Yasar, Duygu</creator><creator>Limaye, Neha</creator><creator>Kurvathi, Rohini</creator><creator>Streck, Deanna</creator><creator>Benevenia, Joseph</creator><creator>Patterson, Francis</creator><creator>Dermody, James J</creator><creator>Toruner, Gokce A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090715</creationdate><title>Genome profiling of chondrosarcoma using oligonucleotide array-based comparative genomic hybridization</title><author>Hameed, Meera ; 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Specimens of 25 chondrosarcomas (10 grade I, 9 grade II, 1 grade III, and 5 dedifferentiated) from 23 patients were collected from the Department of Pathology at the University Hospital at UMDNJ-New Jersey Medical School from 1996 to 2007. Array-based comparative genomic hybridization (array-CGH) studies were performed on frozen tumor specimens. Recurrent deletions observed in at least in six tumors were 5q13.2, 5q14.2∼q21.3, 6q12∼q13, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There was a statistically significant association between high-grade tumor (grade III and dedifferentiated) and the recurrent genetic deletions at 5q14.2∼q21.3, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There is consistency between increased levels of aneuploidy and the progression of chondrosarcoma from lower to higher grades.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19596254</pmid><doi>10.1016/j.cancergencyto.2009.03.009</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aneuploidy Chondrosarcoma - genetics Chromosome Deletion Comparative Genomic Hybridization Female Genome, Human - genetics Hematology, Oncology and Palliative Medicine Humans Male Medical Education Middle Aged Oligonucleotide Array Sequence Analysis |
| title | Genome profiling of chondrosarcoma using oligonucleotide array-based comparative genomic hybridization |
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