Two spent dialysate samples are sufficient for hemodialysis efficacy assessment

The measure of dialysis efficacy is expressed as Kt/V value (calculated from predialysis and postdialysis blood urea concentration). The aim of this study was to assess the possibility of direct calculation of Kt/V value from two spent dialysate samples by using the regular blood-based Kt/V calculat...

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Veröffentlicht in:International journal of artificial organs 2005-01, Vol.28 (1), p.22-29
Hauptverfasser: Kovacic, V, Ljutic, D
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description The measure of dialysis efficacy is expressed as Kt/V value (calculated from predialysis and postdialysis blood urea concentration). The aim of this study was to assess the possibility of direct calculation of Kt/V value from two spent dialysate samples by using the regular blood-based Kt/V calculation formula with dialysate samples used as surrogates for blood samples, and to detect the most appropriate couple of dialysate samples for Kt/V estimation. Fifty-two single hemodialysis treatments in 34 anuric patients on chronic bicarbonate low-flux hemodialysis were observed. Kt/V values according to Daugirdas formula from two blood samples and from two dialysate samples were calculated. Kt/V values calculated according to Daugirdas 2 nd generation formula from blood samples (Kt/V sp Daugirdas) were in significant correlation with all Kt/V values obtained from two spent dialysate samples. The highest correlation coefficient (r = 0.74, p < 0.001) and the least standard error of mean of the differences were found between Kt/V sp Daugirdas and value obtained with substitution of urea concentration from dialysate samples taken 60 minutes after dialysis start and at the end of the dialysis into Daugirdas 2 nd generation formula (Kt/V D C D(60) -C D(e) ), which can be expressed as a equation of linear regression y = 0.47 + 0.86x. The highest correlation coefficient (r =0.74, p < 0.001) was found between Kt/V sp Daugirdas values equilibrated according to Daugirdas rate formula, and Kt/V D C D(60) -C D(e) value, which can also be expressed as an equation of linear regression y = 0.43 + 0.73x. The results of this study clearly show the sufficiency of only two spent dialysate samples for direct estimation of the Kt/V values, with no blood sample required.
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The aim of this study was to assess the possibility of direct calculation of Kt/V value from two spent dialysate samples by using the regular blood-based Kt/V calculation formula with dialysate samples used as surrogates for blood samples, and to detect the most appropriate couple of dialysate samples for Kt/V estimation. Fifty-two single hemodialysis treatments in 34 anuric patients on chronic bicarbonate low-flux hemodialysis were observed. Kt/V values according to Daugirdas formula from two blood samples and from two dialysate samples were calculated. Kt/V values calculated according to Daugirdas 2 nd generation formula from blood samples (Kt/V sp Daugirdas) were in significant correlation with all Kt/V values obtained from two spent dialysate samples. The highest correlation coefficient (r = 0.74, p &lt; 0.001) and the least standard error of mean of the differences were found between Kt/V sp Daugirdas and value obtained with substitution of urea concentration from dialysate samples taken 60 minutes after dialysis start and at the end of the dialysis into Daugirdas 2 nd generation formula (Kt/V D C D(60) -C D(e) ), which can be expressed as a equation of linear regression y = 0.47 + 0.86x. The highest correlation coefficient (r =0.74, p &lt; 0.001) was found between Kt/V sp Daugirdas values equilibrated according to Daugirdas rate formula, and Kt/V D C D(60) -C D(e) value, which can also be expressed as an equation of linear regression y = 0.43 + 0.73x. 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The aim of this study was to assess the possibility of direct calculation of Kt/V value from two spent dialysate samples by using the regular blood-based Kt/V calculation formula with dialysate samples used as surrogates for blood samples, and to detect the most appropriate couple of dialysate samples for Kt/V estimation. Fifty-two single hemodialysis treatments in 34 anuric patients on chronic bicarbonate low-flux hemodialysis were observed. Kt/V values according to Daugirdas formula from two blood samples and from two dialysate samples were calculated. Kt/V values calculated according to Daugirdas 2 nd generation formula from blood samples (Kt/V sp Daugirdas) were in significant correlation with all Kt/V values obtained from two spent dialysate samples. The highest correlation coefficient (r = 0.74, p &lt; 0.001) and the least standard error of mean of the differences were found between Kt/V sp Daugirdas and value obtained with substitution of urea concentration from dialysate samples taken 60 minutes after dialysis start and at the end of the dialysis into Daugirdas 2 nd generation formula (Kt/V D C D(60) -C D(e) ), which can be expressed as a equation of linear regression y = 0.47 + 0.86x. The highest correlation coefficient (r =0.74, p &lt; 0.001) was found between Kt/V sp Daugirdas values equilibrated according to Daugirdas rate formula, and Kt/V D C D(60) -C D(e) value, which can also be expressed as an equation of linear regression y = 0.43 + 0.73x. The results of this study clearly show the sufficiency of only two spent dialysate samples for direct estimation of the Kt/V values, with no blood sample required.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Algorithms</subject><subject>Body Weight</subject><subject>Dialysis Solutions - analysis</subject><subject>Female</subject><subject>Hemodiafiltration</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Renal Dialysis - methods</subject><subject>Renal Dialysis - standards</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Urea - analysis</subject><subject>Urea - blood</subject><issn>0391-3988</issn><issn>1724-6040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbK3-AQ-Sk7fo7Ed2s0cRv6DQSz2H6XYWI0kTMwnSf29CCx48eJqBed6X4RHiWsKdlM7dg_ZS-zyHDFQOICE7EXPplEktGDgV8wlIJ2ImLpg_R8Qak52LmcycURrsXKzW303CLe36ZFtitWfsKWGs24o4wW7chxjLUE5AbLrkg-rmAJac0HTCsE-QmZjrEboUZxErpqvjXIj356f142u6XL28PT4s06By3acBwRIaAG9klCq30fkMHOUbqaxHPz5uMNuYYJTE3CMQbJ2PECEYPZ70Qtweetuu-RqI-6IuOVBV4Y6agQvrjPNSyX9B6U1m9WhjIdQBDF3D3FEs2q6ssdsXEorJd_HX9xi6ObYPm5q2v5GjYP0DrlJ6SQ</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Kovacic, V</creator><creator>Ljutic, D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Two spent dialysate samples are sufficient for hemodialysis efficacy assessment</title><author>Kovacic, V ; Ljutic, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c283t-ca06ea400941f1286f79507e8b1269a93914a5b4c421a89a0e0d79f0f0c4314a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Body Weight</topic><topic>Dialysis Solutions - analysis</topic><topic>Female</topic><topic>Hemodiafiltration</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Renal Dialysis - methods</topic><topic>Renal Dialysis - standards</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Urea - analysis</topic><topic>Urea - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kovacic, V</creatorcontrib><creatorcontrib>Ljutic, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kovacic, V</au><au>Ljutic, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two spent dialysate samples are sufficient for hemodialysis efficacy assessment</atitle><jtitle>International journal of artificial organs</jtitle><addtitle>Int J Artif Organs</addtitle><date>2005-01</date><risdate>2005</risdate><volume>28</volume><issue>1</issue><spage>22</spage><epage>29</epage><pages>22-29</pages><issn>0391-3988</issn><eissn>1724-6040</eissn><abstract>The measure of dialysis efficacy is expressed as Kt/V value (calculated from predialysis and postdialysis blood urea concentration). The aim of this study was to assess the possibility of direct calculation of Kt/V value from two spent dialysate samples by using the regular blood-based Kt/V calculation formula with dialysate samples used as surrogates for blood samples, and to detect the most appropriate couple of dialysate samples for Kt/V estimation. Fifty-two single hemodialysis treatments in 34 anuric patients on chronic bicarbonate low-flux hemodialysis were observed. Kt/V values according to Daugirdas formula from two blood samples and from two dialysate samples were calculated. Kt/V values calculated according to Daugirdas 2 nd generation formula from blood samples (Kt/V sp Daugirdas) were in significant correlation with all Kt/V values obtained from two spent dialysate samples. The highest correlation coefficient (r = 0.74, p &lt; 0.001) and the least standard error of mean of the differences were found between Kt/V sp Daugirdas and value obtained with substitution of urea concentration from dialysate samples taken 60 minutes after dialysis start and at the end of the dialysis into Daugirdas 2 nd generation formula (Kt/V D C D(60) -C D(e) ), which can be expressed as a equation of linear regression y = 0.47 + 0.86x. The highest correlation coefficient (r =0.74, p &lt; 0.001) was found between Kt/V sp Daugirdas values equilibrated according to Daugirdas rate formula, and Kt/V D C D(60) -C D(e) value, which can also be expressed as an equation of linear regression y = 0.43 + 0.73x. The results of this study clearly show the sufficiency of only two spent dialysate samples for direct estimation of the Kt/V values, with no blood sample required.</abstract><cop>United States</cop><pmid>15742306</pmid><doi>10.1177/039139880502800105</doi><tpages>8</tpages></addata></record>
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subjects Adult
Age Factors
Aged
Algorithms
Body Weight
Dialysis Solutions - analysis
Female
Hemodiafiltration
Humans
Linear Models
Male
Middle Aged
Renal Dialysis - methods
Renal Dialysis - standards
Time Factors
Treatment Outcome
Urea - analysis
Urea - blood
title Two spent dialysate samples are sufficient for hemodialysis efficacy assessment
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