Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells

Abstract Resveratrol has both apoptosis and autophagy-promoting activities in different cancer cells. Dihydroceramide is the immediate precursor of the apoptotic mediator ceramide in the de novo sphingolipid synthesis pathway. Here we demonstrate that resveratrol induces autophagy in HGC-27 cells, w...

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Veröffentlicht in:	Cancer letters 2009-09, Vol.282 (2), p.238-243
Hauptverfasser:	Signorelli, Paola, Munoz-Olaya, Jose M, Gagliostro, Vincenzo, Casas, Josefina, Ghidoni, Riccardo, Fabriàs, Gemma
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Binding sites Breast cancer Cancer Cancer therapies Cell cycle Cell Line, Tumor Ceramides - analysis Ceramides - pharmacology Ceramides - physiology Desaturase Dihydroceramide Enzyme kinetics Gastric cancer Hematology, Oncology and Palliative Medicine Humans Oxidoreductases - antagonists & inhibitors Proteins Resveratrol Rodents Stilbenes - pharmacology Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology Sulfides - pharmacology
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