Synthesis, Biological Evaluation, and Molecular Modeling of Ribose-Modified Adenosine Analogues as Adenosine Receptor Agonists

A number of 3‘-C-methyl analogues of selective adenosine receptor agonists such as CPA, CHA, CCPA, 2‘-Me-CCPA, NECA, and IB-MECA was synthesized to further investigate the subdomain of the receptor that binds the ribose moiety of the ligands. Affinity data at A1, A2A, and A3 receptors in bovine brai...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-03, Vol.48 (5), p.1550-1562
Hauptverfasser:	Cappellacci, Loredana, Franchetti, Palmarisa, Pasqualini, Michela, Petrelli, Riccardo, Vita, Patrizia, Lavecchia, Antonio, Novellino, Ettore, Costa, Barbara, Martini, Claudia, Klotz, Karl-Norbert, Grifantini, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - chemical synthesis Adenosine - pharmacology Adenylyl Cyclase Inhibitors Animals Binding, Competitive Biological and medical sciences Brain - metabolism Cattle CHO Cells Cricetinae Cricetulus Humans In Vitro Techniques Medical sciences Miscellaneous Models, Molecular Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Purinergic P1 Receptor Agonists Radioligand Assay Rats Receptors, Purinergic P1 - chemistry Ribose - chemistry
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