Anaplastic Thyroid Carcinoma Exhibits Intratumoral Molecular Homogeneity for a Therapeutic Target Panel
Background: The objective of this work was to determine if molecular heterogeneity exists between different intratumoral histological subtype foci of anaplastic thyroid carcinoma (ATC). Materials and Methods: A tissue microarray composed of 12 ATC specimens from 6 patients (two discrete histological...
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| Veröffentlicht in: | Anticancer research 2009-07, Vol.29 (7), p.2437-2444 |
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| creator | DEEN, Shaun GRIFFITH, Obi L MASOUDI, Hamid GOWN, Allen JONES, Steven J. M WISEMAN, Sam M |
| description | Background: The objective of this work was to determine if molecular heterogeneity exists between different intratumoral histological
subtype foci of anaplastic thyroid carcinoma (ATC). Materials and Methods: A tissue microarray composed of 12 ATC specimens
from 6 patients (two discrete histological subtype foci from each tumor) were evaluated for expression of 51 different molecular
markers. Significant associations between marker staining and tumor focus (primary versus secondary) or subtype (epithelioid,
giant cell, or spindled) were determined using contingency table statistics and samples and markers were clustered using a
hierarchical clustering algorithm. Correlation between marker staining for the two tumor foci was also evaluated for each
patient using a Spearman correlation. Results: Significant correlations and clustering were observed for the overall staining
patterns for paired anaplastic foci from the same patient. This suggests that the different intratumoral foci showed consistent
or homogeneous staining. Conclusion: These results suggest that observed ATC phenotypic heterogeneity does not necessarily
reflect heterogeneity for therapeutic target expression. |
| format | Article |
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subtype foci of anaplastic thyroid carcinoma (ATC). Materials and Methods: A tissue microarray composed of 12 ATC specimens
from 6 patients (two discrete histological subtype foci from each tumor) were evaluated for expression of 51 different molecular
markers. Significant associations between marker staining and tumor focus (primary versus secondary) or subtype (epithelioid,
giant cell, or spindled) were determined using contingency table statistics and samples and markers were clustered using a
hierarchical clustering algorithm. Correlation between marker staining for the two tumor foci was also evaluated for each
patient using a Spearman correlation. Results: Significant correlations and clustering were observed for the overall staining
patterns for paired anaplastic foci from the same patient. This suggests that the different intratumoral foci showed consistent
or homogeneous staining. Conclusion: These results suggest that observed ATC phenotypic heterogeneity does not necessarily
reflect heterogeneity for therapeutic target expression.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 19596911</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Algorithms ; Biological and medical sciences ; Cohort Studies ; Endocrinopathies ; Humans ; Malignant tumors ; Medical sciences ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Thyroid. Thyroid axis (diseases) ; Tumors</subject><ispartof>Anticancer research, 2009-07, Vol.29 (7), p.2437-2444</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21713466$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19596911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DEEN, Shaun</creatorcontrib><creatorcontrib>GRIFFITH, Obi L</creatorcontrib><creatorcontrib>MASOUDI, Hamid</creatorcontrib><creatorcontrib>GOWN, Allen</creatorcontrib><creatorcontrib>JONES, Steven J. M</creatorcontrib><creatorcontrib>WISEMAN, Sam M</creatorcontrib><title>Anaplastic Thyroid Carcinoma Exhibits Intratumoral Molecular Homogeneity for a Therapeutic Target Panel</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: The objective of this work was to determine if molecular heterogeneity exists between different intratumoral histological
subtype foci of anaplastic thyroid carcinoma (ATC). Materials and Methods: A tissue microarray composed of 12 ATC specimens
from 6 patients (two discrete histological subtype foci from each tumor) were evaluated for expression of 51 different molecular
markers. Significant associations between marker staining and tumor focus (primary versus secondary) or subtype (epithelioid,
giant cell, or spindled) were determined using contingency table statistics and samples and markers were clustered using a
hierarchical clustering algorithm. Correlation between marker staining for the two tumor foci was also evaluated for each
patient using a Spearman correlation. Results: Significant correlations and clustering were observed for the overall staining
patterns for paired anaplastic foci from the same patient. This suggests that the different intratumoral foci showed consistent
or homogeneous staining. Conclusion: These results suggest that observed ATC phenotypic heterogeneity does not necessarily
reflect heterogeneity for therapeutic target expression.</description><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Endocrinopathies</subject><subject>Humans</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AURYMotlb_gsxGd4H5SGaSZSnVFiq6qOvwkrwkI5NMnUnQ_nsHrcqF9zaHw-WeRXOmcharVNDzaE55SmNFaTqLrrx_o1TKPBOX0YzlaS5zxuZRuxzgYMCPuiL77uisrskKXKUH2wNZf3a61KMn22F0ME69dWDIkzVYTQYc2djetjigHo-ksY5AcKCDA07fPnAtjuQFBjTX0UUDxuPN6S-i14f1frWJd8-P29VyF3dc5mPcVHXJWZ5IQVFxjlkDTHFWp1klUiHDFZgCTwQtJeU0SzBLSqgzLgBFE7KI7n-8B2ffJ_Rj0WtfoTGhhJ18IVWiFEt4AG9P4FT2WBcHp3twx-J3mgDcnQDwFZjGwVBp_8dxpphIpPznOt12H9ph4XswJmhFAY7nhSpCXyW-AJNqey8</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>DEEN, Shaun</creator><creator>GRIFFITH, Obi L</creator><creator>MASOUDI, Hamid</creator><creator>GOWN, Allen</creator><creator>JONES, Steven J. M</creator><creator>WISEMAN, Sam M</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Anaplastic Thyroid Carcinoma Exhibits Intratumoral Molecular Homogeneity for a Therapeutic Target Panel</title><author>DEEN, Shaun ; GRIFFITH, Obi L ; MASOUDI, Hamid ; GOWN, Allen ; JONES, Steven J. M ; WISEMAN, Sam M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-fcdb2194630e722e8fa1721d58c35368c33e5a2430b602084e84bad823ae3f3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Endocrinopathies</topic><topic>Humans</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEEN, Shaun</creatorcontrib><creatorcontrib>GRIFFITH, Obi L</creatorcontrib><creatorcontrib>MASOUDI, Hamid</creatorcontrib><creatorcontrib>GOWN, Allen</creatorcontrib><creatorcontrib>JONES, Steven J. M</creatorcontrib><creatorcontrib>WISEMAN, Sam M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DEEN, Shaun</au><au>GRIFFITH, Obi L</au><au>MASOUDI, Hamid</au><au>GOWN, Allen</au><au>JONES, Steven J. M</au><au>WISEMAN, Sam M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaplastic Thyroid Carcinoma Exhibits Intratumoral Molecular Homogeneity for a Therapeutic Target Panel</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>29</volume><issue>7</issue><spage>2437</spage><epage>2444</epage><pages>2437-2444</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: The objective of this work was to determine if molecular heterogeneity exists between different intratumoral histological
subtype foci of anaplastic thyroid carcinoma (ATC). Materials and Methods: A tissue microarray composed of 12 ATC specimens
from 6 patients (two discrete histological subtype foci from each tumor) were evaluated for expression of 51 different molecular
markers. Significant associations between marker staining and tumor focus (primary versus secondary) or subtype (epithelioid,
giant cell, or spindled) were determined using contingency table statistics and samples and markers were clustered using a
hierarchical clustering algorithm. Correlation between marker staining for the two tumor foci was also evaluated for each
patient using a Spearman correlation. Results: Significant correlations and clustering were observed for the overall staining
patterns for paired anaplastic foci from the same patient. This suggests that the different intratumoral foci showed consistent
or homogeneous staining. Conclusion: These results suggest that observed ATC phenotypic heterogeneity does not necessarily
reflect heterogeneity for therapeutic target expression.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>19596911</pmid><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Algorithms Biological and medical sciences Cohort Studies Endocrinopathies Humans Malignant tumors Medical sciences Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases) Tumors |
| title | Anaplastic Thyroid Carcinoma Exhibits Intratumoral Molecular Homogeneity for a Therapeutic Target Panel |
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