NMR studies reveal structural differences between the gallium and yttrium complexes of DOTA-D-Phe1-Tyr3-octreotide

The somatostatin analogue DOTATOC, DOTA-[Tyr(3)]octreotide, is used for in vivo diagnosis and targeted therapy of somatostatin-receptor-positive tumors. DOTATOC consists of a disulfide-bridged octapeptide, d-Phe(1)-Cys(2)-Tyr(3)-d-Trp(4)-Lys(5)-Thr(6)-Cys(7)-Thr(8)-ol, connected to the metal chelato...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-03, Vol.48 (5), p.1506-1514
Hauptverfasser:	DESHMUKH, Mandar V, VOLL, Georg, KÜHLEWEIN, Angelika, MÄCKE, Helmut, SCHMITT, Jörg, KESSLER, Horst, GEMMECKER, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry Coordination compounds Exact sciences and technology Gallium Inorganic chemistry and origins of life Magnetic Resonance Spectroscopy Medical sciences Miscellaneous Models, Molecular Molecular Conformation Molecular Structure Octreotide - analogs & derivatives Octreotide - chemistry Organometallic Compounds - chemistry Pharmacology. Drug treatments Preparations and properties Stereoisomerism Yttrium
Online-Zugang:	Volltext
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