Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures: A Universal Tool for Development of Aptamers

Aptamers are DNA (or RNA) ligands selected from large libraries of random DNA sequences and capable of binding different classes of targets with high affinity and selectivity. Both the chances for the aptamer to be selected and the quality of the selected aptamer are largely dependent on the method...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-03, Vol.127 (9), p.3165-3171
Hauptverfasser:	Berezovski, Maxim, Drabovich, Andrei, Krylova, Svetlana M, Musheev, Michael, Okhonin, Victor, Petrov, Alexander, Krylov, Sergey N
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases - chemistry Alkyl and Aryl Transferases - genetics Alkyl and Aryl Transferases - metabolism Analytical, structural and metabolic biochemistry Base Sequence Biological and medical sciences DNA - chemistry DNA - genetics DNA - metabolism Electrophoresis, Capillary - methods Farnesyltranstransferase Fundamental and applied biological sciences. Psychology Gene Library General aspects, investigation methods Kinetics Nucleic acids Oligonucleotides - chemistry RNA - chemistry
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