Quality by design approach to understand the process of nanosuspension preparation

Quality by design (QbD) principles were explored to maximize the understanding of the unit operation of microfluidization, for the preparation of nanosuspensions using indomethacin as a model drug. The effects of key formulation and process variables (drug concentration, stabilizer type, stabilizer...

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Veröffentlicht in:	International journal of pharmaceutics 2009-07, Vol.377 (1), p.185-198
Hauptverfasser:	Verma, Sudhir, Lan, Yan, Gokhale, Rajeev, Burgess, Diane J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry, Pharmaceutical - methods Drug Delivery Systems - methods Drug Stability Factorial design General pharmacology Indomethacin - administration & dosage Medical sciences Milling Nanoparticles - chemistry Nanosuspensions Nanotechnology - methods Optimization Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Quality by design Screening Technology, Pharmaceutical
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