Reaction Kinetics, Catalytic Mechanisms, Conformational Changes, and Inhibitor Design for Prenyltransferases

Isoprenoids comprise a family of more than 55000 natural products with great structural variety derived from five-carbon isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP). Allylic diphosphates such as farnesyl diphosphate (FPP) synthesized from DMAPP and IPP serve as out...

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Veröffentlicht in:	Biochemistry (Easton) 2009-07, Vol.48 (28), p.6562-6570
1. Verfasser:	Liang, Po-Huang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Dimethylallyltranstransferase - antagonists & inhibitors Dimethylallyltranstransferase - chemistry Dimethylallyltranstransferase - metabolism Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Kinetics Protein Conformation
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