A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols
This research investigates a promising antiviral compound based on polyprenols from Siberian silver fir (Abies sibirica). The physico-chemical characteristics of a preparation developed in aerosol form and an estimation of its protective efficacy against aerosol challenge of laboratory animals are p...
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| Veröffentlicht in: | Journal of aerosol medicine 2005-03, Vol.18 (1), p.55-62 |
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| creator | Safatov, A S Boldyrev, A N Bulychev, L E Buryak, G A Kukina, T P Poryvaev, V D P'yankov, O V Raldugin, V A Ryzhikov, A B Sergeev, A N Shishkina, L N Tolstikov, G A Zhukov, V A |
| description | This research investigates a promising antiviral compound based on polyprenols from Siberian silver fir (Abies sibirica). The physico-chemical characteristics of a preparation developed in aerosol form and an estimation of its protective efficacy against aerosol challenge of laboratory animals are presented. It is shown that (1) by using a simple ultrasonic disperser one can obtain aerosol of three formulations studied with about 70% of its mass accumulated in the size range below 1.8 microm; (2) 40-100% of aerosol particles contain preparation for different formulations; (3) after delivering under specified schedules, the preparations as developed can protect up to 100% of mice against 5 LD(50) of influenza A/Aichi/2/68 (H3N2) virus aerosol infection. Animals inhaled twice the preparation doses (which were 100 times lower than injection ones of the same efficacy) and did not exceed 10 microg/mouse. It was shown that the mode of action of this immunomodulating preparation was nonspecific stimulation of immune cells' various activities. |
| doi_str_mv | 10.1089/jam.2005.18.55 |
| format | Article |
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The physico-chemical characteristics of a preparation developed in aerosol form and an estimation of its protective efficacy against aerosol challenge of laboratory animals are presented. It is shown that (1) by using a simple ultrasonic disperser one can obtain aerosol of three formulations studied with about 70% of its mass accumulated in the size range below 1.8 microm; (2) 40-100% of aerosol particles contain preparation for different formulations; (3) after delivering under specified schedules, the preparations as developed can protect up to 100% of mice against 5 LD(50) of influenza A/Aichi/2/68 (H3N2) virus aerosol infection. Animals inhaled twice the preparation doses (which were 100 times lower than injection ones of the same efficacy) and did not exceed 10 microg/mouse. It was shown that the mode of action of this immunomodulating preparation was nonspecific stimulation of immune cells' various activities.</description><identifier>ISSN: 0894-2684</identifier><identifier>ISSN: 1941-2711</identifier><identifier>EISSN: 1557-9026</identifier><identifier>EISSN: 1941-2703</identifier><identifier>DOI: 10.1089/jam.2005.18.55</identifier><identifier>PMID: 15741774</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Abies ; Aerosols ; Animals ; Antiviral Agents - therapeutic use ; Female ; Health technology assessment ; Influenza A virus ; Male ; Mice ; Nebulizers and Vaporizers ; Orthomyxoviridae Infections - prevention & control ; Phytotherapy ; Plant Preparations</subject><ispartof>Journal of aerosol medicine, 2005-03, Vol.18 (1), p.55-62</ispartof><rights>(©) Copyright 2005, Mary Ann Liebert, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-a0e419131ceea9a8c42e490cd5057b1383c68dfaf051ed29a27fced5a7facc3d3</citedby><cites>FETCH-LOGICAL-c320t-a0e419131ceea9a8c42e490cd5057b1383c68dfaf051ed29a27fced5a7facc3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15741774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Safatov, A S</creatorcontrib><creatorcontrib>Boldyrev, A N</creatorcontrib><creatorcontrib>Bulychev, L E</creatorcontrib><creatorcontrib>Buryak, G A</creatorcontrib><creatorcontrib>Kukina, T P</creatorcontrib><creatorcontrib>Poryvaev, V D</creatorcontrib><creatorcontrib>P'yankov, O V</creatorcontrib><creatorcontrib>Raldugin, V A</creatorcontrib><creatorcontrib>Ryzhikov, A B</creatorcontrib><creatorcontrib>Sergeev, A N</creatorcontrib><creatorcontrib>Shishkina, L N</creatorcontrib><creatorcontrib>Tolstikov, G A</creatorcontrib><creatorcontrib>Zhukov, V A</creatorcontrib><title>A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols</title><title>Journal of aerosol medicine</title><addtitle>J Aerosol Med</addtitle><description>This research investigates a promising antiviral compound based on polyprenols from Siberian silver fir (Abies sibirica). The physico-chemical characteristics of a preparation developed in aerosol form and an estimation of its protective efficacy against aerosol challenge of laboratory animals are presented. It is shown that (1) by using a simple ultrasonic disperser one can obtain aerosol of three formulations studied with about 70% of its mass accumulated in the size range below 1.8 microm; (2) 40-100% of aerosol particles contain preparation for different formulations; (3) after delivering under specified schedules, the preparations as developed can protect up to 100% of mice against 5 LD(50) of influenza A/Aichi/2/68 (H3N2) virus aerosol infection. Animals inhaled twice the preparation doses (which were 100 times lower than injection ones of the same efficacy) and did not exceed 10 microg/mouse. It was shown that the mode of action of this immunomodulating preparation was nonspecific stimulation of immune cells' various activities.</description><subject>Abies</subject><subject>Aerosols</subject><subject>Animals</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Female</subject><subject>Health technology assessment</subject><subject>Influenza A virus</subject><subject>Male</subject><subject>Mice</subject><subject>Nebulizers and Vaporizers</subject><subject>Orthomyxoviridae Infections - prevention & control</subject><subject>Phytotherapy</subject><subject>Plant Preparations</subject><issn>0894-2684</issn><issn>1941-2711</issn><issn>1557-9026</issn><issn>1941-2703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkcGL1TAQxoMo7tvVq0cJHry1JmnSNMfHsurCghc9h2k6YfNok5q0h-dfbx77QPA0w8zvG2bmI-QDZy1ng_lygqUVjKmWD61Sr8iBK6Ubw0T_mhwqIBvRD_KG3JZyYoz1ctBvyQ1XWnKt5YHEI11z2tJ2XvGSrc_nGdwWHIW4hSZEP-8Y_0Dt4QoZtpAiDZEC5lTSTH3KC62l7RnpCCUUmjw9jgELLWEMObgqTfO5ymOayzvyxsNc8P013pFfXx9-3n9vnn58e7w_PjWuE2xrgKHkhnfcIYKBwUmB0jA3Kab0yLuhc_0wefBMcZyEAaG9w0mB9uBcN3V35PPL3HrS7x3LZpdQHM4zREx7sb2WWhnZV_DTf-Ap7TnW3azgphOmZxeofYFcPbpk9HbNYYF8tpzZiw222mAvNlg-WKWq4ON16j4uOP3Dr3_v_gLL_IX3</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Safatov, A S</creator><creator>Boldyrev, A N</creator><creator>Bulychev, L E</creator><creator>Buryak, G A</creator><creator>Kukina, T P</creator><creator>Poryvaev, V D</creator><creator>P'yankov, O V</creator><creator>Raldugin, V A</creator><creator>Ryzhikov, A B</creator><creator>Sergeev, A N</creator><creator>Shishkina, L N</creator><creator>Tolstikov, G A</creator><creator>Zhukov, V A</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols</title><author>Safatov, A S ; 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The physico-chemical characteristics of a preparation developed in aerosol form and an estimation of its protective efficacy against aerosol challenge of laboratory animals are presented. It is shown that (1) by using a simple ultrasonic disperser one can obtain aerosol of three formulations studied with about 70% of its mass accumulated in the size range below 1.8 microm; (2) 40-100% of aerosol particles contain preparation for different formulations; (3) after delivering under specified schedules, the preparations as developed can protect up to 100% of mice against 5 LD(50) of influenza A/Aichi/2/68 (H3N2) virus aerosol infection. Animals inhaled twice the preparation doses (which were 100 times lower than injection ones of the same efficacy) and did not exceed 10 microg/mouse. It was shown that the mode of action of this immunomodulating preparation was nonspecific stimulation of immune cells' various activities.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>15741774</pmid><doi>10.1089/jam.2005.18.55</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0894-2684 |
| ispartof | Journal of aerosol medicine, 2005-03, Vol.18 (1), p.55-62 |
| issn | 0894-2684 1941-2711 1557-9026 1941-2703 |
| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Abies Aerosols Animals Antiviral Agents - therapeutic use Female Health technology assessment Influenza A virus Male Mice Nebulizers and Vaporizers Orthomyxoviridae Infections - prevention & control Phytotherapy Plant Preparations |
| title | A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols |
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