Use of Follicle-Stimulating Hormone Test to Predict Poor Response in In Vitro Fertilization
OBJECTIVE:Optimized ovarian stimulation protocols are required for the success of in vitro fertilization (IVF). The purpose of this study was to estimate whether the ovarian reserve test using exogenous follicle-stimulating hormone (FSH) could predict ovarian response in IVF. METHODS:This was a pros...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2005-03, Vol.105 (3), p.645-652 |
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| creator | Iwase, Akira Ando, Hisao Kuno, Keiko Mizutani, Shigehiko |
| description | OBJECTIVE:Optimized ovarian stimulation protocols are required for the success of in vitro fertilization (IVF). The purpose of this study was to estimate whether the ovarian reserve test using exogenous follicle-stimulating hormone (FSH) could predict ovarian response in IVF.
METHODS:This was a prospective observational study of 110 patients who underwent their first IVF cycle. The FSH test was administered as 150 IU of urinary FSH daily from day 3 to day 6 of the menstrual cycle preceding the IVF cycle for evaluation of the plasma estradiol level. Outcomes of IVF, including ovarian response, were analyzed.
RESULTS:A negative correlation was observed between the duration of stimulation and the result of the FSH test (r = −.238, P = .014) and between the dose of FSH per retrieved mature oocyte (metaphase II oocyte) and the result of the FSH test (r = −.308, P < .001). In addition, our results showed that the result of the FSH test was significantly lower in poor responders defined by FSH of 400 IU/metaphase II oocyte or greater (207 ± 149 compared with 293 ± 174 pg/mL, P = .007).
CONCLUSION:The FSH test can be a useful tool for determining the conditions of individualized clinical management plans and optimizing stimulation protocols in IVF.
LEVEL OF EVIDENCE:II-2 |
| doi_str_mv | 10.1097/01.AOG.0000152334.23169.32 |
| format | Article |
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METHODS:This was a prospective observational study of 110 patients who underwent their first IVF cycle. The FSH test was administered as 150 IU of urinary FSH daily from day 3 to day 6 of the menstrual cycle preceding the IVF cycle for evaluation of the plasma estradiol level. Outcomes of IVF, including ovarian response, were analyzed.
RESULTS:A negative correlation was observed between the duration of stimulation and the result of the FSH test (r = −.238, P = .014) and between the dose of FSH per retrieved mature oocyte (metaphase II oocyte) and the result of the FSH test (r = −.308, P < .001). In addition, our results showed that the result of the FSH test was significantly lower in poor responders defined by FSH of 400 IU/metaphase II oocyte or greater (207 ± 149 compared with 293 ± 174 pg/mL, P = .007).
CONCLUSION:The FSH test can be a useful tool for determining the conditions of individualized clinical management plans and optimizing stimulation protocols in IVF.
LEVEL OF EVIDENCE:II-2</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/01.AOG.0000152334.23169.32</identifier><identifier>PMID: 15738039</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Biological and medical sciences ; Clomiphene - administration & dosage ; Estradiol - blood ; Female ; Fertility Agents, Female - administration & dosage ; Fertilization in Vitro ; Follicle Stimulating Hormone - blood ; Gynecology. Andrology. Obstetrics ; Humans ; Luteinizing Hormone - blood ; Medical sciences ; Menotropins - administration & dosage ; Oocytes ; Ovarian Function Tests ; Ovulation Induction ; Predictive Value of Tests ; Pregnancy ; Sensitivity and Specificity ; Sperm Injections, Intracytoplasmic</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2005-03, Vol.105 (3), p.645-652</ispartof><rights>2005 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3924-fe47aa446cd430092be403acc90bfb453530944cfe5d9ca31c3bec37b87d3f543</citedby><cites>FETCH-LOGICAL-c3924-fe47aa446cd430092be403acc90bfb453530944cfe5d9ca31c3bec37b87d3f543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16680108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15738039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwase, Akira</creatorcontrib><creatorcontrib>Ando, Hisao</creatorcontrib><creatorcontrib>Kuno, Keiko</creatorcontrib><creatorcontrib>Mizutani, Shigehiko</creatorcontrib><title>Use of Follicle-Stimulating Hormone Test to Predict Poor Response in In Vitro Fertilization</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>OBJECTIVE:Optimized ovarian stimulation protocols are required for the success of in vitro fertilization (IVF). The purpose of this study was to estimate whether the ovarian reserve test using exogenous follicle-stimulating hormone (FSH) could predict ovarian response in IVF.
METHODS:This was a prospective observational study of 110 patients who underwent their first IVF cycle. The FSH test was administered as 150 IU of urinary FSH daily from day 3 to day 6 of the menstrual cycle preceding the IVF cycle for evaluation of the plasma estradiol level. Outcomes of IVF, including ovarian response, were analyzed.
RESULTS:A negative correlation was observed between the duration of stimulation and the result of the FSH test (r = −.238, P = .014) and between the dose of FSH per retrieved mature oocyte (metaphase II oocyte) and the result of the FSH test (r = −.308, P < .001). In addition, our results showed that the result of the FSH test was significantly lower in poor responders defined by FSH of 400 IU/metaphase II oocyte or greater (207 ± 149 compared with 293 ± 174 pg/mL, P = .007).
CONCLUSION:The FSH test can be a useful tool for determining the conditions of individualized clinical management plans and optimizing stimulation protocols in IVF.
LEVEL OF EVIDENCE:II-2</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Clomiphene - administration & dosage</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Fertilization in Vitro</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Menotropins - administration & dosage</subject><subject>Oocytes</subject><subject>Ovarian Function Tests</subject><subject>Ovulation Induction</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Sensitivity and Specificity</subject><subject>Sperm Injections, Intracytoplasmic</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkGFL3TAUhsOYzKvbXxhhML-1O-lJm2bfRHZVEBSnY7APIU3TmS1t7pIW0V-_6L1wD4QD4XnzhoeQTwxKBlJ8AVaeXp-XkIfVFSIvK2SNLLF6Q1asFVjky59vyQqgkoVoOT8kRyn9eeEbie_IIasFtoByRX7dJ0vDQNfBe2e8Lb7Pbly8nt30m16EOIbJ0jubZjoHehNt78xMb0KI9NamTZhy2k30cqI_3BwDXds4O--ecz5M78nBoH2yH3b7mNyvv92dXRRX1-eXZ6dXhUFZ8WKwXGjNeWN6jgCy6iwH1MZI6IaO11gjSM7NYOteGo3MYGcNiq4VPQ41x2Nysn13E8O_Jf9VjS4Z672ebFiSagQXKCTL4NctaGJIKdpBbaIbdXxSDNSLWgVMZbVqr1a9qlVY5fDHXcvSjbbfR3cuM_B5B-hktB-inoxLe65pWmDQZo5vucfgZxvTX7882qgerPbzw2t1U9VQVAA1ZB9Q5IMc_wPbNpHF</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Iwase, Akira</creator><creator>Ando, Hisao</creator><creator>Kuno, Keiko</creator><creator>Mizutani, Shigehiko</creator><general>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200503</creationdate><title>Use of Follicle-Stimulating Hormone Test to Predict Poor Response in In Vitro Fertilization</title><author>Iwase, Akira ; Ando, Hisao ; Kuno, Keiko ; Mizutani, Shigehiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3924-fe47aa446cd430092be403acc90bfb453530944cfe5d9ca31c3bec37b87d3f543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Clomiphene - administration & dosage</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Fertility Agents, Female - administration & dosage</topic><topic>Fertilization in Vitro</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Menotropins - administration & dosage</topic><topic>Oocytes</topic><topic>Ovarian Function Tests</topic><topic>Ovulation Induction</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Sensitivity and Specificity</topic><topic>Sperm Injections, Intracytoplasmic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwase, Akira</creatorcontrib><creatorcontrib>Ando, Hisao</creatorcontrib><creatorcontrib>Kuno, Keiko</creatorcontrib><creatorcontrib>Mizutani, Shigehiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwase, Akira</au><au>Ando, Hisao</au><au>Kuno, Keiko</au><au>Mizutani, Shigehiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Follicle-Stimulating Hormone Test to Predict Poor Response in In Vitro Fertilization</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2005-03</date><risdate>2005</risdate><volume>105</volume><issue>3</issue><spage>645</spage><epage>652</epage><pages>645-652</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>OBJECTIVE:Optimized ovarian stimulation protocols are required for the success of in vitro fertilization (IVF). The purpose of this study was to estimate whether the ovarian reserve test using exogenous follicle-stimulating hormone (FSH) could predict ovarian response in IVF.
METHODS:This was a prospective observational study of 110 patients who underwent their first IVF cycle. The FSH test was administered as 150 IU of urinary FSH daily from day 3 to day 6 of the menstrual cycle preceding the IVF cycle for evaluation of the plasma estradiol level. Outcomes of IVF, including ovarian response, were analyzed.
RESULTS:A negative correlation was observed between the duration of stimulation and the result of the FSH test (r = −.238, P = .014) and between the dose of FSH per retrieved mature oocyte (metaphase II oocyte) and the result of the FSH test (r = −.308, P < .001). In addition, our results showed that the result of the FSH test was significantly lower in poor responders defined by FSH of 400 IU/metaphase II oocyte or greater (207 ± 149 compared with 293 ± 174 pg/mL, P = .007).
CONCLUSION:The FSH test can be a useful tool for determining the conditions of individualized clinical management plans and optimizing stimulation protocols in IVF.
LEVEL OF EVIDENCE:II-2</abstract><cop>New York, NY</cop><pub>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>15738039</pmid><doi>10.1097/01.AOG.0000152334.23169.32</doi><tpages>8</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 2005-03, Vol.105 (3), p.645-652 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Clomiphene - administration & dosage Estradiol - blood Female Fertility Agents, Female - administration & dosage Fertilization in Vitro Follicle Stimulating Hormone - blood Gynecology. Andrology. Obstetrics Humans Luteinizing Hormone - blood Medical sciences Menotropins - administration & dosage Oocytes Ovarian Function Tests Ovulation Induction Predictive Value of Tests Pregnancy Sensitivity and Specificity Sperm Injections, Intracytoplasmic |
| title | Use of Follicle-Stimulating Hormone Test to Predict Poor Response in In Vitro Fertilization |
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