Genetic Basis and Risk Factors for Infectious and Noninfectious Diseases in US Holsteins. I. Estimation of Genetic Parameters for Single Diseases and General Health
Health data collected from 1996 to 1999 from 177 herds in Minnesota and Wisconsin were analyzed to establish genetic basis for infectious and noninfectious diseases. Three types of health traits were targeted. First, available infectious conditions were used to identify animals that are superior in...
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| Veröffentlicht in: | Journal of dairy science 2005-03, Vol.88 (3), p.1199-1207 |
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| creator | Abdel-Azim, G.A. Freeman, A.E. Kehrli, M.E. Kelm, S.C. Burton, J.L. Kuck, A.L. Schnell, S. |
| description | Health data collected from 1996 to 1999 from 177 herds in Minnesota and Wisconsin were analyzed to establish genetic basis for infectious and noninfectious diseases. Three types of health traits were targeted. First, available infectious conditions were used to identify animals that are superior in their general immunity (including innate immunity) for infectious diseases. Generalized immunity may be thought of as a combination of immune responses to a variety of immune system challenges. Second, single infectious and noninfectious diseases were analyzed separately. Third, infectious reproductive diseases as one category of related conditions, and cystic ovary disease as one category of 3 related noninfectious ovary disorders were studied.
Data were analyzed using a threshold model that included herd, calving year, season of calving, and parity as cross-classified fixed factors; and sire and cow within sires as random effects. Days at risk and days in milk at the beginning of a record were included by fitting the days as continuous covariates in the model. A heritability value of 0.202±0.083 was estimated for generalized immunity. Heritability values of 0.141 and 0.161 were estimated for uterine infection and mastitis, respectively. Heritability of single noninfectious disorders ranged from 0.087 to 0.349. The amount of additive genetic variance recovered in the underlying scale of noninfectious disorders tended to zero when combining multiple conditions. The study supports combining infectious diseases into categories of interest but we do not recommend the same approach for noninfectious disorders. |
| doi_str_mv | 10.3168/jds.S0022-0302(05)72786-7 |
| format | Article |
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Data were analyzed using a threshold model that included herd, calving year, season of calving, and parity as cross-classified fixed factors; and sire and cow within sires as random effects. Days at risk and days in milk at the beginning of a record were included by fitting the days as continuous covariates in the model. A heritability value of 0.202±0.083 was estimated for generalized immunity. Heritability values of 0.141 and 0.161 were estimated for uterine infection and mastitis, respectively. Heritability of single noninfectious disorders ranged from 0.087 to 0.349. The amount of additive genetic variance recovered in the underlying scale of noninfectious disorders tended to zero when combining multiple conditions. The study supports combining infectious diseases into categories of interest but we do not recommend the same approach for noninfectious disorders.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.S0022-0302(05)72786-7</identifier><identifier>PMID: 15738253</identifier><identifier>CODEN: JDSCAE</identifier><language>eng</language><publisher>Savoy, IL: Elsevier Inc</publisher><subject>Abomasum ; animal diseases ; animal health ; Animal productions ; Animals ; Biological and medical sciences ; Cattle ; Cattle Diseases - epidemiology ; Cattle Diseases - genetics ; Cattle Diseases - immunology ; Communicable Diseases - epidemiology ; Communicable Diseases - genetics ; Communicable Diseases - veterinary ; disease prevalence ; disease resistance ; disease surveillance ; Female ; Food industries ; Fundamental and applied biological sciences. Psychology ; generalized immunity ; genetic evaluation ; Genetic Predisposition to Disease ; Health Status ; heritability ; Holstein ; immunity ; infectious diseases ; Lactation - genetics ; Lactation - physiology ; Lactation Disorders - epidemiology ; Lactation Disorders - genetics ; Lactation Disorders - veterinary ; Linear Models ; Male ; Mastitis, Bovine - epidemiology ; Mastitis, Bovine - genetics ; mathematical models ; Milk and cheese industries. Ice creams ; Minnesota - epidemiology ; Ovarian Cysts - epidemiology ; Ovarian Cysts - genetics ; Ovarian Cysts - veterinary ; ovarian diseases ; Parturient Paresis - epidemiology ; Parturient Paresis - genetics ; Pregnancy ; Quantitative Trait, Heritable ; Risk Factors ; Stomach Diseases - epidemiology ; Stomach Diseases - genetics ; Stomach Diseases - veterinary ; Terrestrial animal productions ; Vertebrates ; Wisconsin - epidemiology</subject><ispartof>Journal of dairy science, 2005-03, Vol.88 (3), p.1199-1207</ispartof><rights>2005 American Dairy Science Association</rights><rights>2005 INIST-CNRS</rights><rights>Copyright American Dairy Science Association Mar 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-7965b7499f55b608bdb70766cc19f607048c72d2b4f1ac6853f0c5144cafb7703</citedby><cites>FETCH-LOGICAL-c569t-7965b7499f55b608bdb70766cc19f607048c72d2b4f1ac6853f0c5144cafb7703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022030205727867$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16575289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15738253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdel-Azim, G.A.</creatorcontrib><creatorcontrib>Freeman, A.E.</creatorcontrib><creatorcontrib>Kehrli, M.E.</creatorcontrib><creatorcontrib>Kelm, S.C.</creatorcontrib><creatorcontrib>Burton, J.L.</creatorcontrib><creatorcontrib>Kuck, A.L.</creatorcontrib><creatorcontrib>Schnell, S.</creatorcontrib><title>Genetic Basis and Risk Factors for Infectious and Noninfectious Diseases in US Holsteins. I. Estimation of Genetic Parameters for Single Diseases and General Health</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>Health data collected from 1996 to 1999 from 177 herds in Minnesota and Wisconsin were analyzed to establish genetic basis for infectious and noninfectious diseases. Three types of health traits were targeted. First, available infectious conditions were used to identify animals that are superior in their general immunity (including innate immunity) for infectious diseases. Generalized immunity may be thought of as a combination of immune responses to a variety of immune system challenges. Second, single infectious and noninfectious diseases were analyzed separately. Third, infectious reproductive diseases as one category of related conditions, and cystic ovary disease as one category of 3 related noninfectious ovary disorders were studied.
Data were analyzed using a threshold model that included herd, calving year, season of calving, and parity as cross-classified fixed factors; and sire and cow within sires as random effects. Days at risk and days in milk at the beginning of a record were included by fitting the days as continuous covariates in the model. A heritability value of 0.202±0.083 was estimated for generalized immunity. Heritability values of 0.141 and 0.161 were estimated for uterine infection and mastitis, respectively. Heritability of single noninfectious disorders ranged from 0.087 to 0.349. The amount of additive genetic variance recovered in the underlying scale of noninfectious disorders tended to zero when combining multiple conditions. The study supports combining infectious diseases into categories of interest but we do not recommend the same approach for noninfectious disorders.</description><subject>Abomasum</subject><subject>animal diseases</subject><subject>animal health</subject><subject>Animal productions</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cattle Diseases - epidemiology</subject><subject>Cattle Diseases - genetics</subject><subject>Cattle Diseases - immunology</subject><subject>Communicable Diseases - epidemiology</subject><subject>Communicable Diseases - genetics</subject><subject>Communicable Diseases - veterinary</subject><subject>disease prevalence</subject><subject>disease resistance</subject><subject>disease surveillance</subject><subject>Female</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>generalized immunity</subject><subject>genetic evaluation</subject><subject>Genetic Predisposition to Disease</subject><subject>Health Status</subject><subject>heritability</subject><subject>Holstein</subject><subject>immunity</subject><subject>infectious diseases</subject><subject>Lactation - genetics</subject><subject>Lactation - physiology</subject><subject>Lactation Disorders - epidemiology</subject><subject>Lactation Disorders - genetics</subject><subject>Lactation Disorders - veterinary</subject><subject>Linear Models</subject><subject>Male</subject><subject>Mastitis, Bovine - epidemiology</subject><subject>Mastitis, Bovine - genetics</subject><subject>mathematical models</subject><subject>Milk and cheese industries. Ice creams</subject><subject>Minnesota - epidemiology</subject><subject>Ovarian Cysts - epidemiology</subject><subject>Ovarian Cysts - genetics</subject><subject>Ovarian Cysts - veterinary</subject><subject>ovarian diseases</subject><subject>Parturient Paresis - epidemiology</subject><subject>Parturient Paresis - genetics</subject><subject>Pregnancy</subject><subject>Quantitative Trait, Heritable</subject><subject>Risk Factors</subject><subject>Stomach Diseases - epidemiology</subject><subject>Stomach Diseases - genetics</subject><subject>Stomach Diseases - veterinary</subject><subject>Terrestrial animal productions</subject><subject>Vertebrates</subject><subject>Wisconsin - epidemiology</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1uEzEUhUcIREvhFcBUAsFigu0Z_y0htE2kChAha8vjsROHiaf4TkC8Dw-KpwkEsYGVZfu75-jcUxRPCZ5UhMtXmxYmC4wpLXGF6QvMXgoqJC_FneKUMMrKiih5tzj9jZwUDwA2-UooZveLE8JEJSmrTosfVy66IVj0xkAAZGKLPgb4jC6NHfoEyPcJzaN3dgj9bv__ro_h-PI2gDPgAIWIlgs06zsYXIgwQfMJuoAhbE0GI-o9-mX1wSSzdYM7yC9CXHXuKDR6jGgyHZo50w3rh8U9bzpwjw7nWbG8vPg0nZXX76_m09fXpWVcDaVQnDWiVsoz1nAsm7YRWHBuLVGeY4FraQVtaVN7YiyXrPLYMlLX1vhGCFydFc_3ujep_7JzMOhtAOu6zkSXs2ouakEUUf8E856rvO1R8fwvcNPvUswhNFFMYqZInSG1h2zqAZLz-ibltaXvmmA9Fq5z4fq2cD22qTHTt4VrkWcfHwx2zda1x8lDwxl4dgAMWNP5ZKINcOQ4E4zKPyKtw2r9LSSnYWu6LsuS0V5KXWlC1Ag-2YPe9NqsUhZbLigmObCSUiqZiemecLmrr8ElDTa4aF2bZe2g2z78R7KfSsrgvQ</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Abdel-Azim, G.A.</creator><creator>Freeman, A.E.</creator><creator>Kehrli, M.E.</creator><creator>Kelm, S.C.</creator><creator>Burton, J.L.</creator><creator>Kuck, A.L.</creator><creator>Schnell, S.</creator><general>Elsevier Inc</general><general>Am Dairy Sci Assoc</general><general>American Dairy Science Association</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>S0X</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Genetic Basis and Risk Factors for Infectious and Noninfectious Diseases in US Holsteins. 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Estimation of Genetic Parameters for Single Diseases and General Health</title><author>Abdel-Azim, G.A. ; Freeman, A.E. ; Kehrli, M.E. ; Kelm, S.C. ; Burton, J.L. ; Kuck, A.L. ; Schnell, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-7965b7499f55b608bdb70766cc19f607048c72d2b4f1ac6853f0c5144cafb7703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Abomasum</topic><topic>animal diseases</topic><topic>animal health</topic><topic>Animal productions</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cattle Diseases - epidemiology</topic><topic>Cattle Diseases - genetics</topic><topic>Cattle Diseases - immunology</topic><topic>Communicable Diseases - epidemiology</topic><topic>Communicable Diseases - genetics</topic><topic>Communicable Diseases - veterinary</topic><topic>disease prevalence</topic><topic>disease resistance</topic><topic>disease surveillance</topic><topic>Female</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>generalized immunity</topic><topic>genetic evaluation</topic><topic>Genetic Predisposition to Disease</topic><topic>Health Status</topic><topic>heritability</topic><topic>Holstein</topic><topic>immunity</topic><topic>infectious diseases</topic><topic>Lactation - genetics</topic><topic>Lactation - physiology</topic><topic>Lactation Disorders - epidemiology</topic><topic>Lactation Disorders - genetics</topic><topic>Lactation Disorders - veterinary</topic><topic>Linear Models</topic><topic>Male</topic><topic>Mastitis, Bovine - epidemiology</topic><topic>Mastitis, Bovine - genetics</topic><topic>mathematical models</topic><topic>Milk and cheese industries. Ice creams</topic><topic>Minnesota - epidemiology</topic><topic>Ovarian Cysts - epidemiology</topic><topic>Ovarian Cysts - genetics</topic><topic>Ovarian Cysts - veterinary</topic><topic>ovarian diseases</topic><topic>Parturient Paresis - epidemiology</topic><topic>Parturient Paresis - genetics</topic><topic>Pregnancy</topic><topic>Quantitative Trait, Heritable</topic><topic>Risk Factors</topic><topic>Stomach Diseases - epidemiology</topic><topic>Stomach Diseases - genetics</topic><topic>Stomach Diseases - veterinary</topic><topic>Terrestrial animal productions</topic><topic>Vertebrates</topic><topic>Wisconsin - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Azim, G.A.</creatorcontrib><creatorcontrib>Freeman, A.E.</creatorcontrib><creatorcontrib>Kehrli, M.E.</creatorcontrib><creatorcontrib>Kelm, S.C.</creatorcontrib><creatorcontrib>Burton, J.L.</creatorcontrib><creatorcontrib>Kuck, A.L.</creatorcontrib><creatorcontrib>Schnell, S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>SIRS Editorial</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel-Azim, G.A.</au><au>Freeman, A.E.</au><au>Kehrli, M.E.</au><au>Kelm, S.C.</au><au>Burton, J.L.</au><au>Kuck, A.L.</au><au>Schnell, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Basis and Risk Factors for Infectious and Noninfectious Diseases in US Holsteins. I. Estimation of Genetic Parameters for Single Diseases and General Health</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>88</volume><issue>3</issue><spage>1199</spage><epage>1207</epage><pages>1199-1207</pages><issn>0022-0302</issn><eissn>1525-3198</eissn><coden>JDSCAE</coden><abstract>Health data collected from 1996 to 1999 from 177 herds in Minnesota and Wisconsin were analyzed to establish genetic basis for infectious and noninfectious diseases. Three types of health traits were targeted. First, available infectious conditions were used to identify animals that are superior in their general immunity (including innate immunity) for infectious diseases. Generalized immunity may be thought of as a combination of immune responses to a variety of immune system challenges. Second, single infectious and noninfectious diseases were analyzed separately. Third, infectious reproductive diseases as one category of related conditions, and cystic ovary disease as one category of 3 related noninfectious ovary disorders were studied.
Data were analyzed using a threshold model that included herd, calving year, season of calving, and parity as cross-classified fixed factors; and sire and cow within sires as random effects. Days at risk and days in milk at the beginning of a record were included by fitting the days as continuous covariates in the model. A heritability value of 0.202±0.083 was estimated for generalized immunity. Heritability values of 0.141 and 0.161 were estimated for uterine infection and mastitis, respectively. Heritability of single noninfectious disorders ranged from 0.087 to 0.349. The amount of additive genetic variance recovered in the underlying scale of noninfectious disorders tended to zero when combining multiple conditions. The study supports combining infectious diseases into categories of interest but we do not recommend the same approach for noninfectious disorders.</abstract><cop>Savoy, IL</cop><pub>Elsevier Inc</pub><pmid>15738253</pmid><doi>10.3168/jds.S0022-0302(05)72786-7</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of dairy science, 2005-03, Vol.88 (3), p.1199-1207 |
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| subjects | Abomasum animal diseases animal health Animal productions Animals Biological and medical sciences Cattle Cattle Diseases - epidemiology Cattle Diseases - genetics Cattle Diseases - immunology Communicable Diseases - epidemiology Communicable Diseases - genetics Communicable Diseases - veterinary disease prevalence disease resistance disease surveillance Female Food industries Fundamental and applied biological sciences. Psychology generalized immunity genetic evaluation Genetic Predisposition to Disease Health Status heritability Holstein immunity infectious diseases Lactation - genetics Lactation - physiology Lactation Disorders - epidemiology Lactation Disorders - genetics Lactation Disorders - veterinary Linear Models Male Mastitis, Bovine - epidemiology Mastitis, Bovine - genetics mathematical models Milk and cheese industries. Ice creams Minnesota - epidemiology Ovarian Cysts - epidemiology Ovarian Cysts - genetics Ovarian Cysts - veterinary ovarian diseases Parturient Paresis - epidemiology Parturient Paresis - genetics Pregnancy Quantitative Trait, Heritable Risk Factors Stomach Diseases - epidemiology Stomach Diseases - genetics Stomach Diseases - veterinary Terrestrial animal productions Vertebrates Wisconsin - epidemiology |
| title | Genetic Basis and Risk Factors for Infectious and Noninfectious Diseases in US Holsteins. I. Estimation of Genetic Parameters for Single Diseases and General Health |
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