Expression of the hMLH1 and hMSH2 proteins in normal tissues: relationship to cancer predisposition in hereditary non-polyposis colon cancer
The majority of tumours in patients with hereditary non-polyposis colon cancer (HNPCC) occur in large intestine and endometrium; also, other tissues are at increased risk. We studied expression of hMLH1 and hMSH2 proteins in 148 normal samples of various tissues from non-HNPCC patients and in 14 nor...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2005-02, Vol.446 (2), p.112-119 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | PLEVOVA, Pavlina SEDLAKOVA, Eva ZAPLETALOVA, Jana KREPELOVA, Anna SKYPALOVA, Petra KOLAR, Zdenek |
| description | The majority of tumours in patients with hereditary non-polyposis colon cancer (HNPCC) occur in large intestine and endometrium; also, other tissues are at increased risk. We studied expression of hMLH1 and hMSH2 proteins in 148 normal samples of various tissues from non-HNPCC patients and in 14 normal colon tissues from HNPCC patients. Immunohistochemical technique was used. Intensity of nuclear staining, percentage of stained cells and H-scores were calculated. Tissues were divided into groups. Groups A, B and C included tissues with increased risk of cancer in HNPCC A) stomach, small and large bowel; (B) endometrium; (C) ovary, ureter, urinary bladder, kidney and liver. Group D tissues were without increased risk. Expression of the proteins was significantly higher in groups A, B and C compared with group D (P |
| doi_str_mv | 10.1007/s00428-004-1139-5 |
| format | Article |
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We studied expression of hMLH1 and hMSH2 proteins in 148 normal samples of various tissues from non-HNPCC patients and in 14 normal colon tissues from HNPCC patients. Immunohistochemical technique was used. Intensity of nuclear staining, percentage of stained cells and H-scores were calculated. Tissues were divided into groups. Groups A, B and C included tissues with increased risk of cancer in HNPCC A) stomach, small and large bowel; (B) endometrium; (C) ovary, ureter, urinary bladder, kidney and liver. Group D tissues were without increased risk. Expression of the proteins was significantly higher in groups A, B and C compared with group D (P<0.0001, P=0.0004 for hMSH2 in C versus D). The expression was highest in testis. In colons of HNPCC patients, expression of the mutated gene product was significantly lower than in non-HNPCC patients. In conclusion, hMLH1/hMSH2 protein expression is constitutively higher in certain cell types of certain tissues, including the majority of tissues that are at increased risk of cancer in HNPCC. However, association of strong hMLH1/hMSH2 expression with cancer risk is not strictly valid.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-004-1139-5</identifier><identifier>PMID: 15735976</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adaptor Proteins, Signal Transducing ; Base Pair Mismatch ; Biological and medical sciences ; Carrier Proteins ; Colon ; Colorectal cancer ; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics ; DNA Repair ; DNA-Binding Proteins - genetics ; Endometrium - chemistry ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression ; Genetic Predisposition to Disease ; Health risks ; Humans ; Immunohistochemistry ; Intestines - chemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Kidney - chemistry ; Liver - chemistry ; Male ; Medical research ; Medical sciences ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein ; Neoplasm Proteins - genetics ; Nuclear Proteins ; Ovary - chemistry ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Proteins ; Proto-Oncogene Proteins - genetics ; RNA, Messenger - analysis ; Stomach - chemistry ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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We studied expression of hMLH1 and hMSH2 proteins in 148 normal samples of various tissues from non-HNPCC patients and in 14 normal colon tissues from HNPCC patients. Immunohistochemical technique was used. Intensity of nuclear staining, percentage of stained cells and H-scores were calculated. Tissues were divided into groups. Groups A, B and C included tissues with increased risk of cancer in HNPCC A) stomach, small and large bowel; (B) endometrium; (C) ovary, ureter, urinary bladder, kidney and liver. Group D tissues were without increased risk. Expression of the proteins was significantly higher in groups A, B and C compared with group D (P<0.0001, P=0.0004 for hMSH2 in C versus D). The expression was highest in testis. In colons of HNPCC patients, expression of the mutated gene product was significantly lower than in non-HNPCC patients. In conclusion, hMLH1/hMSH2 protein expression is constitutively higher in certain cell types of certain tissues, including the majority of tissues that are at increased risk of cancer in HNPCC. However, association of strong hMLH1/hMSH2 expression with cancer risk is not strictly valid.</description><subject>Adaptor Proteins, Signal Transducing</subject><subject>Base Pair Mismatch</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins</subject><subject>Colon</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms, Hereditary Nonpolyposis - genetics</subject><subject>DNA Repair</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Endometrium - chemistry</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression</subject><subject>Genetic Predisposition to Disease</subject><subject>Health risks</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intestines - chemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidney - chemistry</subject><subject>Liver - chemistry</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>MutL Protein Homolog 1</subject><subject>MutS Homolog 2 Protein</subject><subject>Neoplasm Proteins - genetics</subject><subject>Nuclear Proteins</subject><subject>Ovary - chemistry</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>Stomach - chemistry</subject><subject>Stomach. Duodenum. 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We studied expression of hMLH1 and hMSH2 proteins in 148 normal samples of various tissues from non-HNPCC patients and in 14 normal colon tissues from HNPCC patients. Immunohistochemical technique was used. Intensity of nuclear staining, percentage of stained cells and H-scores were calculated. Tissues were divided into groups. Groups A, B and C included tissues with increased risk of cancer in HNPCC A) stomach, small and large bowel; (B) endometrium; (C) ovary, ureter, urinary bladder, kidney and liver. Group D tissues were without increased risk. Expression of the proteins was significantly higher in groups A, B and C compared with group D (P<0.0001, P=0.0004 for hMSH2 in C versus D). The expression was highest in testis. In colons of HNPCC patients, expression of the mutated gene product was significantly lower than in non-HNPCC patients. In conclusion, hMLH1/hMSH2 protein expression is constitutively higher in certain cell types of certain tissues, including the majority of tissues that are at increased risk of cancer in HNPCC. However, association of strong hMLH1/hMSH2 expression with cancer risk is not strictly valid.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15735976</pmid><doi>10.1007/s00428-004-1139-5</doi><tpages>8</tpages></addata></record> |
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| ispartof | Virchows Archiv : an international journal of pathology, 2005-02, Vol.446 (2), p.112-119 |
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| subjects | Adaptor Proteins, Signal Transducing Base Pair Mismatch Biological and medical sciences Carrier Proteins Colon Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA Repair DNA-Binding Proteins - genetics Endometrium - chemistry Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Genetic Predisposition to Disease Health risks Humans Immunohistochemistry Intestines - chemistry Investigative techniques, diagnostic techniques (general aspects) Kidney - chemistry Liver - chemistry Male Medical research Medical sciences MutL Protein Homolog 1 MutS Homolog 2 Protein Neoplasm Proteins - genetics Nuclear Proteins Ovary - chemistry Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proteins Proto-Oncogene Proteins - genetics RNA, Messenger - analysis Stomach - chemistry Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tissues Tumors Ureter - chemistry Urinary bladder Urinary Bladder - chemistry |
| title | Expression of the hMLH1 and hMSH2 proteins in normal tissues: relationship to cancer predisposition in hereditary non-polyposis colon cancer |
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