Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression

Platelet P-selectin plays important roles in inflammation and contributes to thrombosis and hemostasis. Although it has been reported that von Willebrand factor (VWF) affects P-selectin expression on endothelial cells, little information is available regarding regulation of platelet P-selectin expre...

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Veröffentlicht in:	Blood 2009-07, Vol.114 (2), p.425-436
Hauptverfasser:	Yang, Hong, Lang, Sean, Zhai, Zhimin, Li, Ling, Kahr, Walter H.A., Chen, Pingguo, Brkić, Jelena, Spring, Christopher M., Flick, Matthew J., Degen, Jay L., Freedman, John, Ni, Heyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biological and medical sciences Blood Platelets - metabolism Blood Platelets - ultrastructure Cell Membrane - metabolism Fibrinogen - genetics Fibrinogen - metabolism Hematologic and hematopoietic diseases Humans Integrin beta3 - metabolism Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure Intracellular Space - metabolism Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron P-Selectin - metabolism von Willebrand Factor - genetics von Willebrand Factor - metabolism
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