Structural Basis for the Highly Selective Inhibition of MMP-13

Inhibitors for matrix metalloproteinases (MMPs) are under investigation for the treatment of cancer, arthritis, and cardiovascular disease. Here, we report a class of highly selective MMP-13 inhibitors (pyrimidine dicarboxamides) that exhibit no detectable activity against other MMPs. The high-resol...

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Veröffentlicht in:	Chemistry & biology 2005-02, Vol.12 (2), p.181-189
Hauptverfasser:	Engel, Christian K., Pirard, Bernard, Schimanski, Sandra, Kirsch, Reinhard, Habermann, Jörg, Klingler, Otmar, Schlotte, Volkhard, Weithmann, Klaus Ulrich, Wendt, K. Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Collagenases - chemistry Crystallography, X-Ray Drug Design Matrix Metalloproteinase 13 Matrix Metalloproteinase Inhibitors Models, Molecular Molecular Sequence Data Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Protein Structure, Secondary Water
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