Bone marrow contribution to skeletal muscle: A physiological response to stress
Adult bone marrow-derived stem cells (BMDC) have been shown to contribute to numerous tissues after transplantation into a new host. However, whether the participation of these cells is part of the normal response to injury remains a matter of debate. Using parabiotically joined pairs of genetically...
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| Veröffentlicht in: | Developmental biology 2005-03, Vol.279 (2), p.336-344 |
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| creator | Palermo, Adam T. LaBarge, Mark A. Doyonnas, Regis Pomerantz, Jason Blau, Helen M. |
| description | Adult bone marrow-derived stem cells (BMDC) have been shown to contribute to numerous tissues after transplantation into a new host. However, whether the participation of these cells is part of the normal response to injury remains a matter of debate. Using parabiotically joined pairs of genetically labeled and wildtype mice, we show here that irradiation-induced damage of the target tissue, injection of bone marrow into the circulation, and immunological perturbation that are consequences of bone marrow transplantation are not necessary for bone marrow contribution to myofibers. Moreover, severe toxin-induced damage is not a prerequisite, as BMDC contribution to muscle is enhanced in response to increased muscle activity resulting from muscle overloading or forced exercise. Indeed, these two forms of muscle stress result in much more rapid contribution (within 1 month) than voluntary running (6 months). These results indicate that BMDC contribute to myofibers in response to physiologic stresses encountered by healthy organisms throughout life. |
| doi_str_mv | 10.1016/j.ydbio.2004.12.024 |
| format | Article |
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These results indicate that BMDC contribute to myofibers in response to physiologic stresses encountered by healthy organisms throughout life.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/j.ydbio.2004.12.024</identifier><identifier>PMID: 15733662</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult stem cells ; Animals ; Bone Marrow Transplantation ; Bone marrow-derived cells ; Damage ; Elapid Venoms - pharmacology ; Exercise ; Green Fluorescent Proteins - genetics ; Green Fluorescent Proteins - metabolism ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - physiology ; Irradiation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Activity ; Muscle ; Muscle Development - physiology ; Muscle, Skeletal - cytology ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - physiology ; Muscle, Skeletal - radiation effects ; Parabiosis ; Regeneration ; Running ; Stress, Physiological ; Transplantation</subject><ispartof>Developmental biology, 2005-03, Vol.279 (2), p.336-344</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-e07ea4504edca8384e6bb12cecd4db2bb8ee505f031e01e3999ff9e1d9d1cc933</citedby><cites>FETCH-LOGICAL-c357t-e07ea4504edca8384e6bb12cecd4db2bb8ee505f031e01e3999ff9e1d9d1cc933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ydbio.2004.12.024$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15733662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palermo, Adam T.</creatorcontrib><creatorcontrib>LaBarge, Mark A.</creatorcontrib><creatorcontrib>Doyonnas, Regis</creatorcontrib><creatorcontrib>Pomerantz, Jason</creatorcontrib><creatorcontrib>Blau, Helen M.</creatorcontrib><title>Bone marrow contribution to skeletal muscle: A physiological response to stress</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>Adult bone marrow-derived stem cells (BMDC) have been shown to contribute to numerous tissues after transplantation into a new host. However, whether the participation of these cells is part of the normal response to injury remains a matter of debate. Using parabiotically joined pairs of genetically labeled and wildtype mice, we show here that irradiation-induced damage of the target tissue, injection of bone marrow into the circulation, and immunological perturbation that are consequences of bone marrow transplantation are not necessary for bone marrow contribution to myofibers. Moreover, severe toxin-induced damage is not a prerequisite, as BMDC contribution to muscle is enhanced in response to increased muscle activity resulting from muscle overloading or forced exercise. Indeed, these two forms of muscle stress result in much more rapid contribution (within 1 month) than voluntary running (6 months). These results indicate that BMDC contribute to myofibers in response to physiologic stresses encountered by healthy organisms throughout life.</description><subject>Adult stem cells</subject><subject>Animals</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow-derived cells</subject><subject>Damage</subject><subject>Elapid Venoms - pharmacology</subject><subject>Exercise</subject><subject>Green Fluorescent Proteins - genetics</subject><subject>Green Fluorescent Proteins - metabolism</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Irradiation</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Motor Activity</subject><subject>Muscle</subject><subject>Muscle Development - physiology</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - physiology</subject><subject>Muscle, Skeletal - radiation effects</subject><subject>Parabiosis</subject><subject>Regeneration</subject><subject>Running</subject><subject>Stress, Physiological</subject><subject>Transplantation</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LxDAQxYMo7rr6FwjSk7fWSdOmreBBF79gYS8K3kKbTDVr29QkVfa_t_sB3jwNM7z3hvcj5JxCRIHyq1W0VpU2UQyQRDSOIE4OyJRCkYYpT94OyRSAxiHlwCfkxLkVALA8Z8dkQtOMMc7jKVnemQ6DtrTW_ATSdN7qavDadIE3gfvEBn3ZBO3gZIPXwW3Qf6ydNo1513K8W3S96RxuxX7c3Ck5qsvG4dl-zsjrw_3L_ClcLB-f57eLULI08yFChmWSQoJKljnLE-RVRWOJUiWqiqsqR0whrYFRBIqsKIq6LpCqQlEpC8Zm5HKX21vzNaDzotVOYtOUHZrBCZ4lGfCx5oywnVBa45zFWvRWj33XgoLYcBQrseUoNhwFjcXIcXRd7OOHqkX159mDGwU3OwGOJb81WuGkxk6i0halF8rofx_8ArLQhuo</recordid><startdate>20050315</startdate><enddate>20050315</enddate><creator>Palermo, Adam T.</creator><creator>LaBarge, Mark A.</creator><creator>Doyonnas, Regis</creator><creator>Pomerantz, Jason</creator><creator>Blau, Helen M.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050315</creationdate><title>Bone marrow contribution to skeletal muscle: A physiological response to stress</title><author>Palermo, Adam T. ; LaBarge, Mark A. ; Doyonnas, Regis ; Pomerantz, Jason ; Blau, Helen M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-e07ea4504edca8384e6bb12cecd4db2bb8ee505f031e01e3999ff9e1d9d1cc933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult stem cells</topic><topic>Animals</topic><topic>Bone Marrow Transplantation</topic><topic>Bone marrow-derived cells</topic><topic>Damage</topic><topic>Elapid Venoms - pharmacology</topic><topic>Exercise</topic><topic>Green Fluorescent Proteins - genetics</topic><topic>Green Fluorescent Proteins - metabolism</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Irradiation</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Motor Activity</topic><topic>Muscle</topic><topic>Muscle Development - physiology</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - physiology</topic><topic>Muscle, Skeletal - radiation effects</topic><topic>Parabiosis</topic><topic>Regeneration</topic><topic>Running</topic><topic>Stress, Physiological</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palermo, Adam T.</creatorcontrib><creatorcontrib>LaBarge, Mark A.</creatorcontrib><creatorcontrib>Doyonnas, Regis</creatorcontrib><creatorcontrib>Pomerantz, Jason</creatorcontrib><creatorcontrib>Blau, Helen M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palermo, Adam T.</au><au>LaBarge, Mark A.</au><au>Doyonnas, Regis</au><au>Pomerantz, Jason</au><au>Blau, Helen M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone marrow contribution to skeletal muscle: A physiological response to stress</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>2005-03-15</date><risdate>2005</risdate><volume>279</volume><issue>2</issue><spage>336</spage><epage>344</epage><pages>336-344</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><abstract>Adult bone marrow-derived stem cells (BMDC) have been shown to contribute to numerous tissues after transplantation into a new host. However, whether the participation of these cells is part of the normal response to injury remains a matter of debate. Using parabiotically joined pairs of genetically labeled and wildtype mice, we show here that irradiation-induced damage of the target tissue, injection of bone marrow into the circulation, and immunological perturbation that are consequences of bone marrow transplantation are not necessary for bone marrow contribution to myofibers. Moreover, severe toxin-induced damage is not a prerequisite, as BMDC contribution to muscle is enhanced in response to increased muscle activity resulting from muscle overloading or forced exercise. Indeed, these two forms of muscle stress result in much more rapid contribution (within 1 month) than voluntary running (6 months). 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| ispartof | Developmental biology, 2005-03, Vol.279 (2), p.336-344 |
| issn | 0012-1606 1095-564X |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult stem cells Animals Bone Marrow Transplantation Bone marrow-derived cells Damage Elapid Venoms - pharmacology Exercise Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Irradiation Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity Muscle Muscle Development - physiology Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Muscle, Skeletal - radiation effects Parabiosis Regeneration Running Stress, Physiological Transplantation |
| title | Bone marrow contribution to skeletal muscle: A physiological response to stress |
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