Leptin increases small intestinal response to cholecystokinin in leptin-deficient obese mice

Leptin receptors are present in the jejunum, ileum, and vagal neurons. Leptin increases duodenal secretion of cholecystokinin (CCK) and acts with CCK on vagal mechanoreceptors in the regulation of small intestinal motility. We have demonstrated that leptin-deficient (Lepob) obese mice have increased...

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Veröffentlicht in:	The Journal of surgical research 2005-03, Vol.124 (1), p.146-150
Hauptverfasser:	KIELY, James M, GRAEWIN, Shannon J, PITT, Henry A, SWARTZ-BASILE, Deborah A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Biological and medical sciences Cholecystokinin - pharmacology Female Gastrointestinal Motility - drug effects Gastrointestinal Motility - radiation effects General aspects In Vitro Techniques Injections, Intraperitoneal Intestine, Small - drug effects Intestine, Small - physiopathology Leptin - administration & dosage Medical sciences Metabolic diseases Mice Mice, Inbred C57BL Models, Animal Neurotransmitter Agents - pharmacology Obesity Obesity - physiopathology Peptide Hormones - administration & dosage
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