Chimeric Streptogramin-Tyrocidine Antibiotics that Overcome Streptogramin Resistance

Streptogramin antibiotics are comprised of two distinct chemical components: the type A polyketides and the type B cyclic depsipeptides. Clinical resistance to the type B streptogramins can occur via enzymatic degradation catalyzed by the lyase Vgb or by target modification through the action of Erm...

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Veröffentlicht in:	Chemistry & biology 2005-02, Vol.12 (2), p.229-235
Hauptverfasser:	Mukhtar, Tariq A., Koteva, Kalinka P., Wright, Gerard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacteria - drug effects Drug Resistance, Bacterial Methyltransferases - metabolism Microbial Sensitivity Tests Molecular Structure Stereoisomerism Streptogramins - chemistry Streptogramins - pharmacology Tyrocidine - chemistry Tyrocidine - pharmacology
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