Reticulocyte Counts and Their Relation to Hemoglobin Levels in Trauma Patients
BACKGROUND:Increased production of red blood cells (RBCs) should be reflected by increased reticulocyte counts (RC). With the introduction of modern fully automated measurements of RC, the recovery of hemoglobin (Hb) after blood loss might be assessed earlier. We investigated the temporal relation o...
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| Veröffentlicht in: | The Journal of trauma, injury, infection, and critical care injury, infection, and critical care, 2009-07, Vol.67 (1), p.121-124 |
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| container_title | The Journal of trauma, injury, infection, and critical care |
| container_volume | 67 |
| creator | Otterman, Marie-Louise Nijboer, Johanna M. van der Horst, Iwan C. C. van Meurs, Matijs ten Duis, Henk-Jan Nijsten, Maarten W. N. |
| description | BACKGROUND:Increased production of red blood cells (RBCs) should be reflected by increased reticulocyte counts (RC). With the introduction of modern fully automated measurements of RC, the recovery of hemoglobin (Hb) after blood loss might be assessed earlier. We investigated the temporal relation of Hb and RC in trauma patients.
METHODS:Over a 10-month period, all patients with trauma admitted to our University Medical Center were analyzed. Both Hb (reference valuesmales, 14.0–17.1 g/dL; females, 12.1–15.9 g/dL) and RC (8–26 promille) were determined with a Sysmex XE-2100 analyzer. RBC transfusions were administered in otherwise healthy patients below an Hb threshold of 6.9 g/dL. Hb and RC were analyzed for a maximum of 30 days posttrauma and related in multivariate analysis to age, sex, and comorbidity.
RESULTS:Two hundred and forty-one patients (age 52 years ± 21 years) were studied. In 28 patients (12%), one or more RBCs were administered with a mean of 2.2 RBCs (range, 1–4). Hb decreased to 10.9 g/dL ± 2.1 g/dL on day 3. RC rose from 16 ± 11 at admission to 38 promille ± 21 promille on day 13 (p < 0.0001). Nadir Hb values and maximum RC values were inversely related according to univariate analysis (Pearson R = −0.62, p < 0.001). In multivariate analysis, Hb remained the only significant determinant of RC (R = 0.64, p < 0.001).
CONCLUSIONS:Hb and RC are clearly related in trauma patients. Measuring RC may be helpful in predicting the rise of Hb after acute blood loss. |
| doi_str_mv | 10.1097/TA.0b013e318187a848 |
| format | Article |
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METHODS:Over a 10-month period, all patients with trauma admitted to our University Medical Center were analyzed. Both Hb (reference valuesmales, 14.0–17.1 g/dL; females, 12.1–15.9 g/dL) and RC (8–26 promille) were determined with a Sysmex XE-2100 analyzer. RBC transfusions were administered in otherwise healthy patients below an Hb threshold of 6.9 g/dL. Hb and RC were analyzed for a maximum of 30 days posttrauma and related in multivariate analysis to age, sex, and comorbidity.
RESULTS:Two hundred and forty-one patients (age 52 years ± 21 years) were studied. In 28 patients (12%), one or more RBCs were administered with a mean of 2.2 RBCs (range, 1–4). Hb decreased to 10.9 g/dL ± 2.1 g/dL on day 3. RC rose from 16 ± 11 at admission to 38 promille ± 21 promille on day 13 (p < 0.0001). Nadir Hb values and maximum RC values were inversely related according to univariate analysis (Pearson R = −0.62, p < 0.001). In multivariate analysis, Hb remained the only significant determinant of RC (R = 0.64, p < 0.001).
CONCLUSIONS:Hb and RC are clearly related in trauma patients. Measuring RC may be helpful in predicting the rise of Hb after acute blood loss.</description><identifier>ISSN: 0022-5282</identifier><identifier>EISSN: 1529-8809</identifier><identifier>DOI: 10.1097/TA.0b013e318187a848</identifier><identifier>PMID: 19590320</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Diseases of the osteoarticular system ; Female ; Follow-Up Studies ; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation ; Hemoglobins - metabolism ; Hemorrhage - blood ; Hemorrhage - diagnosis ; Hemorrhage - etiology ; Humans ; Injuries of the limb. Injuries of the spine ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Reticulocyte Count ; Reticulocytes - pathology ; Retrospective Studies ; ROC Curve ; Trauma Severity Indices ; Traumas. Diseases due to physical agents ; Wounds and Injuries - blood ; Wounds and Injuries - complications ; Wounds and Injuries - diagnosis</subject><ispartof>The Journal of trauma, injury, infection, and critical care, 2009-07, Vol.67 (1), p.121-124</ispartof><rights>2009 Lippincott Williams & Wilkins, Inc.</rights><rights>2009 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4481-28dd29dbb0d767026bdea41e500c85e6c9d85ba73c75c26c3d0b14429ec9ae5b3</citedby><cites>FETCH-LOGICAL-c4481-28dd29dbb0d767026bdea41e500c85e6c9d85ba73c75c26c3d0b14429ec9ae5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21736900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19590320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otterman, Marie-Louise</creatorcontrib><creatorcontrib>Nijboer, Johanna M.</creatorcontrib><creatorcontrib>van der Horst, Iwan C. C.</creatorcontrib><creatorcontrib>van Meurs, Matijs</creatorcontrib><creatorcontrib>ten Duis, Henk-Jan</creatorcontrib><creatorcontrib>Nijsten, Maarten W. N.</creatorcontrib><title>Reticulocyte Counts and Their Relation to Hemoglobin Levels in Trauma Patients</title><title>The Journal of trauma, injury, infection, and critical care</title><addtitle>J Trauma</addtitle><description>BACKGROUND:Increased production of red blood cells (RBCs) should be reflected by increased reticulocyte counts (RC). With the introduction of modern fully automated measurements of RC, the recovery of hemoglobin (Hb) after blood loss might be assessed earlier. We investigated the temporal relation of Hb and RC in trauma patients.
METHODS:Over a 10-month period, all patients with trauma admitted to our University Medical Center were analyzed. Both Hb (reference valuesmales, 14.0–17.1 g/dL; females, 12.1–15.9 g/dL) and RC (8–26 promille) were determined with a Sysmex XE-2100 analyzer. RBC transfusions were administered in otherwise healthy patients below an Hb threshold of 6.9 g/dL. Hb and RC were analyzed for a maximum of 30 days posttrauma and related in multivariate analysis to age, sex, and comorbidity.
RESULTS:Two hundred and forty-one patients (age 52 years ± 21 years) were studied. In 28 patients (12%), one or more RBCs were administered with a mean of 2.2 RBCs (range, 1–4). Hb decreased to 10.9 g/dL ± 2.1 g/dL on day 3. RC rose from 16 ± 11 at admission to 38 promille ± 21 promille on day 13 (p < 0.0001). Nadir Hb values and maximum RC values were inversely related according to univariate analysis (Pearson R = −0.62, p < 0.001). In multivariate analysis, Hb remained the only significant determinant of RC (R = 0.64, p < 0.001).
CONCLUSIONS:Hb and RC are clearly related in trauma patients. Measuring RC may be helpful in predicting the rise of Hb after acute blood loss.</description><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</subject><subject>Hemoglobins - metabolism</subject><subject>Hemorrhage - blood</subject><subject>Hemorrhage - diagnosis</subject><subject>Hemorrhage - etiology</subject><subject>Humans</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Reticulocyte Count</subject><subject>Reticulocytes - pathology</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Trauma Severity Indices</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Wounds and Injuries - blood</subject><subject>Wounds and Injuries - complications</subject><subject>Wounds and Injuries - diagnosis</subject><issn>0022-5282</issn><issn>1529-8809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0cuKFDEUBuAgitOOPoEgtdFdjSeXqiTLphkdoVEZynXI5bRdmqqMSZXDvL0ZulFwEZID338Wfwh5TeGKgpbvh-0VOKAcOVVUSauEekI2tGO6VQr0U7IBYKztmGIX5EUpPwBACK6ekwuqOw2cwYZ8vsVl9GtM_mHBZpfWeSmNnUMzHHHMzS1Gu4xpbpbU3OCUvsfkxrnZ42-MpamvIdt1ss3XqrBGX5JnBxsLvjrfl-Tbh-thd9Puv3z8tNvuWy-Eoi1TITAdnIMgewmsdwGtoNgBeNVh73VQnbOSe9l51nsewFEhmEavLXaOX5J3p713Of1asSxmGovHGO2MaS2ml6JXIKBCfoI-p1IyHsxdHiebHwwF81ijGbbm_xpr6s15_eomDP8y594qeHsGtngbD9nOfix_HaOS9xoenTi5-xQXzOVnXO8xmyPauBxN_RDouOQtA9Ag69TWwyj_A1JGiuk</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>Otterman, Marie-Louise</creator><creator>Nijboer, Johanna M.</creator><creator>van der Horst, Iwan C. C.</creator><creator>van Meurs, Matijs</creator><creator>ten Duis, Henk-Jan</creator><creator>Nijsten, Maarten W. N.</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200907</creationdate><title>Reticulocyte Counts and Their Relation to Hemoglobin Levels in Trauma Patients</title><author>Otterman, Marie-Louise ; Nijboer, Johanna M. ; van der Horst, Iwan C. C. ; van Meurs, Matijs ; ten Duis, Henk-Jan ; Nijsten, Maarten W. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4481-28dd29dbb0d767026bdea41e500c85e6c9d85ba73c75c26c3d0b14429ec9ae5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</topic><topic>Hemoglobins - metabolism</topic><topic>Hemorrhage - blood</topic><topic>Hemorrhage - diagnosis</topic><topic>Hemorrhage - etiology</topic><topic>Humans</topic><topic>Injuries of the limb. Injuries of the spine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Reticulocyte Count</topic><topic>Reticulocytes - pathology</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Trauma Severity Indices</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Wounds and Injuries - blood</topic><topic>Wounds and Injuries - complications</topic><topic>Wounds and Injuries - diagnosis</topic><toplevel>online_resources</toplevel><creatorcontrib>Otterman, Marie-Louise</creatorcontrib><creatorcontrib>Nijboer, Johanna M.</creatorcontrib><creatorcontrib>van der Horst, Iwan C. C.</creatorcontrib><creatorcontrib>van Meurs, Matijs</creatorcontrib><creatorcontrib>ten Duis, Henk-Jan</creatorcontrib><creatorcontrib>Nijsten, Maarten W. N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of trauma, injury, infection, and critical care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otterman, Marie-Louise</au><au>Nijboer, Johanna M.</au><au>van der Horst, Iwan C. C.</au><au>van Meurs, Matijs</au><au>ten Duis, Henk-Jan</au><au>Nijsten, Maarten W. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reticulocyte Counts and Their Relation to Hemoglobin Levels in Trauma Patients</atitle><jtitle>The Journal of trauma, injury, infection, and critical care</jtitle><addtitle>J Trauma</addtitle><date>2009-07</date><risdate>2009</risdate><volume>67</volume><issue>1</issue><spage>121</spage><epage>124</epage><pages>121-124</pages><issn>0022-5282</issn><eissn>1529-8809</eissn><abstract>BACKGROUND:Increased production of red blood cells (RBCs) should be reflected by increased reticulocyte counts (RC). With the introduction of modern fully automated measurements of RC, the recovery of hemoglobin (Hb) after blood loss might be assessed earlier. We investigated the temporal relation of Hb and RC in trauma patients.
METHODS:Over a 10-month period, all patients with trauma admitted to our University Medical Center were analyzed. Both Hb (reference valuesmales, 14.0–17.1 g/dL; females, 12.1–15.9 g/dL) and RC (8–26 promille) were determined with a Sysmex XE-2100 analyzer. RBC transfusions were administered in otherwise healthy patients below an Hb threshold of 6.9 g/dL. Hb and RC were analyzed for a maximum of 30 days posttrauma and related in multivariate analysis to age, sex, and comorbidity.
RESULTS:Two hundred and forty-one patients (age 52 years ± 21 years) were studied. In 28 patients (12%), one or more RBCs were administered with a mean of 2.2 RBCs (range, 1–4). Hb decreased to 10.9 g/dL ± 2.1 g/dL on day 3. RC rose from 16 ± 11 at admission to 38 promille ± 21 promille on day 13 (p < 0.0001). Nadir Hb values and maximum RC values were inversely related according to univariate analysis (Pearson R = −0.62, p < 0.001). In multivariate analysis, Hb remained the only significant determinant of RC (R = 0.64, p < 0.001).
CONCLUSIONS:Hb and RC are clearly related in trauma patients. Measuring RC may be helpful in predicting the rise of Hb after acute blood loss.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>19590320</pmid><doi>10.1097/TA.0b013e318187a848</doi><tpages>4</tpages></addata></record> |
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| subjects | Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Diseases of the osteoarticular system Female Follow-Up Studies General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Hemoglobins - metabolism Hemorrhage - blood Hemorrhage - diagnosis Hemorrhage - etiology Humans Injuries of the limb. Injuries of the spine Male Medical sciences Middle Aged Prognosis Reticulocyte Count Reticulocytes - pathology Retrospective Studies ROC Curve Trauma Severity Indices Traumas. Diseases due to physical agents Wounds and Injuries - blood Wounds and Injuries - complications Wounds and Injuries - diagnosis |
| title | Reticulocyte Counts and Their Relation to Hemoglobin Levels in Trauma Patients |
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