Thymidylate Synthase and Methylenetetrahydrofolate Reductase Gene Polymorphism in Normal Tissue As Predictors of Fluorouracil Sensitivity

To analyze thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with respect to fluorouracil (FU) sensitivity. The study included a retrospective analysis of 88 patients with metastatic colorectal cancer and a prospective trial with 51 patients also with measur...

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Veröffentlicht in:	Journal of clinical oncology 2005-03, Vol.23 (7), p.1365-1369
Hauptverfasser:	JAKOBSEN, Anders, NIELSEN, Jens Nederby, GYLDENKERNE, Niels, LINDEBERG, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Disease Progression Drug Screening Assays, Antitumor Female Fluorouracil - therapeutic use Humans Male Medical sciences Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Neoplasm Metastasis Polymorphism, Genetic Prospective Studies Retrospective Studies Thymidylate Synthase - genetics Tumors
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