Use of B7 costimulatory molecules as adjuvants in a prime-boost vaccination against Visna/Maedi ovine lentivirus

Abstract RNA transcripts of the B7 family molecule (CD80) are diminished in blood leukocytes from animals clinically affected with Visna/Maedi virus (VMV) infection. This work investigates whether the use of B7 genes enhances immune responses and protection in immunization-challenge approaches. Shee...

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Veröffentlicht in:	Vaccine 2009-07, Vol.27 (34), p.4591-4600
Hauptverfasser:	de Andrés, X, Reina, R, Ciriza, J, Crespo, H, Glaria, I, Ramírez, H, Grilló, M.J, Pérez, M.M, Andrésdóttir, V, Rosati, S, Suzan-Monti, M, Luján, L, Blacklaws, B.A, Harkiss, G.D, de Andrés, D, Amorena, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - genetics Adjuvants, Immunologic - pharmacology Allergy and Immunology Animals Antibodies, Viral - blood Applied microbiology B7 costimulatory molecules B7-1 Antigen - administration & dosage B7-1 Antigen - genetics B7-1 Antigen - pharmacology B7-2 Antigen - administration & dosage B7-2 Antigen - genetics B7-2 Antigen - pharmacology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Cloning Deoxyribonucleic acid DNA DNA vaccination Fundamental and applied biological sciences. Psychology Gene Products, env - administration & dosage Gene Products, env - genetics Gene Products, gag - administration & dosage Gene Products, gag - genetics Genes Genetic Vectors Immune system Immunization Immunization, Secondary - methods Infections Lymphocytes Male Microbiology Miscellaneous Ovine lentivirus Plasmids Pneumonia, Progressive Interstitial, of Sheep - prevention & control Sheep Small ruminant lentivirus Studies T-Lymphocytes, Cytotoxic - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - immunology Vaccinia virus - genetics Viral infections Viral Vaccines - immunology Virology Visna-maedi virus - genetics Visna-maedi virus - immunology
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