High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies

To support pharmacokinetic studies of ginsenosides, a novel method to quantitatively analyze ginsenoside Rg3 (Rg3), its prosapogenin ginsenoside Rh2 (Rh2) and aglycone 20(S)-protopanaxadiol (ppd) in rat plasma was developed and validated. The method was based on gradient separation of ginsenosides p...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-04, Vol.818 (2), p.167-173
Hauptverfasser:	XIE, Hai-Tang, WANG, Guang-Ji, WEI WANG, SUN, Jian-Guo, TUCKER, Ian, ZHAO, Xiao-Chen, XIE, Yuan-Yuan, HAO LI, JIANG, Xi-Ling, RUI WANG, XU, Mei-Juang
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Drug Stability Freezing Fundamental and applied biological sciences. Psychology General pharmacology Ginsenosides - blood Ginsenosides - isolation & purification Ginsenosides - pharmacokinetics Medical sciences Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Sapogenins - blood Sapogenins - isolation & purification Spectrometry, Mass, Electrospray Ionization Triterpenes - blood Triterpenes - isolation & purification
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