Earlier stages of colorectal cancer detected with immunochemical faecal occult blood tests
The aim of colorectal cancer screening is to improve prognosis by the detection of early cancer and precursor stages. We compared the stage distribution of asymptomatic colorectal cancer patients detected by a positive immunochemical or guaiac-based faecal occult blood test (FOBT) with symptomatic c...
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| Veröffentlicht in: | Netherlands journal of medicine 2009-05, Vol.67 (5), p.182-186 |
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| container_title | Netherlands journal of medicine |
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| creator | VAN ROSSUM, L. G. M VAN RIJN, A. F VAN MUNSTER, I. P JANSEN, J. B. M. J FOCKENS, P LAHEIJ, R. J. F DEKKER, E |
| description | The aim of colorectal cancer screening is to improve prognosis by the detection of early cancer and precursor stages. We compared the stage distribution of asymptomatic colorectal cancer patients detected by a positive immunochemical or guaiac-based faecal occult blood test (FOBT) with symptomatic colorectal cancer patients.
In a longitudinal cohort study tumour stages were assessed in 144 symptomatic (mean age 69.3 years, 56% male) and 41 asymptomatic colorectal cancer patients (mean age 64.9 years, 56% male) of which 11 were detected with guaiac FOBT s (G-FOBT, Hemoccult-II) and 30 with immunochemical FOBTs (I-FOBT, OCSensor). Stage distributions were used to calculate average stage specific predicted five-year survival rates and to analyse group differences with Wilcoxon log-rank test.
Colorectal cancer was detected in significantly earlier stages in symptomatic compared with asymptomatic patients patients (p |
| format | Article |
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In a longitudinal cohort study tumour stages were assessed in 144 symptomatic (mean age 69.3 years, 56% male) and 41 asymptomatic colorectal cancer patients (mean age 64.9 years, 56% male) of which 11 were detected with guaiac FOBT s (G-FOBT, Hemoccult-II) and 30 with immunochemical FOBTs (I-FOBT, OCSensor). Stage distributions were used to calculate average stage specific predicted five-year survival rates and to analyse group differences with Wilcoxon log-rank test.
Colorectal cancer was detected in significantly earlier stages in symptomatic compared with asymptomatic patients patients (p<0.0001). Average stage specific predicted five-year survival was 59.1% in symptomatic and 76.6% in asymptomatic patients. Compared with the symptomatic patients the stage distribution for colorectal cancer patients detected with Hemoccult-II was not significantly different(p=0.29), whereas colorectal cancer was detected at significantly earlier stages with the OCSensor (p<0.0001).Treatment could be confined to colonoscopy in 27% of the asymptomatic patients compared with 3% of the symptomatic patients (p<0.0001). Cancer distribution over the colon was comparable between symptomatic and asymptomatic patients (p=0.3).
Compared with symptomatic patients,patients detected by FOBT and especially immunochemical FOBT , presented significantly more often at earlier stages suggesting increased survival. Additionally treatment could more often be confined to colonoscopy.</description><identifier>ISSN: 0300-2977</identifier><identifier>EISSN: 1872-9061</identifier><identifier>PMID: 19581668</identifier><language>eng</language><publisher>Alphen aan den Rijn: Van zuiden</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Colonoscopy ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - therapy ; Early Detection of Cancer ; Feces ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Guaiac ; Humans ; Immunochemistry - methods ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Netherlands - epidemiology ; Randomized Controlled Trials as Topic ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Tumors</subject><ispartof>Netherlands journal of medicine, 2009-05, Vol.67 (5), p.182-186</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21464736$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19581668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN ROSSUM, L. G. M</creatorcontrib><creatorcontrib>VAN RIJN, A. F</creatorcontrib><creatorcontrib>VAN MUNSTER, I. P</creatorcontrib><creatorcontrib>JANSEN, J. B. M. J</creatorcontrib><creatorcontrib>FOCKENS, P</creatorcontrib><creatorcontrib>LAHEIJ, R. J. F</creatorcontrib><creatorcontrib>DEKKER, E</creatorcontrib><title>Earlier stages of colorectal cancer detected with immunochemical faecal occult blood tests</title><title>Netherlands journal of medicine</title><addtitle>Neth J Med</addtitle><description>The aim of colorectal cancer screening is to improve prognosis by the detection of early cancer and precursor stages. We compared the stage distribution of asymptomatic colorectal cancer patients detected by a positive immunochemical or guaiac-based faecal occult blood test (FOBT) with symptomatic colorectal cancer patients.
In a longitudinal cohort study tumour stages were assessed in 144 symptomatic (mean age 69.3 years, 56% male) and 41 asymptomatic colorectal cancer patients (mean age 64.9 years, 56% male) of which 11 were detected with guaiac FOBT s (G-FOBT, Hemoccult-II) and 30 with immunochemical FOBTs (I-FOBT, OCSensor). Stage distributions were used to calculate average stage specific predicted five-year survival rates and to analyse group differences with Wilcoxon log-rank test.
Colorectal cancer was detected in significantly earlier stages in symptomatic compared with asymptomatic patients patients (p<0.0001). Average stage specific predicted five-year survival was 59.1% in symptomatic and 76.6% in asymptomatic patients. Compared with the symptomatic patients the stage distribution for colorectal cancer patients detected with Hemoccult-II was not significantly different(p=0.29), whereas colorectal cancer was detected at significantly earlier stages with the OCSensor (p<0.0001).Treatment could be confined to colonoscopy in 27% of the asymptomatic patients compared with 3% of the symptomatic patients (p<0.0001). Cancer distribution over the colon was comparable between symptomatic and asymptomatic patients (p=0.3).
Compared with symptomatic patients,patients detected by FOBT and especially immunochemical FOBT , presented significantly more often at earlier stages suggesting increased survival. Additionally treatment could more often be confined to colonoscopy.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Colonoscopy</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Early Detection of Cancer</subject><subject>Feces</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Guaiac</subject><subject>Humans</subject><subject>Immunochemistry - methods</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Netherlands - epidemiology</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0300-2977</issn><issn>1872-9061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotlb_gmSju4E8Jq-llPoAwY1u3Ax52kimqZMM4r83YnV1uNyPc-85R2CJpSCdQhwfgyWiCHVECbEAZ6W8I4S4UOwULLBiEnMul-B1o6cU_QRL1W--wBygzSlP3ladoNU723bO1zZ7Bz9j3cI4jvMu260fo21M0P5HsrVzqtCknB2svtRyDk6CTsVfHHQFXm43z-v77vHp7mF989jtCVW1I4wZ0_4VzvTEOMNZsIIaR7WjPZZBYUQ0UVIio4KkRAbNLGVIcxcIEYauwPWv737KH3O7PIyxWJ-S3vk8l4GLnveqFw28PICzGb0b9lMc9fQ1_LXRgKsDoEvLFKYWP5Z_juBmJCin3zQ_akc</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>VAN ROSSUM, L. G. M</creator><creator>VAN RIJN, A. F</creator><creator>VAN MUNSTER, I. P</creator><creator>JANSEN, J. B. M. J</creator><creator>FOCKENS, P</creator><creator>LAHEIJ, R. J. F</creator><creator>DEKKER, E</creator><general>Van zuiden</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Earlier stages of colorectal cancer detected with immunochemical faecal occult blood tests</title><author>VAN ROSSUM, L. G. M ; VAN RIJN, A. F ; VAN MUNSTER, I. P ; JANSEN, J. B. M. J ; FOCKENS, P ; LAHEIJ, R. J. F ; DEKKER, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-255bb0617db42bdb65fc73bd3ad3418f9102a29880b9f8328fa5c350a6df227b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Colonoscopy</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Colorectal Neoplasms - therapy</topic><topic>Early Detection of Cancer</topic><topic>Feces</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Guaiac</topic><topic>Humans</topic><topic>Immunochemistry - methods</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Netherlands - epidemiology</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN ROSSUM, L. G. M</creatorcontrib><creatorcontrib>VAN RIJN, A. F</creatorcontrib><creatorcontrib>VAN MUNSTER, I. P</creatorcontrib><creatorcontrib>JANSEN, J. B. M. J</creatorcontrib><creatorcontrib>FOCKENS, P</creatorcontrib><creatorcontrib>LAHEIJ, R. J. F</creatorcontrib><creatorcontrib>DEKKER, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Netherlands journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN ROSSUM, L. G. M</au><au>VAN RIJN, A. F</au><au>VAN MUNSTER, I. P</au><au>JANSEN, J. B. M. J</au><au>FOCKENS, P</au><au>LAHEIJ, R. J. F</au><au>DEKKER, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Earlier stages of colorectal cancer detected with immunochemical faecal occult blood tests</atitle><jtitle>Netherlands journal of medicine</jtitle><addtitle>Neth J Med</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>67</volume><issue>5</issue><spage>182</spage><epage>186</epage><pages>182-186</pages><issn>0300-2977</issn><eissn>1872-9061</eissn><abstract>The aim of colorectal cancer screening is to improve prognosis by the detection of early cancer and precursor stages. We compared the stage distribution of asymptomatic colorectal cancer patients detected by a positive immunochemical or guaiac-based faecal occult blood test (FOBT) with symptomatic colorectal cancer patients.
In a longitudinal cohort study tumour stages were assessed in 144 symptomatic (mean age 69.3 years, 56% male) and 41 asymptomatic colorectal cancer patients (mean age 64.9 years, 56% male) of which 11 were detected with guaiac FOBT s (G-FOBT, Hemoccult-II) and 30 with immunochemical FOBTs (I-FOBT, OCSensor). Stage distributions were used to calculate average stage specific predicted five-year survival rates and to analyse group differences with Wilcoxon log-rank test.
Colorectal cancer was detected in significantly earlier stages in symptomatic compared with asymptomatic patients patients (p<0.0001). Average stage specific predicted five-year survival was 59.1% in symptomatic and 76.6% in asymptomatic patients. Compared with the symptomatic patients the stage distribution for colorectal cancer patients detected with Hemoccult-II was not significantly different(p=0.29), whereas colorectal cancer was detected at significantly earlier stages with the OCSensor (p<0.0001).Treatment could be confined to colonoscopy in 27% of the asymptomatic patients compared with 3% of the symptomatic patients (p<0.0001). Cancer distribution over the colon was comparable between symptomatic and asymptomatic patients (p=0.3).
Compared with symptomatic patients,patients detected by FOBT and especially immunochemical FOBT , presented significantly more often at earlier stages suggesting increased survival. Additionally treatment could more often be confined to colonoscopy.</abstract><cop>Alphen aan den Rijn</cop><pub>Van zuiden</pub><pmid>19581668</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Colonoscopy Colorectal Neoplasms - diagnosis Colorectal Neoplasms - epidemiology Colorectal Neoplasms - therapy Early Detection of Cancer Feces Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Guaiac Humans Immunochemistry - methods Longitudinal Studies Male Medical sciences Middle Aged Neoplasm Staging Netherlands - epidemiology Randomized Controlled Trials as Topic Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors |
| title | Earlier stages of colorectal cancer detected with immunochemical faecal occult blood tests |
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