Bicarbonate Plus Epinephrine Shortens the Onset and Prolongs the Duration of Sciatic Block Using Chloroprocaine Followed by Bupivacaine in Sprague-Dawley Rats
Chloroprocaine is a fast-acting local anesthetic, whereas bupivacaine is a long-acting one. They have been coadministered with limited success. The objective of this study was to determine the effect of additives on the efficacy of regional blockade using chloroprocaine followed by bupivacaine. Four...
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| Veröffentlicht in: | Regional anesthesia and pain medicine 2009-05, Vol.34 (3), p.196-200 |
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| creator | Yung, Elliot Lahoti, Tejas Jafari, Soheila Weinberg, Jonathan D. SchianodiCola, Joseph J. Yarmush, Joel M. Ray, Sidhartha D. |
| description | Chloroprocaine is a fast-acting local anesthetic, whereas bupivacaine is a long-acting one. They have been coadministered with limited success. The objective of this study was to determine the effect of additives on the efficacy of regional blockade using chloroprocaine followed by bupivacaine.
Four groups of Sprague-Dawley rats, 20 each, were administered chloroprocaine followed by bupivacaine to induce sciatic nerve blockade. Group 1 received chloroprocaine with isotonic sodium chloride solution followed by bupivacaine and was used as a control. Group 2 received chloroprocaine with isotonic sodium chloride solution and epinephrine followed by bupivacaine with epinephrine. Group 3 received chloroprocaine with sodium bicarbonate followed by bupivacaine, and group 4 received chloroprocaine with sodium bicarbonate and epinephrine followed by bupivacaine with epinephrine. The time to onset and duration of anesthesia were measured for all 4 groups.
The block using chloroprocaine followed by bupivacaine in group 1 had an onset of 2.5 mins (SD, 0.4 mins) and duration of 104 mins (SD, 16 mins). Adding epinephrine to both chloroprocaine and bupivacaine (group 2) did not significantly change the onset (2.8 mins [SD, 1.3 mins];
P = 0.35) or duration (110 mins [SD, 25 mins];
P = 0.23). With group 3, adding bicarbonate to chloroprocaine hastened the onset (1.2 mins [SD, 0.4 mins];
P < 0.0001) and shortened the duration (87 mins [SD, 13 mins];
P = 0.008). In group 4, adding bicarbonate and epinephrine to chloroprocaine and epinephrine to bupivacaine hastened the onset (1.4 mins [SD, 0.4 mins];
P < 0.0001) and increased the duration (130 mins [SD, 23 mins];
P < 0.0001).
Sodium bicarbonate plus epinephrine shortens the onset and prolongs the duration of a chloroprocaine-bupivacaine sciatic block in Sprague-Dawley rats. |
| doi_str_mv | 10.1097/AAP.0b013e31819a9528 |
| format | Article |
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Four groups of Sprague-Dawley rats, 20 each, were administered chloroprocaine followed by bupivacaine to induce sciatic nerve blockade. Group 1 received chloroprocaine with isotonic sodium chloride solution followed by bupivacaine and was used as a control. Group 2 received chloroprocaine with isotonic sodium chloride solution and epinephrine followed by bupivacaine with epinephrine. Group 3 received chloroprocaine with sodium bicarbonate followed by bupivacaine, and group 4 received chloroprocaine with sodium bicarbonate and epinephrine followed by bupivacaine with epinephrine. The time to onset and duration of anesthesia were measured for all 4 groups.
The block using chloroprocaine followed by bupivacaine in group 1 had an onset of 2.5 mins (SD, 0.4 mins) and duration of 104 mins (SD, 16 mins). Adding epinephrine to both chloroprocaine and bupivacaine (group 2) did not significantly change the onset (2.8 mins [SD, 1.3 mins];
P = 0.35) or duration (110 mins [SD, 25 mins];
P = 0.23). With group 3, adding bicarbonate to chloroprocaine hastened the onset (1.2 mins [SD, 0.4 mins];
P < 0.0001) and shortened the duration (87 mins [SD, 13 mins];
P = 0.008). In group 4, adding bicarbonate and epinephrine to chloroprocaine and epinephrine to bupivacaine hastened the onset (1.4 mins [SD, 0.4 mins];
P < 0.0001) and increased the duration (130 mins [SD, 23 mins];
P < 0.0001).
Sodium bicarbonate plus epinephrine shortens the onset and prolongs the duration of a chloroprocaine-bupivacaine sciatic block in Sprague-Dawley rats.</description><identifier>ISSN: 1098-7339</identifier><identifier>EISSN: 1532-8651</identifier><identifier>DOI: 10.1097/AAP.0b013e31819a9528</identifier><identifier>PMID: 19587615</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject><![CDATA[Adjuvants, Anesthesia - administration & dosage ; Anesthetics, Local - administration & dosage ; Animals ; Bupivacaine - administration & dosage ; Epinephrine - administration & dosage ; Hydrogen-Ion Concentration ; Injections ; Male ; Nerve Block ; Pain Measurement ; Pain Threshold - drug effects ; Procaine - administration & dosage ; Procaine - analogs & derivatives ; Rats ; Rats, Sprague-Dawley ; Regional anesthesia ; Sciatic Nerve - drug effects ; Sodium Bicarbonate - administration & dosage ; Time Factors]]></subject><ispartof>Regional anesthesia and pain medicine, 2009-05, Vol.34 (3), p.196-200</ispartof><rights>2009 American Society of Regional Anesthesia</rights><rights>Copyright Lippincott Williams & Wilkins May/Jun 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-26c822586a922d3b4426d9d80a28da48a7142f520563061c36c2e41c54679f8f3</citedby><cites>FETCH-LOGICAL-c479t-26c822586a922d3b4426d9d80a28da48a7142f520563061c36c2e41c54679f8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19587615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yung, Elliot</creatorcontrib><creatorcontrib>Lahoti, Tejas</creatorcontrib><creatorcontrib>Jafari, Soheila</creatorcontrib><creatorcontrib>Weinberg, Jonathan D.</creatorcontrib><creatorcontrib>SchianodiCola, Joseph J.</creatorcontrib><creatorcontrib>Yarmush, Joel M.</creatorcontrib><creatorcontrib>Ray, Sidhartha D.</creatorcontrib><title>Bicarbonate Plus Epinephrine Shortens the Onset and Prolongs the Duration of Sciatic Block Using Chloroprocaine Followed by Bupivacaine in Sprague-Dawley Rats</title><title>Regional anesthesia and pain medicine</title><addtitle>Reg Anesth Pain Med</addtitle><description>Chloroprocaine is a fast-acting local anesthetic, whereas bupivacaine is a long-acting one. They have been coadministered with limited success. The objective of this study was to determine the effect of additives on the efficacy of regional blockade using chloroprocaine followed by bupivacaine.
Four groups of Sprague-Dawley rats, 20 each, were administered chloroprocaine followed by bupivacaine to induce sciatic nerve blockade. Group 1 received chloroprocaine with isotonic sodium chloride solution followed by bupivacaine and was used as a control. Group 2 received chloroprocaine with isotonic sodium chloride solution and epinephrine followed by bupivacaine with epinephrine. Group 3 received chloroprocaine with sodium bicarbonate followed by bupivacaine, and group 4 received chloroprocaine with sodium bicarbonate and epinephrine followed by bupivacaine with epinephrine. The time to onset and duration of anesthesia were measured for all 4 groups.
The block using chloroprocaine followed by bupivacaine in group 1 had an onset of 2.5 mins (SD, 0.4 mins) and duration of 104 mins (SD, 16 mins). Adding epinephrine to both chloroprocaine and bupivacaine (group 2) did not significantly change the onset (2.8 mins [SD, 1.3 mins];
P = 0.35) or duration (110 mins [SD, 25 mins];
P = 0.23). With group 3, adding bicarbonate to chloroprocaine hastened the onset (1.2 mins [SD, 0.4 mins];
P < 0.0001) and shortened the duration (87 mins [SD, 13 mins];
P = 0.008). In group 4, adding bicarbonate and epinephrine to chloroprocaine and epinephrine to bupivacaine hastened the onset (1.4 mins [SD, 0.4 mins];
P < 0.0001) and increased the duration (130 mins [SD, 23 mins];
P < 0.0001).
Sodium bicarbonate plus epinephrine shortens the onset and prolongs the duration of a chloroprocaine-bupivacaine sciatic block in Sprague-Dawley rats.</description><subject>Adjuvants, Anesthesia - administration & dosage</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Animals</subject><subject>Bupivacaine - administration & dosage</subject><subject>Epinephrine - administration & dosage</subject><subject>Hydrogen-Ion Concentration</subject><subject>Injections</subject><subject>Male</subject><subject>Nerve Block</subject><subject>Pain Measurement</subject><subject>Pain Threshold - drug effects</subject><subject>Procaine - administration & dosage</subject><subject>Procaine - analogs & derivatives</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regional anesthesia</subject><subject>Sciatic Nerve - drug effects</subject><subject>Sodium Bicarbonate - administration & dosage</subject><subject>Time Factors</subject><issn>1098-7339</issn><issn>1532-8651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1r3DAQhk1padK0_6AU0UNvTvVhy9KlsLv5aCGQpduchSyPd5VqJVeyE_bP9LdGwQuFHHqZGYZn3hnmLYqPBJ8TLJuvi8X6HLeYMGBEEKllTcWr4pTUjJaC1-R1rrEUZcOYPCnepXSPMRZNxd8WJ0TWouGkPi3-Lq3RsQ1ej4DWbkrocrAehl3MEW12IY7gExp3gG59ghFp36F1DC747dy-mKIebfAo9GhjbK4NWrpgfqO7ZP0WrXYuxDDEYPSz5FVwLjxCh9oDWk6DfdBz33q0GaLeTlBe6EcHB_RTj-l98abXLsGHYz4r7q4uf62-lze31z9Wi5vSVI0cS8qNoLQWXEtKO9ZWFeWd7ATWVHS6ErohFe1rimvOMCeGcUOhIqaueCN70bOz4susm-_8M0Ea1d4mA85pD2FKiue_MUlJBj-_AO_DFH2-TWV1IjOFM1TNkIkhpQi9GqLd63hQBKtn81Q2T700L499OmpP7R66f0NHtzLwbQYgv-LBQlTJWPAGOhvBjKoL9v8bngA4Y6rS</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Yung, Elliot</creator><creator>Lahoti, Tejas</creator><creator>Jafari, Soheila</creator><creator>Weinberg, Jonathan D.</creator><creator>SchianodiCola, Joseph J.</creator><creator>Yarmush, Joel M.</creator><creator>Ray, Sidhartha D.</creator><general>Elsevier Inc</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Bicarbonate Plus Epinephrine Shortens the Onset and Prolongs the Duration of Sciatic Block Using Chloroprocaine Followed by Bupivacaine in Sprague-Dawley Rats</title><author>Yung, Elliot ; Lahoti, Tejas ; Jafari, Soheila ; Weinberg, Jonathan D. ; SchianodiCola, Joseph J. ; Yarmush, Joel M. ; Ray, Sidhartha D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-26c822586a922d3b4426d9d80a28da48a7142f520563061c36c2e41c54679f8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adjuvants, Anesthesia - administration & dosage</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Animals</topic><topic>Bupivacaine - administration & dosage</topic><topic>Epinephrine - administration & dosage</topic><topic>Hydrogen-Ion Concentration</topic><topic>Injections</topic><topic>Male</topic><topic>Nerve Block</topic><topic>Pain Measurement</topic><topic>Pain Threshold - drug effects</topic><topic>Procaine - administration & dosage</topic><topic>Procaine - analogs & derivatives</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Regional anesthesia</topic><topic>Sciatic Nerve - drug effects</topic><topic>Sodium Bicarbonate - administration & dosage</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yung, Elliot</creatorcontrib><creatorcontrib>Lahoti, Tejas</creatorcontrib><creatorcontrib>Jafari, Soheila</creatorcontrib><creatorcontrib>Weinberg, Jonathan D.</creatorcontrib><creatorcontrib>SchianodiCola, Joseph J.</creatorcontrib><creatorcontrib>Yarmush, Joel M.</creatorcontrib><creatorcontrib>Ray, Sidhartha D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Regional anesthesia and pain medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yung, Elliot</au><au>Lahoti, Tejas</au><au>Jafari, Soheila</au><au>Weinberg, Jonathan D.</au><au>SchianodiCola, Joseph J.</au><au>Yarmush, Joel M.</au><au>Ray, Sidhartha D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bicarbonate Plus Epinephrine Shortens the Onset and Prolongs the Duration of Sciatic Block Using Chloroprocaine Followed by Bupivacaine in Sprague-Dawley Rats</atitle><jtitle>Regional anesthesia and pain medicine</jtitle><addtitle>Reg Anesth Pain Med</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>34</volume><issue>3</issue><spage>196</spage><epage>200</epage><pages>196-200</pages><issn>1098-7339</issn><eissn>1532-8651</eissn><abstract>Chloroprocaine is a fast-acting local anesthetic, whereas bupivacaine is a long-acting one. They have been coadministered with limited success. The objective of this study was to determine the effect of additives on the efficacy of regional blockade using chloroprocaine followed by bupivacaine.
Four groups of Sprague-Dawley rats, 20 each, were administered chloroprocaine followed by bupivacaine to induce sciatic nerve blockade. Group 1 received chloroprocaine with isotonic sodium chloride solution followed by bupivacaine and was used as a control. Group 2 received chloroprocaine with isotonic sodium chloride solution and epinephrine followed by bupivacaine with epinephrine. Group 3 received chloroprocaine with sodium bicarbonate followed by bupivacaine, and group 4 received chloroprocaine with sodium bicarbonate and epinephrine followed by bupivacaine with epinephrine. The time to onset and duration of anesthesia were measured for all 4 groups.
The block using chloroprocaine followed by bupivacaine in group 1 had an onset of 2.5 mins (SD, 0.4 mins) and duration of 104 mins (SD, 16 mins). Adding epinephrine to both chloroprocaine and bupivacaine (group 2) did not significantly change the onset (2.8 mins [SD, 1.3 mins];
P = 0.35) or duration (110 mins [SD, 25 mins];
P = 0.23). With group 3, adding bicarbonate to chloroprocaine hastened the onset (1.2 mins [SD, 0.4 mins];
P < 0.0001) and shortened the duration (87 mins [SD, 13 mins];
P = 0.008). In group 4, adding bicarbonate and epinephrine to chloroprocaine and epinephrine to bupivacaine hastened the onset (1.4 mins [SD, 0.4 mins];
P < 0.0001) and increased the duration (130 mins [SD, 23 mins];
P < 0.0001).
Sodium bicarbonate plus epinephrine shortens the onset and prolongs the duration of a chloroprocaine-bupivacaine sciatic block in Sprague-Dawley rats.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>19587615</pmid><doi>10.1097/AAP.0b013e31819a9528</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1098-7339 |
| ispartof | Regional anesthesia and pain medicine, 2009-05, Vol.34 (3), p.196-200 |
| issn | 1098-7339 1532-8651 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67463921 |
| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Adjuvants, Anesthesia - administration & dosage Anesthetics, Local - administration & dosage Animals Bupivacaine - administration & dosage Epinephrine - administration & dosage Hydrogen-Ion Concentration Injections Male Nerve Block Pain Measurement Pain Threshold - drug effects Procaine - administration & dosage Procaine - analogs & derivatives Rats Rats, Sprague-Dawley Regional anesthesia Sciatic Nerve - drug effects Sodium Bicarbonate - administration & dosage Time Factors |
| title | Bicarbonate Plus Epinephrine Shortens the Onset and Prolongs the Duration of Sciatic Block Using Chloroprocaine Followed by Bupivacaine in Sprague-Dawley Rats |
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