Bacterial translocation (BT) in cirrhosis
Gut flora and bacterial translocation (BT) play an important role in the pathogenesis of the complications of cirrhosis. Research on the pathogenesis of BT and its clinical significance transcends established boundaries between microbiology, cell biology, intestinal pathophysiology, and immunology....
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| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 2005-03, Vol.41 (3), p.422-433 |
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| container_end_page | 433 |
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| container_issue | 3 |
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| container_title | Hepatology (Baltimore, Md.) |
| container_volume | 41 |
| creator | WIEST, Reiner GARCIA-TSAO, Guadalupe |
| description | Gut flora and bacterial translocation (BT) play an important role in the pathogenesis of the complications of cirrhosis. Research on the pathogenesis of BT and its clinical significance transcends established boundaries between microbiology, cell biology, intestinal pathophysiology, and immunology. This review delineates multiple mechanisms involved in the process of BT, with an emphasis on alterations in intestinal flora and mucosal barrier function, particularly immunological defense mechanisms. Current knowledge on the innate and adaptive immune response that allows a "friendly" communication between bacteria and host is summarized, and alterations occurring in cirrhosis that may facilitate BT are discussed. In addition, definition of a "pathological" BT is proposed together with an analysis of the anatomical site and route of BT. Finally, therapeutic approaches for the prevention of BT in experimental and human cirrhosis are reviewed. Future research in the field of BT in cirrhosis will allow the development of new therapeutic targets in the prevention of infections and other complications of cirrhosis. |
| doi_str_mv | 10.1002/hep.20632 |
| format | Article |
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Research on the pathogenesis of BT and its clinical significance transcends established boundaries between microbiology, cell biology, intestinal pathophysiology, and immunology. This review delineates multiple mechanisms involved in the process of BT, with an emphasis on alterations in intestinal flora and mucosal barrier function, particularly immunological defense mechanisms. Current knowledge on the innate and adaptive immune response that allows a "friendly" communication between bacteria and host is summarized, and alterations occurring in cirrhosis that may facilitate BT are discussed. In addition, definition of a "pathological" BT is proposed together with an analysis of the anatomical site and route of BT. Finally, therapeutic approaches for the prevention of BT in experimental and human cirrhosis are reviewed. Future research in the field of BT in cirrhosis will allow the development of new therapeutic targets in the prevention of infections and other complications of cirrhosis.</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.20632</identifier><identifier>PMID: 15723320</identifier><identifier>CODEN: HPTLD9</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley</publisher><subject>Bacterial Translocation ; Biological and medical sciences ; Decontamination ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunity, Innate ; Intestinal Mucosa - physiology ; Intestines - microbiology ; Liver Cirrhosis - immunology ; Liver Cirrhosis - microbiology ; Liver. Bile. Biliary tracts ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Nitric Oxide - physiology ; Other diseases. 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Research on the pathogenesis of BT and its clinical significance transcends established boundaries between microbiology, cell biology, intestinal pathophysiology, and immunology. This review delineates multiple mechanisms involved in the process of BT, with an emphasis on alterations in intestinal flora and mucosal barrier function, particularly immunological defense mechanisms. Current knowledge on the innate and adaptive immune response that allows a "friendly" communication between bacteria and host is summarized, and alterations occurring in cirrhosis that may facilitate BT are discussed. In addition, definition of a "pathological" BT is proposed together with an analysis of the anatomical site and route of BT. Finally, therapeutic approaches for the prevention of BT in experimental and human cirrhosis are reviewed. Future research in the field of BT in cirrhosis will allow the development of new therapeutic targets in the prevention of infections and other complications of cirrhosis.</description><subject>Bacterial Translocation</subject><subject>Biological and medical sciences</subject><subject>Decontamination</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Intestinal Mucosa - physiology</subject><subject>Intestines - microbiology</subject><subject>Liver Cirrhosis - immunology</subject><subject>Liver Cirrhosis - microbiology</subject><subject>Liver. Bile. Biliary tracts</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Nitric Oxide - physiology</subject><subject>Other diseases. Semiology</subject><subject>Probiotics - pharmacology</subject><subject>Vertebrates: digestive system</subject><issn>0270-9139</issn><issn>1527-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0D1PwzAUhWELgWgpDPwBlAVEh5RrO9eJR1rxJVViKbN14ziqUZoUOx349wSI1Oksj87wMnbNYcEBxMPW7RcClBQnbMpR5KmUCKdsCiKHVHOpJ-wixk8A0JkoztmEYy6kFDBl8yXZ3gVPTdIHamPTWep91yb3y8088W1ifQjbLvp4yc5qaqK7GnfGPp6fNqvXdP3-8rZ6XKdWctmnqkAUUpUWC5WDLUrBkaNG5zTprNLC8ayqiqwS0sqKSqSKU0mOAG1NDuWM3f3_7kP3dXCxNzsfrWsaal13iEblmZKo9QDn_9CGLsbgarMPfkfh23Awv13M0MX8dRnszXh6KHeuOsoxxABuR0DRUlMPLayPR6cUIhZc_gBdHmkd</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>WIEST, Reiner</creator><creator>GARCIA-TSAO, Guadalupe</creator><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Bacterial translocation (BT) in cirrhosis</title><author>WIEST, Reiner ; GARCIA-TSAO, Guadalupe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-6855236bc58670c8b2151595ee9a94d92e14dd84d23c3dab5ad1abaea05cfae53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Bacterial Translocation</topic><topic>Biological and medical sciences</topic><topic>Decontamination</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Intestinal Mucosa - physiology</topic><topic>Intestines - microbiology</topic><topic>Liver Cirrhosis - immunology</topic><topic>Liver Cirrhosis - microbiology</topic><topic>Liver. Bile. Biliary tracts</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Nitric Oxide - physiology</topic><topic>Other diseases. Semiology</topic><topic>Probiotics - pharmacology</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WIEST, Reiner</creatorcontrib><creatorcontrib>GARCIA-TSAO, Guadalupe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WIEST, Reiner</au><au>GARCIA-TSAO, Guadalupe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial translocation (BT) in cirrhosis</atitle><jtitle>Hepatology (Baltimore, Md.)</jtitle><addtitle>Hepatology</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>41</volume><issue>3</issue><spage>422</spage><epage>433</epage><pages>422-433</pages><issn>0270-9139</issn><eissn>1527-3350</eissn><coden>HPTLD9</coden><abstract>Gut flora and bacterial translocation (BT) play an important role in the pathogenesis of the complications of cirrhosis. Research on the pathogenesis of BT and its clinical significance transcends established boundaries between microbiology, cell biology, intestinal pathophysiology, and immunology. This review delineates multiple mechanisms involved in the process of BT, with an emphasis on alterations in intestinal flora and mucosal barrier function, particularly immunological defense mechanisms. Current knowledge on the innate and adaptive immune response that allows a "friendly" communication between bacteria and host is summarized, and alterations occurring in cirrhosis that may facilitate BT are discussed. In addition, definition of a "pathological" BT is proposed together with an analysis of the anatomical site and route of BT. Finally, therapeutic approaches for the prevention of BT in experimental and human cirrhosis are reviewed. Future research in the field of BT in cirrhosis will allow the development of new therapeutic targets in the prevention of infections and other complications of cirrhosis.</abstract><cop>Hoboken, NJ</cop><pub>Wiley</pub><pmid>15723320</pmid><doi>10.1002/hep.20632</doi><tpages>12</tpages></addata></record> |
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| issn | 0270-9139 1527-3350 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Bacterial Translocation Biological and medical sciences Decontamination Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Humans Immunity, Innate Intestinal Mucosa - physiology Intestines - microbiology Liver Cirrhosis - immunology Liver Cirrhosis - microbiology Liver. Bile. Biliary tracts Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Nitric Oxide - physiology Other diseases. Semiology Probiotics - pharmacology Vertebrates: digestive system |
| title | Bacterial translocation (BT) in cirrhosis |
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